The present state of the art to control the vehicular NOx emissions, uses costly VWTi catalysts with urea solution as reductant, which work at higher temperature >200 °C. The present investigation is therefore, devoted to design a detailed experimental work to synthesize low cost and improved low-temperature SCR activity of MnCo2O4 catalyst by comparing preparation methods, calcination strategies and using different reductants in a wide range of temperature 50–450 °C. The catalysts were prepared by co-precipitation (CP) and nanocasting (NC) methods. For selection of the best catalyst, its precursor was calcined in stagnant air, flowing air and under reactive calcination (RC) in CO-air mixture. The SCR of NO was studied using various reductants (H2, LPG and H2-LPG) in a tubular reactor under the following conditions: 200 mg catalyst, 500 ppm NO, 8% O2, 1000 ppm LPG, 1% H2, 0.1% NH3 in Ar with a total flow rate of 100 mL/min. The inlet and outlet of the reactor were analyzed with the help of NO/NO2/NOx analyzer and gas chromatography. The catalysts were characterized by XRD, XPS, BET, SEM-EDX and FTIR. The catalyst prepared by NC method followed by RC route (Cat-R) exhibited the best NO reduction of 98.7% below 200 °C with H2-LPG-SCR. The exceptionally high activity with high N2 selectivity and good stability of Cat-R under the laboratory conditions were found. Characterization signified that the catalyst which exhibited oxygen deficient, higher surface area and the higher rate of LPG oxidation consequently have better SCR activity.