Proton Bunch Research Articles

Proton bunch monitors for the clinical translation of prompt gamma-ray timing

Objective. Prompt gamma-ray timing is an emerging technology in the field of particle therapy treatment verification. This system measures the arrival times of gamma rays produced in the patient body and uses the cyclotron radio frequency signal as time reference for the beam micro-bunches. Its translation into clinical practice is currently hindered by observed instabilities in the phase relation between the cyclotron radio frequency and the measured arrival time of prompt gamma rays. To counteract this, two proton bunch monitors are presented, integrated into the prompt gamma-ray timing workflow and evaluated.Approach. The two monitors are (a) a diamond detector placed at the beam energy degrader, and (b) a cyclotron monitor signal measuring the phase difference between dee current and voltage. First, the two proton bunch monitors as well as their mutual correlation were characterized. Then, a prompt gamma-ray timing measurement was performed aiming to quantify the present magnitude of the phase instabilities and to evaluate the ability of the proton bunch monitors to correct for these instabilities.Main results. It was found that the two new monitors showed a very high correlation for intermediate proton energies after the first second of irradiation, and that they were able to reduce fluctuations in the detected phase of prompt gamma rays. Furthermore, the amplitude of the phase instabilities had intrinsically decreased from about 700 ps to below 100 ps due to cyclotron upgrades.Significance. The uncertainty of the prompt gamma-ray timing method for proton treatment verification was reduced. For routine clinical application, challenges remain in accounting for detector load effects, temperature drifts and throughput limitations.

Absolute energy-dependent scintillating screen calibration for real-time detection of laser-accelerated proton bunches.

Laser-plasma accelerators (LPAs) can deliver pico- to nanosecond long proton bunches with ≳100 nC of charge dispersed over a broad energy spectrum. Increasing the repetition rates of today's LPAs is a necessity for their practical application. This, however, creates a need for real-time proton bunch diagnostics. Scintillating screens are one detector solution commonly applied in the field of electron LPAs for spatially resolved particle and radiation detection. Yet their establishment for LPA proton detection is only slowly taking off, also due to the lack of available calibrations. In this paper, we present an absolute proton number calibration for the scintillating screen type DRZ High (Mitsubishi Chemical Corporation, Düsseldorf, Germany), one of the most sensitive screens according to calibrations for relativistic electrons and x rays. The presented absolute light yield calibration shows an uncertainty of the proton number of 10% and can seamlessly be applied at other LPA facilities. For proton irradiation of the DRZ High screen, we find an increase in light yield of >60% compared to reference calibration data for relativistic electrons. Moreover, we investigate the scintillating screen light yield dependence on proton energy since many types of scintillators (e.g., plastic, liquid, and inorganic) show a reduced light yield for increased local energy deposition densities, an effect termed ionization quenching. The ionization quenching can reduce the light yield for low-energy protons by up to ∼20%. This work provides all necessary data for absolute spectral measurements of LPA protons with DRZ High scintillating screens, e.g., when used in the commonly applied Thomson parabola spectrometers.

Design and Implementation of an Energy Selector for Laser-Accelerated Protons

Highly intense bunches of protons and ions with energies of several MeV/u can be generated with ultra-short laser pulses focused on solid targets. In the most common interaction regime, target normal sheath acceleration, the spectra of these particles are spread over a wide range following a Maxwellian distribution. We report on the design and testing of a magnetic chicane for the selection of protons within a limited energy window. This consisted of two successive, anti-parallel dipole fields generated by cost-effective permanent C-magnets with customized configuration and longitudinal positions. The chicane was implemented into the target vessel of a petawatt laser facility with constraints on the direction of the incoming laser beam and guidance of the outgoing particles through a vacuum port. The separation of protons and carbon ions within distinct energy intervals was demonstrated and compared to a ray tracing code. Measurements with radiochromic film stacks indicated the selection of protons within [2.4, 6.9] MeV, [5.0, 8.4] MeV, or ≥6.9 MeV depending on the lateral dispersion. A narrow peak at 4.8 MeV was observed with a time-of-flight detector.

Prompt gamma timing for proton range verification with TlBr and TlCl as pure Cherenkov emitters

Objective. Prompt gamma timing (PGT) uses the detection time of prompt gammas emitted along the range of protons in proton radiotherapy to verify the position of the Bragg peak (BP). Cherenkov detectors offer the possibility of enhanced signal-to-noise ratio (SNR) due to the inherent physics of Cherenkov emission which enhances detection of high energy prompt gamma rays relative to other induced uncorrelated signals. In this work, the PGT technique was applied to 3 semiconductor material slabs that emit only Cherenkov light for use in a full scale system: a 3 × 3 × 20 mm3 TlBr, a 12 × 12 × 12 mm3 TlBr, and a 5 × 5 × 5 mm3 TlCl. Approach. A polymethyl methacrylate (PMMA) target was exposed to a 67.5 MeV, 0.5 nA proton beam and shifted in 3 mm increments at the Crocker nuclear laboratory (CNL) in Davis, CA, USA. A fast plastic scintillator coupled to a photomultiplier tube (PMT) provided the start reference for the proton time of flight. Time of flight (TOF) distributions were generated using this reference and the gamma-ray timestamp in the Cherenkov detector. Main results. The SNR of the proton correlated peaks relative to the background was 20, 29, and 30 for each of the three samples, respectively. The upper limit of the position resolutions with the TlCl sample were 2 mm, 3 mm, and 5 mm for 30k, 10k, and 5k detected events, respectively. The time distribution of events with respect to the reference reproduced with clarity the periodicity of the beam, implying a very high SNR of the Cherenkov crystals to detect prompt gammas. Background presence from the neutron-induced continuum, prompt gammas from deuterium, or positron activation were not observed. Material choice and crystal dimensions did not seem to affect significantly the outcome of the results. Significance. These results show the high SNR of the pure Cherenkov emitters TlBr and TlCl for the detection of prompt gammas in a proton beam with current of clinical significance and their potential for verifying the proton range. The accuracy in determining shifts of the BP was highly dependent on the number of events acquired, therefore, the performance of these detectors are expected to vary with different beam conditions such as current, pulse repetition, and proton bunch width.

Filamentation of a relativistic proton bunch in plasma.

We show in experiments that a long, underdense, relativistic proton bunch propagating in plasma undergoes the oblique instability, which we observe as filamentation. We determine a threshold value for the ratio between the bunch transverse size and plasma skin depth for the instability to occur. At the threshold, the outcome of the experiment alternates between filamentation and self-modulation instability (evidenced by longitudinal modulation into microbunches). Time-resolved images of the bunch density distribution reveal that filamentation grows to an observable level late along the bunch, confirming the spatiotemporal nature of the instability. We provide a rough estimate of the amplitude of the magnetic field generated in the plasma by the instability and show that the associated magnetic energy increases with plasma density.

Hosing of a Long Relativistic Particle Bunch in Plasma.

Experimental results show that hosing of a long particle bunch in plasma can be induced by wakefields driven by a short, misaligned preceding bunch. Hosing develops in the plane of misalignment, self-modulation in the perpendicular plane, at frequencies close to the plasma electron frequency, and are reproducible. Development of hosing depends on misalignment direction, its growth on misalignment extent and on proton bunch charge. Results have the main characteristics of a theoretical model, are relevant to other plasma-based accelerators and represent the first characterization of hosing.

Uniform onset of the long proton bunch self-modulation seeded by an electron bunch in an overdense plasma

Uniform onset of the long proton bunch self-modulation seeded by an electron bunch in an overdense plasma

A compact low energy proton source.

A low energy proton source for non-neutral plasma experiments was developed. Electrons from a hot filament ionize H2 gas inside a geometrically compensated Penning trap to produce protons via dissociative ionization. A rotating wall electric field destabilizes the unwanted H2+ and H3+ generated in the process while concentrating protons at the center of the trap. The source produces bunches of protons with relatively low ion contamination (5.5% H2+ and 15.5% H3+), with energy tunable from 35 to 300eV.

Development of the self-modulation instability of a relativistic proton bunch in plasma

Self-modulation is a beam–plasma instability that is useful to drive large-amplitude wakefields with bunches much longer than the plasma skin depth. We present experimental results showing that, when increasing the ratio between the initial transverse size of the bunch and the plasma skin depth, the instability occurs later along the bunch, or not at all, over a fixed plasma length because the amplitude of the initial wakefields decreases. We show cases for which self-modulation does not develop, and we introduce a simple model discussing the conditions for which it would not occur after any plasma length. Changing bunch size and plasma electron density also changes the growth rate of the instability. We discuss the impact of these results on the design of a particle accelerator based on the self-modulation instability seeded by a relativistic ionization front, such as the future upgrade of the Advanced WAKefield Experiment.

A laser proton accelerator targeting tumors in mice

High-power short-pulse lasers can generate intense but fluctuating bunches of energetic protons. We demonstrate a new level of stability for laser-driven proton sources that allowed us to successfully perform the world-wide first tumor irradiation study in mice with this novel radiation source.

Technical note: Measurement of the bunch structure of a clinical proton beam using a SiPM coupled to a plastic scintillator with an optical fiber.

Recent proposals of high dose rate plans in protontherapy as well as very short proton bunches may pose problems to current beam monitor systems. There is an increasing demand for real-time proton beam monitoring with high temporal resolution, extended dynamic range and radiation hardness. Plastic scintillators coupled to optical fiber sensors have great potential in this context to become a practical solution towards clinical implementation. In this work, we evaluate the capabilities of a very compact fast plastic scintillator with an optical fiber readout by a SiPM and electronics sensor which has been used to provide information on the time structure at the nanosecond level of a clinical proton beam. A 3×3×3mm3 plastic scintillator (EJ-232Q Eljen Technology) coupled to a 3×3mm2 SiPM (MicroFJ-SMA-30035, Onsemi) has been characterized with a 70 MeV clinical proton beam accelerated in a Proteus One synchrocyclotron. The signal was read out by a high sampling rate oscilloscope (5 GS/s). By exposing the sensor directly to the proton beam, the time beam profile of individual spots was recorded. Measurements of detector signal have been obtained with a time sampling period of 0.8 ns. Proton bunch period (16 ns), spot (10 μs) and interspot (1 ms) time structures could be observed in the time profile of the detector signal amplitude. From this, the RF frequency of the accelerator has been extracted, which is found to be 64 MHz. The proposed system was able to measure the fine time structure of a clinical proton accelerator online and with ns time resolution.

Progress report on Muon Source Project at CSNS

A Muon station for sciEnce, technoLOgy and inDustrY (MELODY) has been listed in the China Spallation Neutron Source upgrade plan, and the infrastructure construction is scheduled to start by the end of 2022. The 1.6 GeV double-pulsed proton bunch will be extracted from the Rapid Cycling Synchrotron (RCS) ring to a stand-alone target station. One surface muon and one decay muon beamline are designed to provide multi-terminals for applications. In this report, we describe the design of MELODY and prospect for future applications.

Numerical studies of a layered lithium-boron target for laser-driven aneutronic fusion reactions

This paper explores a novel target design for laser-driven, aneutronic, proton-boron and proton-lithium fusion reactions consisting of a stack of boron and lithium foils. In contrast to a homogeneous target, this multi-layer setup provides additional fusion channels in the different materials. The composition of the layers is chosen in descending order of the fusion reactions' thresholds, facilitating the fusion of protons that penetrate further into the material despite their energy losses due to electronic and nuclear stopping power. We employ a combination of Fluka simulations and additional numerical computations to evaluate thousands of target configurations. Four different beam energy distributions are considered: two Gaussian distributions with 6~MeV and 10~MeV mean energies, respectively, a Maxwell-Boltzmann distribution and a power law distribution. We explore the production of energy in a range of layer thicknesses motivated by the proton ranges based on ionization losses. The configuration which maximizes the produced energy for each beam type is reported. The production of fusion energy ranges from hundreds to thousands of millijoules for proton bunches of $10^{15}$ having mean energies between 2-10 MeV.

A beam position monitor for electron bunch detection in the presence of a more intense proton bunch for the AWAKE Experiment

The Advanced Proton Driven Plasma Wakefield Experiment (AWAKE) at CERN uses 6 cm long proton bunches extracted from the Super Proton Synchrotron (SPS) at 400 GeV beam energy to drive high gradient plasma wakefields for the acceleration of electron bunches to 2 GeV within a 10 m length. Knowledge and control of the position of both copropagating beams is crucial for the operation of the experiment. Whilst the current electron beam position monitoring system at AWAKE can be used in the absence of the proton beam, the proton bunch signal dominates when both particle bunches are present simultaneously. A new technique based on the generation of Cherenkov diffraction radiation (ChDR) in a dielectric material placed in close proximity to the particle beam has been designed to exploit the large bunch length difference of the particle beams at AWAKE, 200 ps for protons versus a few ps for electrons, such that the electron signal dominates. Hence, this technique would allow for the position measurement of a short electron bunch in the presence of a more intense but longer proton bunch. The design considerations, numerical analysis and plans for tests at the CERN Linear Electron Accelerator for Research (CLEAR) facility are presented.

Three-dimensional acoustic monitoring of laser-accelerated protons in the focus of a pulsed-power solenoid lens

Abstract The acoustic pulse emitted from the Bragg peak of a laser-accelerated proton bunch focused into water has recently enabled the reconstruction of the bunch energy distribution. By adding three ultrasonic transducers and implementing a fast data analysis of the filtered raw signals, I-BEAT (Ion-Bunch Energy Acoustic Tracing) 3D now provides the mean bunch energy and absolute lateral bunch position in real-time and for individual bunches. Relative changes in energy spread and lateral bunch size can also be monitored. Our experiments at DRACO with proton bunch energies between 10 and 30 MeV reveal sub-MeV and sub-mm resolution. In addition to this 3D bunch information, the signal strength correlates also with the absolute bunch particle number.

OCTOPOD: single-bunch tomography for angular-spectral characterization of laser-driven protons

Abstract Laser–plasma accelerated (LPA) proton bunches are now applied for research fields ranging from ultra-high-dose-rate radiobiology to material science. Yet, the capabilities to characterize the spectrally and angularly broad LPA bunches lag behind the rapidly evolving applications. The OCTOPOD translates the angularly resolved spectral characterization of LPA proton bunches into the spatially resolved detection of the volumetric dose distribution deposited in a liquid scintillator. Up to 24 multi-pinhole arrays record projections of the scintillation light distribution and allow for tomographic reconstruction of the volumetric dose deposition pattern, from which proton spectra may be retrieved. Applying the OCTOPOD at a cyclotron, we show the reliable retrieval of various spatial dose deposition patterns and detector sensitivity over a broad dose range. Moreover, the OCTOPOD was installed at an LPA proton source, providing real-time data on proton acceleration performance and attesting the system optimal performance in the harsh laser–plasma environment.

A method for obtaining 3D charge density distribution of a self-modulated proton bunch

The Advanced Wakefield Experiment (AWAKE) at CERN is the first plasma wakefield accelerator experiment to use a proton bunch as driver. The long bunch undergoes seeded self-modulation (SSM) in a 10 m-long plasma. SSM transforms the bunch into a train of short micro-bunches that resonantly drive high-amplitude wakefields. We use optical transition radiation (OTR) and a streak camera to obtain time-resolved images of the bunch transverse charge density distribution in a given plane. In this paper we present a method to obtain 3D images of the bunch by scanning the OTR across the entrance slit of the streak camera. Reconstruction of the 3D distribution is possible because with seeding self-modulation is reproducible. The 3D images allow for checking the axi-symmetry of SSM and for detecting the possible presence of the non-axi-symmetric hosing instability (HI).

Simulation study of quasi-monoenergetic high-energy proton beam based on multiple laser beams driving

High-energy proton beams have extensive and important applications. Traditional proton accelerators are bulky and costly. The high-power laser pulse technology provides a new proton acceleration scheme based on the interaction between laser and plasma, and has the advantage of miniaturization. Furthermore, comparing with traditional proton accelerators, the proton acceleration gradient by high-power laser pulses can be increased by three orders of magnitude. The proton beams with high brightness, narrow pulse width, and good directionality can be generated in theory within a very small effective size, and they are suitable for fields such as nuclear physics and particle physics, ion beam fast ignition, medical treatment, and proton beam detection. In order to realize laser proton acceleration, a great many of researches of different target configurations and acceleration mechanisms have been reported on proton acceleration driven by ultrashort and high-power lasers. However, owing to the limitation of laser intensity, the energy of proton beam driven by a single-beam laser is difficult to improve to meet the needs of medical applications. In this paper, a new method of driving proton acceleration by multiple ultrashort high-power lasers with grazing incidence on both sides of the microstrip target is proposed. A proton beam with an energy divergence of about 3% and energy of about 165 MeV can be obtained by using the two-beam driving setting. The results of two-dimensional particle-in-cell simulation show that a large number of collimated high-energy electron charges are extracted from both sides of the solid target by laser and injected into the back of the target. A longitudinal bunching field is established on the back of the target, which drives protons to accelerate and bunch to form a quasi-monoenergetic high-energy proton beam. The research also shows that the proton beam with an energy divergence of about 2% and energy of about 250 MeV can be obtained by using four grazing ultrashort high-power lasers on both sides of the microstrip target. The mechanism of multi-laser beams driving proton acceleration provides a new idea for the energy enhancement of the proton beam, and the quasi-monoenergetic high-energy proton beam is expected to be applied to the field of medical treatment.

Electron conditioning of technical surfaces at cryogenic and room temperature in the 0–1 keV energy range

In the superconducting magnets of the Large Hadron Collider (LHC) at CERN, most of the beam-induced heat load is intercepted by a beam-screen (BS) cryogenically cooled to 5–20 K. When circulating the bunched proton beam, an electron cloud (EC) can form and bombard the BS copper surface with high doses of predominantly low-energy electrons, which desorb gas and consequently increase the pressure. The beam-induced pressure rise decreases during operation as the electron irradiation diminishes the secondary electron yield (SEY) and the electron-stimulated desorption (ESD) yield, a phenomenon referred to as ‘beam conditioning’. Low ESD and SEY values achieved rapidly are requisite to mitigate EC and maintain UHV in storage rings. We report data on ESD and SEY electron conditioning completed at cryogenic temperature with 0–1 keV electrons up to an electron dose of 5.10−3 C mm−2. Our results show that SEY conditioning depends on the primary electron energy and also that ESD yield significantly decreases with temperature. At 15 K, the amorphous-carbon coating and laser-treated copper present SEY below 1.1 and have initial ESD yields 3–6 times lower than OFE copper. Our results conform to the SEY and ESD's general understanding and extend it towards cryogenic temperatures.

Analyzing the filamentation of MeV-range proton bunches in a laser-driven ion beamline and optimizing their peak intensity

In this article, we report on the latest investigations and achievements in proton beam shaping with our laser-driven ion beamline at GSI Helmholtzzentrum f\"ur Schwerionenforschung GmbH. This beamline was realized within the framework of the Laser Ion Generation, Handling, and Transport (LIGHT) collaboration to study the combination of laser-driven ion beams with conventional accelerator components. At its current state, the ions are accelerated by the high-power laser PHELIX via target normal sheath acceleration, and two pulsed high-magnetic solenoids are used for energy selection, transport, and transverse focusing. In between the two solenoids, there is a rf cavity that gives the LIGHT beamline the capability to longitudinally manipulate and temporally compress ion bunches to sub-nanosecond durations. To get optimal results, the rf cavity has to be synchronized with the PHELIX laser and therefore a reliable measurement of the temporal ion beam profile is necessary. In the past, these measurements showed unexpected correlations between the temporal beam profile and the phase as well as the electric field strength of the cavity. In this article, we present a numerical simulation of the beam transport through the LIGHT beamline which explains this behavior by a beam filamentation. We also report on our latest experimental campaigns, in which we combined transverse and longitudinal focusing for the first time. This led to proton bunches with a peak intensity of $(3.28\ifmmode\pm\else\textpm\fi{}0.24)\ifmmode\times\else\texttimes\fi{}{10}^{8}\text{ }\text{ }\mathrm{protons}/({\mathrm{ns}\text{ }\mathrm{mm}}^{2})$ at a central energy of ($7.72\ifmmode\pm\else\textpm\fi{}0.14$) MeV. The intensity refers to a circle with a diameter of ($1.38\ifmmode\pm\else\textpm\fi{}0.02$) mm that encloses 50% of the protons in the focal spot at the end of the beamline. The temporal bunch width at this position was ($742\ifmmode\pm\else\textpm\fi{}40$) ps (FWHM).