From March 1, 1966 through March 31, 1967, 525 patients on the General Surgery Service of Brooke General Hospital underwent abdominal surgery during which the gastrointestinal or the biliary tracts were open. In three (1.5 per cent) of 189 patients who received prophylactically a combination of penicillin G, chloramphenicol, and methicillin before, during, and immediately after operation wound infections developed, whereas wound infections occurred in thirty-seven of 336 control patients. The difference in incidence of infection between these two groups of patients is highly significant (p < .001) and suggests that the prophylactic use of antibiotics in these patients reduced the incidence of wound infection. Specific groups of patients in whom the incidence of wound infections apparently was reduced significantly by prophylactic administration of antibiotics included those who underwent cholecystectomy, emergency gastric surgery for bleeding, elective gastric surgery, and emergency colostomies. In view of the high degree of statistical significance in the difference in incidence of wound infection in the totals of treated and control patients, the lack of statistically significant difference in incidence of wound infections between treated and control subgroups of patients undergoing other abdominal operations probably can be attributed to the small number of patients in these groups.
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