Calcipotriol Research Articles

Hyperpigmentation due to calcipotriol (MC 903) plus heliotherapy in psoriatic patients. Three case reports.

Calcipotriol is a synthetic analogue of vitamin D, used in the treatment of psoriasis. Until now no specific sid-effects have been described after combined therapy with calcipotriol and UV. We describe 3 patients, who in the summer of 1993, after a combined treatment of calcipotriol and heliotherapy, developed hyperpigmentation in the site where the ointment had been applied. Hyperpigmentation healed spontaneously in less than 7 months. To the best of our knowledge there are no other reports of this side-effect due to calcipotriol. In our opinion the fact that the 3 patients presented the hyperpigmentation only on the treated lesions and that, in the past, they had not presented similar lesions after exposure to sunlight confirms the relationship between the hyperpigmentation and the combined treatment used.

Pitfalls in the Use of Dovonex

Pitfalls in the Use of Dovonex

Calcipotriol Solution Not as Effective as Betamethasone Valerate Solution for Scalp Psoriasis

Calcipotriol ointment has been shown to be nearly as effective as mid-potency topical corticosteroids in the treatment of body psoriasis. This

The anti-psoriatic 1.25-dihydroxyvitamin D, analogue calcipotriol (MC903) as well as the analogues EB1089 and KH1060 induce vitamin D receptor mediated transactivation: Different ligand sensitivity of receptor homo- and heterodimers

The anti-psoriatic 1.25-dihydroxyvitamin D, analogue calcipotriol (MC903) as well as the analogues EB1089 and KH1060 induce vitamin D receptor mediated transactivation: Different ligand sensitivity of receptor homo- and heterodimers

Collagen metabolism in normal human skin after application of calcipotriol: Stimulation of the aminoteminal propeptide of type III procollagen (PIINP), but potentiation of the corticosteroid-induced inhibition of PIIINP

Collagen metabolism in normal human skin after application of calcipotriol: Stimulation of the aminoteminal propeptide of type III procollagen (PIINP), but potentiation of the corticosteroid-induced inhibition of PIIINP

Calcipotriene Ointment: A New Topical Treatment for Psoriasis

Calcipotriene ointment 0.005% (Dovonex), marketed by Westwood Squibb Pharmaceuticals, has recently been approved by the United States Food and Drug Administration for the treatment of moderate plaque psoriasis. Calcipotriene, also called calcipotriol or MC 903, is a structural analogue of 1,25-dihydroxyvitamin D3 and is recognized with equal affinity by the 1,25-dihydroxyvitamin D3 receptor. However, calcipotriene's effects on calcium metabolism are 100 times less potent than those of vitamin D.1 In the mid-1980s it was found that 1,25-dihydroxyvitamin D3 inhibited the proliferation of fibroblasts in culture.2 Around the same time, a patient being treated with 1-alphahydroxyvitamin D3 for osteoporosis was reported to show dramatic improvement in her psoriasis.3 Soon after, several investigators reported the use of 1,25-dihydroxyvitamin D3 and a variety of analogues for the treatment of psoriasis. Several placebo-controlled, randomized, double-blind trials have found calcipotriene ointment to be effective, rapidly acting, and safe in the treatment of psoriasis.4,5,6 The drug is more …

Calcipotriol Useful for Congenital Ichthyoses

The congenital ichthyoses, although rare, tend to be disfiguring and disabling and are extremely difficult to treat. They are minimally responsive to alpha-hydroxy acids and moisturizers, and while they often respond to systemic retinoids, long-term use of retinoids is frought with serious side effects. Calcipotriol, a vitamin D3 analogue, inhibits epidermal proliferation and stimulates terminal differentiation; it has been used successfully for psoriasis. In the current …

Calcipotriol or clobetasol propionate occluded with a hydrocolloid dressing for treatment of nummular psoriasis.

Calcipotriol or clobetasol propionate occluded with a hydrocolloid dressing for treatment of nummular psoriasis.

Calcipotriol to be costly in psoriasis

Calcipotriol to be costly in psoriasis

Calcipotriol is more acceptable than dithranol in psoriasis

Calcipotriol is more acceptable than dithranol in psoriasis

P99 Calcipotriol potentiates the immunosuppressive effects of cyclosporin A in allogeneic reactions

P99 Calcipotriol potentiates the immunosuppressive effects of cyclosporin A in allogeneic reactions

Perhaps calcipotriol should be compared with dithranol in psoriasis

Perhaps calcipotriol should be compared with dithranol in psoriasis