Purpose: This study is a development of previous studies that focused on testing building performance from the aspect of building comfort. A house is a place to live that is used daily that must meet the needs of the occupants' thermal comfort which is greatly influenced by environmental and building conditions, such as natural lighting, air flow, and thermal performance as well as the conditions of the building's orientation layout and space openings. To determine the thermal performance of a building, it is necessary to conduct several analyses of several parameters of air temperature, air circulation and thermal conditions that occur in buildings in several conditions of building layout or orientation and openings made. Theoretical reference: Adaptive buildings are buildings that have adaptation to external environmental conditions, occupant needs and building operational conditions with the aim of increasing energy efficiency, comfort and sustainability. These adaptive buildings are able to provide a more comfortable environment, flexible and efficient space by maximizing natural ventilation and using building materials that function as insulation against temperature and solar radiation. Method: To determine the thermal comfort conditions of the building, it is necessary to conduct several tests on several parameters, such as natural lighting, air flow, and thermal performance using several analyzes such as solar analysis, air movement analysis and thermal analysis of the planned building prototype with several alternative building orientations. To test the thermal performance of the building, solar analysis and thermal analysis are carried out using Revit-based computational fluid dynamics (CFD). Results and Conclusions: The results of the study showed that the influence of building orientation and opening placement patterns will produce several different thermal performances. And the optimal results obtained from this adaptive strategy were that the optimal heat generated caused heat generation in the envelope of 0.76 kW/m2, meaning that by considering the heat transfer value of the building envelope not exceeding 35 W/m2 (SNI 6389:2020), a wall envelope made of 10 cm thick calciboard with air holes was used to withstand the rate of heat flow into the room. Research implications: As part of the adaptive building context that supports the field of knowledge and practice in the fields of architecture, engineering and the environment, it has positive implications related to the flexibility of spatial arrangement to adjust to the needs of occupants' space, the use of more efficient and environmentally friendly building technology and materials according to the needs of adaptive buildings, and the adjustment of natural ventilation strategies according to local climate potential. Originality/value: The components that distinguish this research from previous research can be seen from the various approaches and innovations carried out by the author, namely: Adaptive Design Method: developing the functionality of spatial arrangements in post-disaster residential buildings that apply the principles of spatial efficiency and arrangement to improve more dynamic relationships between spaces and their relationships with the surrounding environment. Use of New and Data-based Technology: applying new technology in ways to monitor and control the quality of space with the surrounding environment that affects it in real-time. Using technology applications for data analysis, modeling and predicting the performance of post-disaster residential buildings according to environmental and building parameters that affect them, and using big data analysis to understand the thermal behavior of buildings to optimize building design and operations.