This article examines the potential offered by the use of interconnections in reconfiguring the relationship between infrastructure-oriented policies and regional land use policies, through analyzing the various forms of action being carried out at interconnection nodes. The concept of interconnection, which provides tremendous insight into operational aspects, is applied in order to determine the spatial dimensions of infrastructure networks. The article forwards the hypothesis that each specific type of project corresponds to a distinct form of interconnection: - the interconnection of physical networks, which concerns above all node-related projects (train stations, subway stations, etc.), « systems » designed to both facilitate access to networks and connect networks with the local spatial layout ; - interconnection as reflected in a large-scale local-level project, able to incorporate the various local settings being networked, by capitalizing on both the tangible and intangible relationships developed between exchange centers ; - interconnection among actors (both institutional and non-institutional) with respect to the decision-making system, through establishing new expressions of negotiation and coordination for overcoming project-related deficiencies. These three formats, which highlight the role played by interconnection in redefining the relationship between infrastructure-oriented policies and land use policies at the regional level, are then exhibited through three planning programs drawn from Italian experience : - the Modena train station rehabilitation project (a physical network interconnection) ; - regional development policy, in conjunction with forecasted infrastructure-related needs, in Lombardy (interconnection via a large-scale regional project) ; - the northern Milan bypass road project, first proposed in the 1960' s yet still not completed (Gronda Intermedia) (interconnection among actors).