Calcifying Epithelial Odontogenic Tumor Research Articles

Comprehensive management of Pindborg tumor in childhood: a case report

Relevance. The calcifying epithelial odontogenic tumor, also known as Pindborg tumor, is a locally aggressive neoplasm characterized by strands and medullary formations of flat and clear cells, often accompanied by spherical calcifications and amyloid-stained hyaline deposits. The Pindborg tumor is rare, representing less than 1% of odontogenic tumors, and typically manifests in individuals aged 20 to 60 years. However, there is a growing incidence of neoplasms of diverse origins in childhood. This article presents a clinical case detailing the comprehensive multi-stage treatment of a pediatric patient with a Pindborg tumor, facilitating complete rehabilitation before reaching adulthood.Clinical case description. This article presents a clinical case detailing the comprehensive management of a patient with a Pindborg tumor. The individual initially sought treatment at the Department of Pediatric Maxillofacial Surgery of A.I. Evdokimov Moscow State Medical and Dental University in 2020, undergoing complete combined treatment until November 2023. Full rehabilitation was successfully achieved by the time of adulthood through a series of four consecutive surgeries, including dental implantation, followed by prosthetics utilizing a non-removable orthopedic structure in the final stage.Conclusion. Initiating comprehensive rehabilitation at an early stage, including dental implantation before reaching adulthood, facilitates complete social adaptation in society and contributes to the patient's harmonious development.

Unusual Variant of Ameloblastoma with Calcifying Epithelial Odontogenic Tumor-like Areas in a Three-Year Old Child

The Calcifying Epithelial Odontogenic Tumor (CEOT) is a benign odontogenic tumor, comprising approximately 1% of all odontogenic tumors. It presents as a slow-growing tumor in posterior mandibular region. A three year-old female child from Multan, reported a swelling in right lower jaw progressively increasing in size eventually causing facial asymmetry. On intraoral examination, a protuberance was seen arising from posterior mandibular region and causing displacement of overlying teeth. The swelling was cystic on palpation and mildly tender. The patient underwent complete excision of lesion at a tertiary care center in her locality. The excision biopsy specimen was received at our lab which was intact and well preserved. A diagnosis of ameloblastoma with Calcifying epithelial odontogenic tumor-like areas was made. The patient was followed up after six months however no complaint of any recurrent swelling in the area of was recorded.

Hybrid Calcifying Epithelial Odontogenic Tumor and Ameloblastoma: A Report of an Extremely Rare Condition: Hybrid Calcifying Epithelial Odontogenic and Ameloblastoma Tumor

Calcifying epithelial odontogenic tumor (CEOT) and ameloblastoma are types of odontogenic tumors accounting for 1%, and 10% of all the odontogenic tumors. While sharing same odontogenic origin, these tumors are found to exhibit distinct clinicopathological features. In the present study, we present the third hybrid CEOT/Ameloblastoma tumor ever reported. The current CEOT/Amelobastoma is occurred after a previously operated CEOT in the same area. The patient was refered with distict clinical features of swelling and paresthesia. In the radiographic examination, a unilocular lesion with mixed internal structure and ambiguous periphery was seen which exhibited buccal and lingual cortical expansion, thining, and perforation as well as inferior alveolar canal perforation. The histopathology results suggested a CEOT/Ameloblastoma lesion. After the tumor removal, the patient was set up for further follow-ups and maxillofacial prosthesis.

Non-Calcifying/Langerhans Cell-Rich Calcifying Epithelial Odontogenic Tumour: A Critical Review of the Rare and Distinctive Entity.

The study aims to analyse the non-calcifying/Langerhans cell rich (NCLC) subtype of calcifying epithelial odontogenic tumour (CEOT). METHOD: The features of cases of the NCLC subtype of CEOT noted in the English literature by PubMed as well as 3 new cases were reviewed. Overall, twenty-one cases were noted. Many were women in the fourth to sixth decades (male-to-female ratio =1 to 2). Radiologically, the lesion is often unilocular with resorption of the affected teeth. Nineteen of the 21 cases occurred in the maxilla, especially the anterior portion. On pathological examination, epithelial cells are noted in non-calcifying amyloid-rich fibrous stroma. The main differential diagnosis is the amyloid subtype of central odontogenic fibroma. Immunohistochemical studies revealed the tumour epithelial cells were positive for cytokeratins and p63 and contained CD1a, S-100, and langerin-positive Langerhans cells. On a median follow-up of 2 years, one patient had a recurrence one year after curettage. The NCLC subtype of CEOT is unique as it contains significant numbers of Langerhans cells and has clinicopathological features distinctive from classic CEOT.

Calcifying epithelial odontogenic tumor- Review of literature

The Calcifying epithelial odontogenic tumour (CEOT), also known as Pindborg tumour, is a rare odontogenic neoplasm makes up 1% of all odontogenic tumours, characterized by its distinct histopathological features and challenging clinical management. CEOTs are benign epithelial odontogenic tumour that secretes an amyloid protein tending towards calcification, however they can be locally aggressive and have recurrence rates of 10% to 15%. This comprehensive review aims to provide a detailed overview of the CEOT, encompassing its epidemiology, clinical findings, radiographic features, histopathological characteristics and therapeutic strategies.

Calcifying Epithelial Odontogenic Tumor in a child: A Case Report

Calcifying epithelial odontogenic tumor (CEOT) or Pindborg tumor is a rare tumor which accounts for < 1% of all odontogenic tumors. It usually affects patients between the 3rd and 4th decades of life, however a wide age range from 8 to 92 years has been reported. This neoplasm may be associated with erupted or unerupted teeth. There are both intraosseous and extraosseous variants of CEOT and the posterior part of mandible is the most common location. We present an interesting case of CEOT involving the left side of the maxilla associated with unerupted canine and premolar in an 11‑year‑old girl.

PINDBORG TUMOR PRESENTING IN EARLY ADOLESCENT- A RARE CASE REPORT

As infrequent as it may be, a calcifying odontogenic tumor As infrequent as it may be, a calcifying odontogenic tumor is more commonly seen in the late decades of life. It is a locally aggressive lesion that might interfere function by virtue of its expansile growth through the cortices of the involved jaw. This is a case report of Pindborg tumor in 11 year old male in the right mandibular body region and a rundown on the various investigations done and the final treatment plan adopted. A review of literature on the lesion and justification for the chosen treatment modality is included.

CLINICAL PATHOLOGIC CONFERENCE CASE 1: A MULTILOCULAR RADIOLUCENCY OF THE RIGHT MANDIBLE

CLINICAL PATHOLOGIC CONFERENCE CASE 1: A MULTILOCULAR RADIOLUCENCY OF THE RIGHT MANDIBLE

PROSTHODONTIC MANAGEMENT OF RARE ODONTOGENIC TUMOR (PINDBORG TUMOR) WITH IMPLANT RETAINED MANDIBULAR OVERDENTURE

Pindborg tumour or calcifying epithelial odontogenic tumour (CEOT) is a rare, slow-growing benign tumour occurring most frequently in the posterior part of the mandibular arch. Management ranges from simple enucleation to a segmental resection of the mandible. The latter compromises the jaw foundation for any future prosthetic rehabilitation and warrants jaw reconstruction procedures to improve the retention and stability of the prosthesis. Using mini-implants in such compromised situations is a minimally invasive and cost-effective aid compared to conventional implants. The present case report documents the prosthetic rehabilitation of a patient who underwent mandibular resection for a Pindborg tumour using mini-implants.

Immunohistochemical study of insulin-like growth factor 1 in calcifying epithelial odontogenic tumor and ameloblastoma: experimental research.

The research sample consisted of 23 paraffin block from Oral Pathology Department, Faculty of Dentistry, Damascus University, including six biopsies of CEOT, two biopsies of the plexiform ameloblastoma and 14 biopsies of the follicular ameloblastoma. All specimen were prepared and immunostained with rabbit polyclonal antibody to IGF-1. Immunostaining was assessed according to German-semiquantitative scoring system, and then the results were aggregated and statistically analyzed using SPSS version 13.0 (Student's test for two independent samples, one-way analysis of variance, Kruskal-Wallis test and Mann-Whitney U-test), the significance level P value less than 0.05 was considered statistically significant. All CEOT and ameloblastoma samples were positive for IGF-1 staining, except one sample of ameloblastoma, which was negative. The results showed that there were no statistically significant differences between CEOT and ameloblastoma in the values of IGF-1 expression (P=0.993) and IGF-1 expression rates (P=0.874) and in the frequency of IGF-1 expression (P=0.761) and IGF-1 staining intensity score (P=0.731). IGF-1 plays an important role in the growth of odontogenic tumors and there are no differences in IGF-1 expression between CEOT and ameloblastoma.

Correlation of amyloid and ameloblast-associated proteins to odontogenic cysts and tumors: A cross-sectional study.

Odontogenic cysts and tumors often form hard and soft structures that resemble odontogenesis. It is well known that amyloid is produced in Pindborgtumors; however, it is still debatable whether it is also formed in other odontogenic tumors and cysts. This study aimed to detect the presence of amyloid in different odontogenic cysts and tumors in correlation to matrix proteins secreted during enamel formation; namely amelogenin and odontogenic ameloblast-associated protein. This study included formalin fixed paraffin embedded tissue blocks of 106 different types of odontogenic cysts and tumors. Congo red and thioflavin T were performed to confirm the presence of amyloid; immunohistochemistry was used to detect amelogenin and odontogenic ameloblast-associated protein. Amyloid was detected in pindborg tumors (conventional), adenomatoid odontogenic tumors, odontogenic fibroma (Amyloid variant), follicular solid and unicystic ameloblastomas, radicular cysts, dentigerous cysts, dentinogenic ghost cell odontogenic tumor, ameloblastic fibroma, calcifying odontogenic cyst, and primordial Odontogenic tumor. Amelogenin was detected in 95.3% of the cases, while odontogenic ameloblast-associated protein was detected in 93.4% of the cases. The association between odontogenic ameloblast-associated protein and amyloid was highly significant at p < 0.01. However, there was no significant relationship between amelogenin and amyloid p > 0.05. Although pindborg tumor is the bonafide example of amyloid deposition in odontogenic tumors, this study concluded that amyloid may be deposited in traces to massive amounts in various odontogenic cysts and tumors, and it is significantly linked to odontogenic ameloblast-associated protein but not amelogenin matrix protein, since all amyloid cases were odontogenic ameloblast associated protein positive.

56. Calcifying Epithelial Odontogenic Tumour – A Diagnostic Challenge

Calcifying epithelial odontogenic tumour (CEOT) or Pindborg’s tumour is a rare, benign, slow-growing dental neoplasm which is locally aggressive and can invade dentoalveolar bone with possible displacement of teeth and soft tissue. We present a case of CEOT, which was initially managed as cemento-osseous dysplasia (COD).

Clinical, Radiological features of Calcifying Epithelial Odontogenic Tumor: Report of two rare cases

The calcifying epithelial odontogenic tumor (CEOT) is a rare benign odontogenic tumor constitutes around 1% of all odontogenic tumours involving the jaw. The intraosseous and extraosseous variant constitutes about 95% and 5% of CEOT respectively. We have reported two CEOT cases. One is associated with an impacted left third molar in the maxilla of 39-year-old female patient, and the other with a sessile soft tissue gingival mass in the left molar region of a 30-year-old female patient. It also emphasizes the importance of advanced imaging and peculiar findings of computed tomography in diagnosing this rare tumour. The visualization of the internal structure of the lesion and the involvement of the neighbouring structures were considered very helpful for diagnosis and treatment planning. Early detection and treatment planning for such rare cases is required to prevent further complications.

Calcifying epithelial odontogenic tumor with maxillary sinus extension: Case report and therapeutic review

Calcifying epithelial odontogenic tumor (CEOT) is a rare benign neoplasm, with slow, localized, invasive, and asymptomatic growth. The involvement of the maxillary sinus by the neoplasm is rare, with its treatment controversial. The aim of this study was to describe the clinical, imaging, and therapeutic characteristics of a CEOT with maxillary sinus extension, as well as a literature review of therapeutic approaches and the prognoses obtained from cases of the same extension. In this case report, we report the case of a female patient, 49 years old, Caucasian, with mild asymmetry of the middle third of the face. Clinical and imaging examinations showed an intraosseous tumor in the posterior region of the left hemimaxillary, with imprecise limits and extension of 44×24×32 mm, compromising the alveolar process, maxillary posterior teeth, posterior hemipalatal region, left maxillary sinus, and orbital floor, associated with local expansion, tooth mobility, maxillary sinusopathy, and nasal obstruction. Calcifying epithelial odontogenic tumor diagnosis was obtained from incisional biopsy and histopathological examination. Surgical therapy of partial maxillectomy was performed from the Weber Ferguson Access with subsequent prosthetic rehabilitation. There were no postoperative complications. This case presented had satisfactory success with the therapy performed. The use of invasive therapies such as partial maxillectomies associated with transfacial approaches is an effective treatment for CEOT involving the maxillary sinus. Long-term follow-up is essential to avoid recurrences.

METACHRONOUS CALCIFYING EPITHELIAL ODONTOGENIC TUMOR WITH LONG-TERM FOLLOW-UP

This is a description of an extremely rare metachronous presentation of calcifying epithelial odontogenic tumor (CEOT) in a 52-year-old woman with a history of synchronous tumors 12 years earlier. The patient presented 2 peripheral CEOTs that appeared clinically as bilateral gingival swellings between the lower first premolar and canine. Both tumors recurred and an additional surgical removal was performed, with no recurrences observed after 3.5 years of follow-up. Eight years after the last consultation, the patient complained of an asymptomatic normochromic nodule of 2.5 cm in the lower posterior gingiva, causing saucerization of the alveolar cortical bone between the second premolar and first molar; the location ruled out the possibility of late recurrence. The diagnosis of CEOT was confirmed microscopically, with no additional tumor after 2 years. Long-term follow-up is recommended for patients with multiple CEOTs for better comprehension of this unique clinical presentation.

CALCIFYING EPITHELIAL ODONTOGENIC TUMOR IN THE POSTERIOR MAXILLA ASSOCIATED WITH A SUPERNUMERARY TOOTH: A CASE REPORT

The calcifying epithelial odontogenic tumor is a rare benign neoplasm responsible for approximately 1% of all odontogenic tumors. Cases involving the maxilla are uncommon, even more so when it also involves supernumerary tooth. We describe the case of a 33-year-old female patient exhibiting swelling in the right maxilla. On radiographic examination, an isodense area was found associated with an impacted supernumerary tooth. Cone beam computed tomography also revealed expansive growth of the lesion in the maxillary sinus that caused the displacement of the first and second upper right premolars. The patient underwent an incisional biopsy, and the histopathologic diagnosis was a calcifying epithelial odontogenic tumor. After the first diagnosis, an excisional biopsy was done that confirmed the diagnosis. The treatment of choice was surgical removal of the lesion and associated dental elements. The patient has been followed up for 11 months and shows no signs of recurrence.

PERIPHERAL CLEAR CELL VARIANT OF CALCIFYING EPITHELIAL ODONTOGENIC TUMOR: CASE REPORT AND IMMUNOHISTOCHEMICAL ANALYSIS

Calcifying epithelial odontogenic tumor (CEOT) is an uncommon lesion that accounts for less than 1% of all odontogenic tumors. Cases of the peripheral clear cell variant are rarely reported. Herein we report a case of peripheral clear cell variant of CEOT occurring in a 24-year-old female patient who presented with a superficially ulcerated nodular lesion in the gingiva between the left inferior canine and first lower premolar teeth. The periapical radiograph showed no alterations. Microscopically, the lesion showed proliferation of polyhedral cells, mostly with clear cell cytoplasm, surrounded by amyloid material and areas of calcification. The amyloid material was positive for Congo red staining. Immunohistochemistry showed focal positive reactions to cytokeratin 7, 14, and 19. The clear cells were periodic acid-Schiff stain-positive diastase-resistant. A diagnosis of peripheral clear cell variant of the CEOT was made, and the patient was considered treated and is currently under follow-up.

CALCIFYING EPITHELIAL ODONTOGENIC TUMOR: REPORT OF A CASE AND REVIEW OF LITERATURE

The calcifying epithelial odontogenic tumour (CEOT), also known as Pindborg's tumour. It is a rare benign neoplasm of locally aggressive behaviour originating from stratum intermedium. CEOT accounts for approximately 0.4 – 3 % of all the odontogenic tumours' most frequent location is mandibular premolar and molar area; less frequently, in the maxilla, typically formed in the fourth to fth decades. It usually presents as a slow growing, rm, painless mass and it shares many features with ameloblastoma. Due to a fairly common tendency of recurrence, estimated to be approximately 14 %, the preferred choice of treatment is radical surgical procedure and postoperative follow up . This case report presents the clinical, radiological ndings, histopathology, and surgical treatment of the patient with pindborg tumour were presented. The report is supplemented by a review of literature.

Combined Adenomatoid Odontogenic Tumor and Calcifying Epithelial Odontogenic Tumor: A report of three cases and a review of the literature

Odontogenic tumors present considerable histopathologic diversity. Lesions with combined features of more than one entity present a diagnostic challenge. One such lesion described in the literature is the combined lesion of adenomatoid odontogenic tumor (AOT) and calcifying epithelial odontogenic tumor (CEOT). Due to its rarity, there is limited data regarding its histopathologic features and clinical behaviors. Here, we present three cases of odontogenic tumors with features of both AOT and CEOT. AOT usually occurs in female teenagers with predilection for the anterior maxilla and is often associated with an impacted tooth. In contrast, CEOT is often found in patients at the age of 30-50 years and has a predilection for the posterior mandible. CEOT is also often associated with impacted teeth. We searched the cases of Oral Pathology Lab at NYPQ from 1986-2021 and identified 63 AOTs, 24 CEOTs, and 3 AOT/CEOTs. All 3 AOT/CEOT cases were from females between ages 13-19 and were described as cystic lesions associated with impacted teeth in the anterior maxilla. Radiographic findings were described as mixed or radiolucent. The demographics and sites of our AOT/CEOT cases resemble those of AOT as opposed to CEOT. The histology revealed odontogenic epithelial tumors composed of polygonal and spindle-shaped cells arranged in whorls, rosettes, and gland-like structures. Admixed throughout the tumors were sheets and strands of polyhedral epithelial cells with variably shaped nuclei set in abundant eosinophilic cytoplasm. Amorphous eosinophilic material and concentric calcifications were noted throughout. A Congo Red stain was positive in the one case it was performed. While both collision and hybrid theories have been suggested etiologies for AOT/CEOT, the admixture of the two components supports the latter. The similarity of our cases to the demographics of AOT, and the difference in sites and demographics of AOT and CEOT speaks against the collision theory.

Calcifying Epithelial Odontogenic Tumor: A Case Series Spanning 25 years

The calcifying epithelial odontogenic tumor (CEOT), also known as the Pindborg tumor, is a rare benign neoplasm which makes up less than 1% of all odontogenic tumors. The purpose of this study is to describe a series of cases of CEOT spanning 25 years. METHODS: With IRB approval, all cases diagnosed as CEOT between 1994 and 2019 were retrieved from the archives of the UF Oral Pathology Biopsy Service. RESULTS: A total of 22 cases were included in the study. Patient age ranged from 8 years to 70 years with an average of 40 years. Females were affected slightly more often (55%, n=12) than males (45%, n=10). The mandible was a more common location (55%, n=12) than the maxilla (45%, n=10) by a small margin. A clinical impression was provided by the clinician in 17 cases, of which the most common (53%, n=9) was that of a cystic lesion (including dentigerous/follicular cyst, periapical/inflammatory cyst, lateral periodontal cyst and odontogenic keratocyst). Radiographs were available for 7 cases and the most common radiographic presentation was a unilocular mixed radiolucent/radiopaque lesion (43%, n=3). Lesion du- ration was provided in 9 cases and the range was from 3 months to 10 years. The histologic diagnosis of CEOT was made for all cases. One case was believed to represent a recurrent tumor. Also included were the variants "incip- ient CEOT" (8%, n=2) and "peripheral CEOT" (8%, n=2). One case exhibited features of adenomatoid odontogenic tumor in addition to CEOT. Congo red staining for amyloid was performed in 14 cases, all of which were positive. CONCLUSION: CEOT is an uncommon tumor with a variable presentation and affects patients across a wide age range. Although most cases are intraosseous, the peripheral counterpart is occasionally encountered.