The present work presents studies on the morphology and structure properties of the mesocellular silica foam (MCF) with the adsorbed proteins, i.e. bovine serum albumin and ovalbumin. The equilibrium and kinetic measurements of albumin sorption were carried out. Several techniques were applied for investigation of surface, structural, morphological properties of the MCF material without and with the adsorbed protein (potentiometric titration, UV–Vis diffuse reflectance spectroscopy, nitrogen adsorption/desorption, atomic force microscopy, optical profilometer, transmission electron microscopy, and energy dispersive X-ray spectroscopy). Stronger and quicker adsorption was observed for larger BSA molecules in the case of MCF support with larger pores, which may be correlated with its conformational change or reorientation. The change of electrochemical properties into amphiphilic was found after protein adsorption, pHPZC was moved towards higher pH values. The silica surface after albumin adsorption became less porous and rough, smoother and more homogeneous in comparison to the pure silica. TEM and UV–Vis DRS techniques confirmed the structure and presence of the adsorbed proteins on MCF material.