The current study was conducted to comprehend the variation of the growth pattern and the physiological status of Pangasius pangasius (Hamilton, 1822) reared in the pond from July 2021 to September 2021. A total of 90 brood individuals were collected from the Meghna River and studied for the present experiment. The overall growth pattern for P. pangasius was isometric (b = 3.00) in the Meghna River, while the male fish showed positive (b > 3.00) and the female showed a negative allometric growth pattern (b < 3.00). The Fulton's condition factor (KF) value was greater than 1, indicating a healthy population and a habitat with abundant food sources. Moreover, the KF value was found to be substantially related to total body mass. On the other hand, both sexes of P. pangasius had relative weight average values of more than 100, simply indicates the fish is naturally obese and has enough stored energy to maintain its physiology. The calculated form factors suggested an elongated body shape, which is typical of many riverine fishes. In addition, a small number of morphological traits varied significantly in the current study. Likewise, in the case of morphometric features, the principal component analysis showed a considerable degree of connectedness between the male and female individuals. The blood values showed no significant difference between the sexes. This might result from feeding fish the same kind of food and maintaining them in the same environment. However, the higher temperature might have caused slight blood abnormalities in both sexes. The current findings strongly support raising this fish in captivity and would offer useful information for fish farm owners, entrepreneurs, stakeholders, and other concerns in Bangladesh and surrounding nations.