Cadmium Complexes Research Articles

Construction of crystalline cadmium complex based on 1,4,5,8‐naphthalene diimide derivative and photocatalytic degradation about organic dyes

AbstractThe complex [Cd(PDNDI)]·DMF (Cd‐PDNDI) (H2PDNDI = N‐(4‐pyridine)‐4,5‐dicarboxy‐1,8‐naphthalene dicarboxyimide) was synthesized by the reaction of N,N′‐di(4‐pyridyl)‐1,4,5,8‐naphthalene diimide (DPNDI) and Cd(NO3)2·4H2O. It was characterized by elemental analysis, infrared spectroscopy, ultraviolet–visible (UV‐vis) spectroscopy, powder X‐ray diffraction (PXRD), single crystal X‐ray diffraction, and thermogravimetric analysis. Structural analysis shows that the Cd‐PDNDI has a self‐assembled 3D network structure with the rtl type topology. It is worth mentioning that the composition of the ligand is different from the initial raw material used in this molecular structure. This may be because the ligand undergoes an in situ hydrolysis reaction in the reaction system and becomes an NDI carboxylic acid derivative, which continues to join coordination reaction with the metal ion. In addition, the Cd‐PDNDI has an excellent photocatalytic effect on malachite green (MG) among the six dyes, which shows that the Cd‐PDNDI could be used as a photocatalytic material for the degradation of dyes.

Antimicrobial and antioxidant studies of Schiff base, 2-(2-hydroxy-2-methyl-1-phenylpropylidene) hydrazine carbothioamide and its mixed ligand cd (II) complexes

New mononuclear mixed ligand Cadmium(II) complexes of the type [Cd(L)(diimine)] (1,2) [where L = 2-(2-hydroxy-2-methyl-1-phenylpropylidene)hydrazinecarbothioamide; diimine = 2,2’-bipyridine (1), 1,10-phenanthroline (2)] have been synthesized and characterized by spectroscopic techniques such as FT-IR, UV-Visible, and1H and 13CNMR Spectroscopy. From the investigations of spectral data, it is evident that the heterocyclic bases (2,2’-bipyridine and 1,10-Phenanthroline) act as neutral bidentate ligand coordinating to the metal ion through two nitrogen donor atoms addition to azomethane nitrogen, thiolate Sulphur, and hydroxyl oxygen in the Schiff base ligand. The synthesized Schiff base metal chelates have been screened for their anti-microbial activities using the agar well diffusion method against different selected types of bacteria and fungi in addition to antioxidant activity. The prepared Schiff base ligand and its metal complexes exhibited good antimicrobial and antioxidant activities. The antibacterial and antifungal efficacy of Complex-1 was higher than that of all the prepared compounds. In the case of antioxidant activity, Complex-2 has stronger scavenging activity among them. Keywords: Cd (II) metal complexes, 2,2’-Bipyridine, 1,10-Phenanthroline, Antimicrobial activities.

Complexation of Amino Acids with Cadmium and Their Application for Cadmium-Contaminated Soil Remediation

The interaction of amino acids with toxic heavy metals influences their immobilization and bioavailability in soils. However, the complexation ability of amino acids with Cd has not been well studied. The complexes of amino acids and cadmium were investigated by density functional theory (DFT) calculations and Fourier transform infrared spectrometry (FTIR) analyses. The complex structures were found to be [COc, COc] for fatty amino-cadmium and PheCd2+, [COc, COc, COs] for GluCd2+ and ThrCd2+, respectively. The complex energy of these conformers followed the order PheCd2+> AlaCd2+ > LeuCd2+ > GluCd2+ > GlyCd2+ > ThrCd2+. Importantly, all of the complex energy values were less than zero, indicating that these complexes could be easily dissolved in water. The Cd2+ concentration decreased with increasing amino acid concentration in aqueous solution. The complex stability constants (logβ) followed the order PheCd2+> AlaCd2+ > LeuCd2+ > GluCd2+ > GlyCd2+ > ThrCd2+, consistent with the order of the calculated complex energy values. The Cd removal efficiencies by Thr, Glu, Gly, Ala, Leu, and Phe were 38.88%, 37.47%, 35.5%, 34.72%, 34.04%, and 31.99%, respectively. In soil batch tests, the total Cd concentration in soil decreased in the presence of amino acids, while the Cd concentration in water increased from 231.97 μg/L to 652.94~793.51 μg/L. The results of sequential extraction showed that the acid-extractable fraction and the reducible fraction of Cd sharply decreased. Consequently, the significant features of amino acids along with their biocompatibility make them potentially applicable chelators in Cd-contaminated soil remediation processes.

Comparison Studies on Several Ligands Used in Determination of Cd(II) in Rice by Flame Atomic Absorption Spectrometry after Ultrasound-Assisted Dispersive Liquid-Liquid Microextraction.

Ligands plays an important role in the extraction procedures for the determination of cadmium in rice samples by using flame atomic absorption spectrometry (FAAS). In the present study, comparative evaluation of 10 commercially available ligands for formation of Cd(II)-ligand complex and determination of cadmium in rice samples by ultrasound-assisted dispersive liquid–liquid microextraction (UADLLME) combined with FAAS was developed. Sodium diethyldithiocarbamate (DDTC) provided a high distribution coefficient as well as a good absorbance signal, therefore DDTC was used as a ligand in UADLLME. A low density and less toxic solvent, 1-heptanol, was used as the extraction solvent and ethanol was used as the disperser solvent. In addition, the experimental conditions of UADLLME were optimized in standard solution first and then applied in rice, such as the type and volume of extractant and dispersant, pH, extraction time, and temperature. Under the optimal experimental conditions, the detection limit (3σ) was 0.69 μg/L for Cd(II). The proposed method was applied for the determination of Cd(II) in three different rice samples (polished rice, brown rice, and glutinous rice), the recovery test was carried out, and the results ranged between 96.7 to 113.6%. The proposed method has the advantages of simplicity, low cost, and accurate and was successfully applied to analyze Cd(II) in rice.

Synthesis, crystal structure, Hirshfeld surface analysis and molecular docking analysis of new cadmium(II) iodide complex with the pyridine, 4-(1,1-dimethylethyl)

This study was set out to introduce a newly synthesized cadmium complex, [Cd(4-tertbutyl-pyridine)2I2], where t-BP = 4-tert-butyl pyridine. The complex was synthesized and characterized using elemental analysis, X-ray diffraction, FTIR, and photoluminescence combined with DFT calculations. The X-ray analysis of (Cd(t-BP)2I2) revealed that the Cd center is approximately tetrahedrally coordinated with two nitrogen atoms from the 4-tertbutylpyridine groups and the two I ions forming an approximately tetrahedral geometry with τ4 = 0.89. The presence of various intermolecular interactions and 2 D-fingerprint regions is supported by the Hirshfeld surface analysis. In the theoretical calculations, the density functional theory (DFT) method with the PBEPBE functional, the SDD basis set for Cd and I, and the 6-311 G(d) basis set for C, N, and H at the B3LYP/LANL2DZ level were chosen as the computational method. Systems based on electronic and optical properties were also discussed. The frontier molecular orbitals (FMO) analysis, chemical activity, local reactivity descriptors (Fukui functions), and NLO properties were examined for the compound at the LANL2DZ level of theory. The Cd(II) complex was studied by using molecular docking analysis to identify the active site and binding energies with anti-cancer receptors.

The spectral characteristics and cadmium complexation of soil dissolved organic matter in a wide range of forest lands

The quality and quantity of dissolved organic matter (DOM) greatly controls the fate of heavy metals. The characteristics of DOM and its interaction with metals are essential for the metal ecological risk assessment of soils. In this study, the DOM spectral characteristics of representative forest soils and the complex capacities between fluorescent DOM components and cadmium (Cd) were analyzed. Functional groups, such as carboxylic acids, alcohols and phenols, were determined by FT-IR analysis. Chromophoric DOM, fluorescent DOM and dissolved organic carbon (DOC) concentrations exhibited strong correlations with each other, indicating that variations of DOC could be well explained by Chromophoric DOM or fluorescent DOM due to high correlation coefficients. The spectral slope ratio was in the range of 0.85–5.90, implying an abundance of heavy macromolecular humic acids, peptides, and polycondensates. The absorbance spectral at 254 nm (SUVA254) strongly correlated with SUVA260 (r = 0.992, P < 0.01), indicating that hydrophobicity closely related with aromatic structure, and aromatic groups could be broadly hydrophobic. Fluorescence indices were from 1.62 to 2.21 and biological index values ranged from 0.54 to 1.14, where the DOM was mainly sourced from mixed terrestrial and autogenous inputs in most sites. Four universal fluorescence components were identified and characterized by fluorescence EEM-PARAFAC, including two humic-like (components 1 and 2), one tyrosine-like (components 3) and one fulvic-like (components 4) component. Both components 3 and 4 showed fluorescence quenching with increasing Cd concentrations, while components 1 and 2 had no evident change in fluorescence intensity. The logK3 and logK4 values ranged from 4.41 to 5.29 and 4.71 to 5.54, respectively, with most logK values of component 3 for Cd binding being smaller than that of component 4, thus, indicating that the fulvic acid substances exhibited stronger and more stable interactions with Cd than protein-like components.

Effectiveness and mechanism for the simultaneous adsorption of Pb(II), Cd(II) and As(III) by animal-derived biochar/ferrihydrite composite

The emerging animal-derived biochar (AB) has shown potential for mitigating the contamination of cationic heavy metals, but has no affinity to oxyanionic metals. In this study, we developed an AB/ferrihydrite composite with a AB/Fe mass ratio of 4.0 (ABF-4) for the simultaneous adsorption of cationic Pb(II)/Cd(II) and anionic As(III). ABF-4 is a type of hydroxyapatite-rich biochar coated with nanoscale iron hydroxide aggregates. The adsorption of Pb(II), Cd(II), and As(III) on ABF-4 were 2.64, 1.55, and 0.48 mmol/g, and were 135%, 150%, and 4500% higher than those of pure AB, respectively. The enhanced adsorption of Pb(II) and Cd(II) by ABF-4 is partially due to the increase in surface area and micropores. The nano-sized ferrihydrite on ABF might help form surface complexation with As(III) and oxidize As(III) to As(V). In multimetal systems, Pb(II) and Cd(II) can promote As(III) adsorption due to the formation of NaPb4(AsO4)3 precipitate and the ternary complex of arsenite and cadmium with ABF-4, whereas Cd(II) adsorption might be inhibited because of the surface coverage of Pb5(PO4)3Cl precipitate on ABF-4. However, the coexistence of Pb in soils does not influence the immobilization of Cd. The amendment of ABF-4 can considerably decrease the availability of Pb, Cd, and As in soils from Pb–Zn smelting sites. Hence, ABF-4 is a promising multifunctional material for the potential immobilization of multicomponent heavy metals.

Copper(II) and cadmium(II) complexes of mono-condensed N,O- or N,N,O-Donor ligands: synthesis, crystal structures, and antibacterial activity

Three new copper(II) and cadmium(II) complexes, [Cu(L1)2] (1), [CuL2(N3)] (2), and [Cd(L3)2] (3), where L1 = 2-bromo-4-chloro-6-cyclohexylaminomethylphenolate, L2 = 2-bromo-4-chloro-6-[(2-morpholin-4-ylethylimino)methyl]phenolate, and L3 = 2-bromo-4-chloro-6-[(3-morpholin-4-ylpropylimino)methyl]phenolate, have been prepared and structurally characterized by X-ray crystallography. The Cu atom in complex 1 is in tetrahedrally distorted square planar geometry. The Cu atom in complex 2 is in square planar geometry. The Cd atom in complex 3 is in octahedral geometry. The complexes exhibited effective activities against B. subtilis, S. aureus and E. coli.

Construction of naphthalene diimide-based cadmium complexes and their application in iodine adsorption, photochromism, and photocatalysis

Two naphthalenediimide-based cadmium complexes with photochromic properties, which have the ability of iodine adsorption and good potential photocatalytic degradation activity for various dyes, were successfully prepared.

Investigating the photosensitivity of koneramines for cell imaging and therapeutic applications.

The photophysical properties of the anthracene appended koneramines (LAn) were analyzed and utilized as a chemosensor for the selective detection of Cd2+ and Zn2+. The complexation-induced inhibition of PET (photo-induced electron transfer) from the chelating nitrogen atoms to the excited state of the anthracene moiety resulted in a fluorescence "turn-on" signal upon binding with Cd2+ and Zn2+. The confocal microscopic imaging studies performed on the MCF-7 cells validated that the compound is potentially useful for detecting Cd2+ and Zn2+ inside the cells. The cadmium complex exhibited unique bactericidal activity against clinically relevant human pathogens. The excellent activity against multidrug-resistant S. aureus makes the complex useful as a new, easily synthesizable antibiotic. The cadmium complex LAnCdCl2 was not cytotoxic against vero cells with a selectivity index of 40, exhibited concentration dependent bactericidal killing, was non-interactive with several other clinically approved standard drugs, exhibited prolonged post-antibiotic effect (PAE) against S. aureus ATCC 29213 and possesses antibiofilm activity.

Synthesis, characterization and biological activities study of metal complexes of 5,6-dimethylbenzimidazole with Co(II), Cu(II), Cd(II) and Hg(II)

The present work aimed at the synthesis of cobalt(Ⅱ), copper(Ⅱ), cadmium(Ⅱ) and mercury(Ⅱ) complexes of 5,6-dimethylbenzimidazole by simple and straight forward methods. Several elemental, spectroscopic and thermal studies such as; solubility, melting point, elemental analysis, FTIR spectroscopy, UV–visible spectroscopy, magnetic susceptibility, conductivity test, TGA, DSC and XRD were carried out to characterize the synthesized complexes. Elemental analysis (C, H, N, M) data confirmed 1:2 metal to ligand ratio represented as [M(L)2Cl2]. UV–visible spectra and Magnetic susceptibility values suggested tetrahedral geometry of the synthesized metal complexes. The lattice types were predicted by XRD data and conductivity values indicated non-electrolytic nature of the complexes. TGA and DSC data demonstrated their thermal decomposition patterns as well as formation of corresponding metal oxides. Combining all the analytical results, the proposed empirical formulae of the complexes are [Co(C9H10N2)2Cl2], [Cu(C9H10N2)2Cl2], [Cd(C9H10N2)2Cl2] and [Hg(C9H10N2)2Cl2]. The synthesized complexes were also subjected to antimicrobial and cytotoxicity activity screening. Cd(II) and Hg(II) complexes showed activity against both gram positive and negative bacterial strains at relatively higher concentration. Most of the complexes were less or insensitive to bacterial and fungal strains at lower concentration. All of the synthesized complexes exhibited potential cytotoxic activity.

Efekti kadmijuma na transportne procese u proksimalnim tubulskim ćelijama bubrega

Cadmium (Cd) is an extremely toxic metal that is widespread in nature. Due to its favorable properties, it was widely used in the industry for the production of alkaline batteries, accumulators, pigments, and colored alloys. However, it has been shown that exposure to low concentrations of cadmium leads to damage to many organs and organ systems, and the use of this metal in industry is reduced, and it is replaced by other, less harmful materials. Today, fossil fuel combustion and cigarette consumption are important sources of cadmium exposure. Numerous studies have examined the toxic effects of cadmium and they highlight the kidneys, liver, gonads as the organs that suffer the most damage. The kidneys, as the main place of cadmium storage in the body, are mostly exposed to its toxic effects. In the proximal tubular cells of the kidney, exposure to cadmium disrupts transport processes. Although ionized cadmium (Cd 2+) is thought to be largely responsible for the damage that occurs, the role of the cadmium and metallothionein complex (Cd-MT) cannot be ignored. Peritubular exposure to ionized cadmium indirectly leads to a decrease in the activity of the Na + /L-alanine cotransporter and a decrease in the rate of slow repolarization of the luminal membrane, while the Cd-MT complex leads to both direct and indirect inhibition of this transporter. Also, the Cd-MT complex inhibits Na + /Glucosa cotransporter activity. Exposure to cadmium also leads to a decrease in the endocytic uptake of low molecular weight proteins, which is accompanied by microalbuminuria.

Dodecahydro-Closo-Dodecaborate Anion in Zinc(Ii) and Cadmium(Ii) Complexation at the Presence of N-Donor Heterocyclic Ligands

Dodecahydro-Closo-Dodecaborate Anion in Zinc(Ii) and Cadmium(Ii) Complexation at the Presence of N-Donor Heterocyclic Ligands

A New 2d-Open-Framework Cadmium (Ii) Complex Templated by 1,4-Bis(3-Aminopropyl)Piperazine: Crystal Structure, Optical Properties, Theoretical and Biological Study

A New 2d-Open-Framework Cadmium (Ii) Complex Templated by 1,4-Bis(3-Aminopropyl)Piperazine: Crystal Structure, Optical Properties, Theoretical and Biological Study

Cadmium(II) and copper(II) complexes containing benzoate derivatives and 2-aminopyrimidine ligands: Synthesis, crystal structures and antibacterial activity

The new Cd(II) and Cu(II) complexes namely [Cd2(2-OHbza)4(apm)4] (1), [Cu2(2-OHbza)4(apm)]n•2(2-OHbza) (2) and [Cu2(2-CH3bza)4(apm)]n (3) (2-OHbza = 2-hydroxybenzoate, 2-CH3bza = 2-methylbenzoate and apm = 2-aminopyrimidine) were successfully prepared by using direct one pot synthesis method. All complexes were characterized by using CHN elemental analysis, FT-IR spectroscopy, powder X-ray diffraction and single crystal X-ray diffraction techniques. Compound 1 crystallized in monoclinic space group P21/c, while compound 2 and 3 crystallized in triclinic space group P-1. The dinuclear compound 1 consists of two seven-coordinated Cd(II) centers which are doubly bridged by 2-OHbza bridging ligands, while the rest two 2-OHbza and two apm are terminal ligand. The crystal structure of compound 1 is stabilized by the intermolecular hydrogen bonding and C-H•••π interaction and π•••π interactions. Compounds 2 and 3 present zigzag one-dimensional chainlike-structure which dimer Cu(II) units are linked by apm ligand. The crystal structure of these compounds is stabilized by π•••π and C-H•••π interactions. The photoluminescence properties of compound 1 has been studied comparing to those of 2-OHbza and apm ligands. The solid state PL emission spectrum of compound 1 shows similar intensity of free apm ligand and shape to free 2-OHbza ligand which present a single broad band centered at λem 525 nm (λex = 325 nm), but blue-shift. For solution PL experiment of compound 1 in various solvents, the results showed that compound 1 is selective PL quenching acetone. Electronic spectra for solid state and solution in different solvents of compounds 2 and 3 present the d-d absorption bands centered in the range of 701 – 794 nm. The highest red shifts of λmax are found for compounds 2 and 3 in DMSO. In addition, the antibacterial activity of all compounds are investigated for S.aureus and E.coil by agar diffusion method. The results show that compound 1 exhibits the activity against S.aureus better than E.coil.

In-silico docking, synthesis, structure analysis, DFT calculations and energy frameworks of metal complexes to regress angiogenesis activity

Angiogenesis is the formation of new blood vessels and capillaries from pre-existing blood vessels. In general, it plays an important role in the development of tumors, as tumors never grow beyond 2 to 3 mm without angiogenesis processes which supply the essential nutrient to the tumor. Therefore, blocking the angiogenesis process is one of the promising strategies to inhibit cancer cell growth. Metals are essential for several biochemical reactions in living organisms. It is a cellular component selected by nature to function in many biological processes. Metal complexes show a broad range of pharmacological activity and considerable efforts are made for the development of metal complexes as drugs. Encouraged by this information, the metal complexes of Cobalt(II), Nickel(II), Zinc(II), Cadmium(II), and Copper(II) derivative of N, N’ Bis-(3,4,5-trimethoxy benzylidene)–benzene–1,2-diamine have been synthesized from o-phenylene diamine in the alcoholic medium. The metal complexes (M1−M5) were characterized using different techniques like 1H NMR, Fourier-transform infrared spectral data, mass spectral data, thermo gravimetric studies, magnetic susceptibility data, molar conductance, ESR, and micro-elemental analysis. The result obtained from the characterization results reveals that all the metal complexes (M1−M5) obtained were square planar except one which was octahedral configuration. The DNA binding, cleavage and anti-angiogenesis activity shown by the complexes (M1−M5) were significantly better than the ligand. Also, complexes M2 and M3 showed the highest anti-angiogenic activity and decreasing intensity of lane as compared with other synthetic complexes. In-silico docking simulations predicted the anti-angiogenesis activity of the complexes against homo sapiens of VEGFR-2 and exhibited prominent interactions at the active site pocket region. Moreover, density functional theory (DFT) was applied to calculate HOMO-LUMO, energy gap, and other parameters under PBE1PBE functional with lanl2dz basis sets.

Synthesis, spectral characterization and antibacterial activity of transition metal (II) complexes of tetradentate Schiff base ligand

Nickel, zinc and cadmium complexes of a Schiff base derived from 4-nitro-o-phenylenediamine and 5-methoxysalicylaldehyde were synthesized and characterized using infrared, ultra violet, molar conductance measurements and nuclear magnetic resonance spectroscopy. Tetradentate schiff base complexes are widely used for the industrial purpose and also exhibit the wide range of biological activities. Hence the antibacterial activity of the Schiff base ligand and the metal complexes against some clinically important bacteria namely Escherichia coli, Proteus mirabilis, Streptococcus pneumoniae, Bacillus subtilis were investigated and the obtained results have shown that the complexes were possesses more antibacterial activity than the parent Schiff base ligand and hence could be potentially used in the preparation of anti bacterial agents.

Synthesis, characterization, and biological activity of cadmium (II) and antimony (III) complexes based on 2-acetylpyrazine thiosemicarbazones

Two cadmium (II) complexes formulated as [Cd(L1)(HL1)]ClO4 (Cd1) and [Cd(L2)2] (Cd2), also two antimony (III) complexes formulated as [Sb(L1)2]2Cl2·CH3OH (Sb1) and [Sb(L2)Cl2] (Sb2) (HL1 = 2-acetylpyrazine N4-methylthiosemicarbazone, HL2 = 2-acetylpyrazine N4-dimethylthiosemicarbazone) have been synthesized, and the molecular structure of the four complexes have been determined by single crystal X-ray diffraction. The antimicrobial study has been conducted against E. coli and S. aureus, and the results indicated that the antibacterial activity of Cd1 and Sb1 increased to some extent than their ligand HL1, while Cd2 and Sb2 presented fairly effective antibacterial activity mainly the same as their ligand HL2. The four compounds all exhibited improved cytotoxic activity against the human hepatocellular carcinoma HepG2 cells than the ligands. While Cd2 displayed the most effective antiproliferative activity, and also the preferable selectivity for HepG2 cells versus normal QSG7701 cells. It is noted that there was a strong relationship between the activity of the ligand HL2 and its cadmium (Ⅱ) or antimony (III) complexes.

Synthesis of new cadmium(II) complexes of Schiff bases as alkaline phosphatase inhibitors and their antimicrobial activity

The present investigation deals with the synthesis, characterization and pharmacological evaluation of four cadmium complexes ( 1 – 4 ) with Schiff bases ( 1 L- 4 L) derived from the substituted amines and aryl aldehydes. Amantadine is reacted with different aryl aldehydes (salicylaldehyde, 3-ethoxysalicylaldehyde and 4-(diethylamino) salicylaldehyde) to prepare Schiff base ligands 1 L- 3 L, while 4 L was prepared using 4-methylaniline. The complexes were characterized by elemental analysis, spectroscopic techniques and thermal analysis, and the structure of one of the ligands, 3 L was determined by X-ray crystallography. The spectroscopic data indicate that the ligands coordinate with Cd(II) in a bidentate fashion to give octahedral geometry. Single crystal XRD analysis shows that 3 L is orthorhombic with the space group P2 1 2 1 2 1 . The ligands and their Cd(II) complexes were evaluated for antimicrobial activities, while the complexes were also investigated for inhibition effects towards an enzyme, alkaline phosphatase. The anti-microbial screening results showed that cadmium complex 1 exhibited significant antibacterial potential, particularly against Staphylococcus aureus with respect to the corresponding ligand suggesting that the complexes are more effective than their ligands for antimicrobial activity. In case of alkaline phosphatase inhibition screening, the synthesized cadmium complex 1 was found to maximally inhibit the activity of alkaline phosphatase in comparison to rest of three complexes.

Synthesis and preliminary biological evaluation of antibacterial and antifungal 5-arylidene tetramic acid-cadmium(II) complexes.

The synthesis and biological evaluation of 5-arylidene-N-acetyl-tetramic acids cadmium(II) complexes are reported. Eleven novel compounds were prepared, characterized by nuclear magnetic resonance experiments and screened for their antimicrobial activity against five bacterial species (Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and methicillin-resistant Staphylococcus aureus [MRSA]) and two fungi (Candida albicans and Cryptococcus neoformans). The complexes showed similar or enhanced activities against MRSA in comparison to the corresponding ligands and, additionally, promising antifungal activities against C. neoformans. The most active compounds 3c and 3h showed remarkable activities against MRSA (minimum inhibitory activity [MIC] values of 32 and 4 μg/ml, respectively) and C. neoformans (MIC values of 8 and 16 μg/ml, respectively), accompanied by no human cell toxicity and hemolytic activity within the tested concentration range. The results demonstrate that appropriately functionalized tetramic acids attached with lipophilic alkanoyl chain andafter complexation with cadmium(II) ions may act as valuable lead compounds for further investigations towardthe development of novel antibacterial and/or antifungal agents.