Abstract
Calcifying epithelial odontogenic tumor (CEOT) is an uncommon lesion that accounts for less than 1% of all odontogenic tumors. Cases of the peripheral clear cell variant are rarely reported. Herein we report a case of peripheral clear cell variant of CEOT occurring in a 24-year-old female patient who presented with a superficially ulcerated nodular lesion in the gingiva between the left inferior canine and first lower premolar teeth. The periapical radiograph showed no alterations. Microscopically, the lesion showed proliferation of polyhedral cells, mostly with clear cell cytoplasm, surrounded by amyloid material and areas of calcification. The amyloid material was positive for Congo red staining. Immunohistochemistry showed focal positive reactions to cytokeratin 7, 14, and 19. The clear cells were periodic acid-Schiff stain-positive diastase-resistant. A diagnosis of peripheral clear cell variant of the CEOT was made, and the patient was considered treated and is currently under follow-up.
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