Caliber-persistent artery (CPA) is a vascular malformation in which a branch of the labial artery penetrates into the submucosal tissue, maintaining its original caliber. It can be pulsatile and affect various parts of the body, but only a few rare cases appear in the oral cavity. This study reports on two cases of CPA on the lower lip. The first one is a 45-year-old female, presenting a whitish sessile papule with a clinical diagnosis of mucocele. The second one is a 68-year-old male presenting a soft sessile nodule with a clinical diagnosis of fibroma. In both cases, an excisional biopsy was performed, and significant bleeding was observed in the second. Microscopically, a thick-walled artery was present in the lamina propria. The final diagnosis of CPA was assigned, and the patients were lost during follow-up. Knowledge of this lesion by clinicians can avoid misdiagnosis and difficulties during biopsy. Caliber-persistent artery (CPA) is a vascular malformation in which a branch of the labial artery penetrates into the submucosal tissue, maintaining its original caliber. It can be pulsatile and affect various parts of the body, but only a few rare cases appear in the oral cavity. This study reports on two cases of CPA on the lower lip. The first one is a 45-year-old female, presenting a whitish sessile papule with a clinical diagnosis of mucocele. The second one is a 68-year-old male presenting a soft sessile nodule with a clinical diagnosis of fibroma. In both cases, an excisional biopsy was performed, and significant bleeding was observed in the second. Microscopically, a thick-walled artery was present in the lamina propria. The final diagnosis of CPA was assigned, and the patients were lost during follow-up. Knowledge of this lesion by clinicians can avoid misdiagnosis and difficulties during biopsy.