Therefore, the burden of diabetic foot ulcers is significantly increasing and it is now considered as a leading cause of infection, amputation, and hospitalization in patients with diabetes mellitus [3]. Management of foot ulcers remains a major health challenge and different treatment options are currently available for it. Therefore, it seems necessary that the effectiveness of different treatment options should be rigorously assessed. Currently, several different interventions for treatment of DFUs are available such as: wound debridement, antibiotics, different wound dressings, topical negative pressure, hyperbaric oxygen treatment, electrical interventions, electromagnetic options, laser, shockwave, and ultrasound therapies, growth and cell biology factors, cell products and tissue engineering, bioengineered skin and skin grafts, and adjuvant therapies [4]. As a result of interdisciplinary approaches in medicine, physics, chemistry, biology and microbiology, plasma medicine has emerged as an innovative and dynamic field of research in the recent years.
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