We report on the multi-year evolution of the population of X-ray sources in the nuclear region of NGC 3621 based on and observations. Among these, two sources, X1 and X5, after their first detection in 2008, seem to have faded below the detectability threshold, a most interesting fact as X1 is associated with the active galactic nucleus (AGN) of the galaxy. Two other sources, X3 and X6, are presented for the first time, the former showing a peculiar short-term variability in the latest available dataset, suggesting an egress from eclipse, and hence belonging to the handful of known eclipsing ultra-luminous X-ray sources. One source, X4, previously known for its heartbeat (i.e. a characteristic modulation in its signal with a period of $ h), shows a steady behaviour in the latest observation. Finally, the brightest X-ray source in NGC 3621, here labelled X2, shows steady levels of flux across all the available datasets, but a change in its spectral shape, reminiscent of the behaviours of Galactic disc-fed X-ray binaries.