Abstract
The congenital ichthyoses, although rare, tend to be disfiguring and disabling and are extremely difficult to treat. They are minimally responsive to alpha-hydroxy acids and moisturizers, and while they often respond to systemic retinoids, long-term use of retinoids is frought with serious side effects. Calcipotriol, a vitamin D3 analogue, inhibits epidermal proliferation and stimulates terminal differentiation; it has been used successfully for psoriasis. In the current …
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