With the development of Chengdu Economic Zone, practical business English talents are badly needed. Thus, the training objective for business English majors in Leshan Normal University should be Chengdu Economic Zone oriented to cultivate professionals with both business skills and English competence who can fluently use English to cope with business affairs. However, through the surveys of companies and enterprises in the Zone as well as the graduates in the university, it is found that the business English professional graduates still fail to fully meet the demand of the companies. There are still some problems in the practical training system in the university, such as sufficient practical training bases, lack of teaching staff with bi-expertise, and imperfect management and evaluation system for the practical teaching. The paper aims to study the construction of practical teaching system in business English major which can not only ensure the cultivation of satisfactory practical business English talents but also improve the graduates’ competitiveness.