Subjects (n = 23) performed three 3×8 seated leg press workouts on a flywheel ergometer to note the net caloric cost. This study's purpose was to examine net caloric cost as a function of total work on an inertial resistance exercise device offering more eccentric loading than conventional iso-tonic weight training equipment. High intraclass correlations for net caloric cost (0.89) and total work (0.94) result from data collected from 3 workouts. Average total work and net caloric cost values reveal a significant (r = 0.62, p < 0.05) correlation yielding the following equation: predicted net caloric cost = 33.2 + 0.006014331 (total work). Current study data also show favorable net caloric cost (1.24 kcal·kg−1·d−1), exercise efficiency (9.48 kcal × 10−3 per joule), and estimated mechanical loading (65 W min·kg−1 LBM·d−1) values. The results of the current study serve as baseline knowledge for exercise prescriptions pertaining to net caloric cost, exercise efficiency, and mechanical loading using this device.