Bright Future Research Articles

Fenamates: Forgotten treasure for cancer treatment and prevention: Mechanisms of action, structural modification, and bright future.

Fenamates as classical nonsteroidal anti-inflammatory agents are widely used for relieving pain. Preclinical studies and epidemiological data highlight their chemo-preventive and chemotherapeutic potential for cancer. However, comprehensive reviews of fenamates in cancer are limited. To accelerate the repurposing of fenamates, this review summarizes the results of fenamates alone or in combination with existing chemotherapeutic agents. This paper also explores targets of fenamates in cancer therapy, including COX, AKR family, AR, gap junction, FTO, TEAD, DHODH, TAS2R14, ion channels, and DNA. Besides, this paper discusses other mechanisms, such as regulating Wnt/β-catenin, TGF-β, p38 MAPK, and NF-κB pathway, and the regulation of the expressions of Sp, EGR-1, NAG-1, ATF-3, ErbB2, AR, as well as the modulation of the tumor immune microenvironment. Furthermore, this paper outlined the structural modifications of fenamates, highlighting their potential as promising leads for anticancer drugs.

Study of Human–Robot Interactions for Assistive Robots Using Machine Learning and Sensor Fusion Technologies

In recent decades, the potential of robots’ understanding, perception, learning, and action has been widely expanded due to the integration of artificial intelligence (AI) into almost every system. Cooperation between AI and human beings will be responsible for the bright future of AI technology. Moreover, for a perfect manually or automatically controlled machine or device, the device must perform together with a human through multiple levels of automation and assistance. Humans and robots cooperate or interact in various ways. With the enhancement of robot efficiencies, they can perform more work through an automatic method; therefore, we need to think about cooperation between humans and robots, the required software architectures, and information about the designs of user interfaces. This paper describes the most important strategies of human–robot interactions and the relationships between several control techniques and cooperation techniques using sensor fusion and machine learning (ML). Based on the behavior and thinking of humans, a human–robot interaction (HRI) framework is studied and explored in this article to make attractive, safe, and efficient systems. Additionally, research on intention recognition, compliance control, and perception of the environment by elderly assistive robots for the optimization of HRI is investigated in this paper. Furthermore, we describe the theory of HRI and explain the different kinds of interactions and required details for both humans and robots to perform different kinds of interactions, including the circumstances-based evaluation technique, which is the most important criterion for assistive robots.

Thermal process computing in nanofluid using dissipation and squeezing constraints

AbstractThe investigation of thermal mechanisms in traditional as well as advanced fluid phases grabbed huge attention of the engineers around the globe. These fluids have a bright future in numerous fields including but not restricted to chemical, applied thermal, and heat transfer applications. Therefore, the present analysis emphasized on the development and investigation of a new nanofluid model under physical constraints like viscous dissipation, squeezing, and nanoparticle concentration effects. The fourth‐order heat transfer model is formulated using new thermophysical properties of tetra nanofluids and similar transformative functions. Then, the model was analyzed numerically and a deep discussion of the results was provided. It is noticed that the motion reduced near the bottom wall rapidly when the tetra nanoparticles concentration is taken from to and inward the sheet movement enhanced it. The fluid motion can be augmented by accelerating the top sheet in an outward direction by keeping . Moreover, the shear drag increased in the range of to and the heat transfer rate enhanced from to and to when and increased.

Tris(triazolo)triazine‐Based Covalent Organic Frameworks for Efficiently Photocatalytic Hydrogen Peroxide Production

AbstractTwo‐dimensional covalent organic frameworks (2D‐COFs) have recently emerged as fascinating scaffolds for solar‐to‐chemical energy conversion because of their customizable structures and functionalities. Herein, two tris(triazolo)triazine‐based COF materials (namely COF‐JLU51 and COF‐JLU52) featuring large surface area, high crystallinity, excellent stability and photoelectric properties were designed and constructed for the first time. Remarkably, COF‐JLU51 gave an outstanding H2O2 production rate of over 4200 μmol g−1 h−1 with excellent reusability in pure water and O2 under one standard sun light, that higher than its isomorphic COF‐JLU52 and most of the reported metal‐free materials, owing to its superior generation, separation and transport of photogenerated carriers. Experimental and theoretical researches prove that the photocatalytic process undergoes a combination of indirect 2e− O2 reduction reaction (ORR) and 4e− H2O oxidation reaction (WOR). Specifically, an ultrahigh yield of 7624.7 μmol g−1 h−1 with apparent quantum yield of 18.2 % for COF‐JLU52 was achieved in a 1 : 1 ratio of benzyl alcohol and water system. This finding contributes novel, nitrogen‐rich and high‐quality tris(triazolo)triazine‐based COF materials, and also designate their bright future in photocatalytic solar transformations.

Tris(triazolo)triazine-Based Covalent Organic Frameworks for Efficiently Photocatalytic Hydrogen Peroxide Production.

Two-dimensional covalent organic frameworks (2D-COFs) have recently emerged as fascinating scaffolds for solar-to-chemical energy conversion because of their customizable structures and functionalities. Herein, two tris(triazolo)triazine-based COF materials (namely COF-JLU51 and COF-JLU52) featuring large surface area, high crystallinity, excellent stability and photoelectric properties were designed and constructed for the first time. Remarkably, COF-JLU51 gave an outstanding H2O2 production rate of over 4200 μmol g-1 h-1 with excellent reusability in pure water and O2 under one standard sun light, that higher than its isomorphic COF-JLU52 and most of the reported metal-free materials, owing to its superior generation, separation and transport of photogenerated carriers. Experimental and theoretical researches prove that the photocatalytic process undergoes a combination of indirect 2e- O2 reduction reaction (ORR) and 4e- H2O oxidation reaction (WOR). Specifically, an ultrahigh yield of 7624.7 μmol g-1 h-1 with apparent quantum yield of 18.2 % for COF-JLU52 was achieved in a 1 : 1 ratio of benzyl alcohol and water system. This finding contributes novel, nitrogen-rich and high-quality tris(triazolo)triazine-based COF materials, and also designate their bright future in photocatalytic solar transformations.

Membangun Budaya Kreatif Melalui Seni Batik di Yayasan Cinta Yatim & Dhuafa, Pisangan Barat, Kec.Cirendeu, Kota Tangerang Selatan

Abstract. Education plays an important role in shaping a bright and sustainable future, with creative and fun learning as the key to creating an inspiring learning environment. This article examines the event "SEBATIK - Batik Art for Creative Culture" held at the Yayasan Cinta Yatim dan Dhuafa, Cirendeu, South Tangerang on July 20, 2024. This event aims to introduce and preserve batik art, as well as to arouse interest and appreciation for traditional arts among the children of the foundation. With a creative and interactive approach, this workshop teaches basic batik techniques through training and direct practice, and provides appreciation to participants through prizes. The evaluation results show that this activity has succeeded in increasing the creativity and skills of children, as well as strengthening the relationship between the foundation and the community. This workshop also has the potential to open up new business opportunities for foster children, increasing their economic independence in the future. This article presents details of the event implementation, the results achieved, and its impact on participants and the foundation.

Assessing inequality of opportunities to child health and nutrition: comparison of Bangladesh and Pakistan

The bright future of any society is always associated with its upcoming generation. Children are the future prosperity of any nation as they are productive workers of tomorrow. The main objective of this study is to estimate the opportunities available for children under age of 5 years and their mothers for different regions of Pakistan and Bangladesh. The core idea of this study is to access and compare Pakistan with Bangladesh as it was previously a poor and struggling part of it. Data of this study are gathered from Bangladesh Demographic Health Survey and Pakistan Demographic Health Survey for the year 2017–18. The overall comparison of Pakistan and Bangladesh had put Pakistan in a situation where it lagged in every aspect of health-related facilities provided to its citizen. Governments should focus on providing economic opportunities, Health, education, and nutrition to enhance regional and area-level living standards. Further, rural areas should be more focused, especially by the Government of Pakistan.

Application of Odd-Order Derivatives in Fourier Transform Nuclear Magnetic Resonance Spectroscopy toward Quantitative Deconvolution.

When Fourier transform (FT) spectrum peaks are overlapped, primary maxima of odd-order derivatives can be used to evaluate their independent intensities. We studied the feasibility of higher odd-order derivatives on Lorentzian peak shape and magnitude peak shape. Simulation studies for FT nuclear magnetic resonance (NMR) spectroscopy demonstrated good results toward quantitative deconvolution of overlapping FT spectrum peaks. Although it is not so desirable to deconvolute special line shapes such as Gaussian, Voigt, and Tsallis profiles, the odd-order derivatives exhibit a bright future compared to even-order derivatives. An application example of practical NMR spectroscopy with ethylbenzene isomers is presented. White Gaussian noises were added to the simulated spectra at two different signal-to-noise ratios (20 and 40). Kauppinen's denoising and smoothing algorithms can effectively remove interference of the noise and help to have good deconvoluting results using the odd-order derivatives. We compared features of our approach with popular deconvolution sharpening algorithms and conducted a comparison study with Kauppinen's Fourier self-deconvolution. Our approach has a better dynamic range of peak intensities and is not sensitive to the sampling rates. Other common deconvolution methods are also discussed briefly.

Getting Everyone Jazzed about Electrochemistry: How Education in Electrochemistry Jump-Starts Citizen Science

As a science, electrochemistry (and methods therein) is one of the oldest methods of probing the world around us. Electrochemistry has witnessed tremendous growth in the past half-century. The science continues to be central to several areas of study, from materials science to biology to chemistry and beyond. Critical to the growth of electrochemistry as a field are robust pedagogical tools that introduce students to the joys of seeing the world through the goggles of an electrochemist. This talk will detail our group's strategy at developing pedagogical tools ranging from rather simple ways of building instrumentation to teaching our colleagues important historical insights. Electrochemistry must also be accessible to young students and senior citizens to cement its bright future as a foundational science, and we will discuss our activities to reach such groups to forge a foundation for citizen science.

Does working from home work? That depends on the home.

Working from home (WFH) has risen in popularity since the COVID-19 pandemic. There is an ongoing debate about the productivity implications of WFH, but the physical climate of the home office has received only limited attention. This paper investigates the effect of home office satisfaction and environment-improving behavior on productivity and burnout tendency for WFH employees. We surveyed over 1,000 Dutch WFH individuals about their home office and perceived WFH performance. We fit logistic regressions and structural equation models to investigate the effect of home office satisfaction and characteristics on self-reported productivity, burnout tendency, and willingness to continue WFH. Our results reveal that individual differences in WFH productivity are explained by heterogeneity in the physical home office environment. Higher satisfaction with home office factors is significantly associated with increased productivity and decreased burnout tendency. We continue by showing that more ventilation during working hours is associated with increased productivity, willingness to continue WFH, and burnout resilience. This effect is fully mediated by satisfaction with the home office. We find that higher home office satisfaction is associated with WFH success and air-quality-improving behavior is associated with higher satisfaction. Our results underline a holistic perspective such that investing in a healthy and objectively measured physical climate is a key aspect of the bright future of working from home. The move from the work office to the home office needs to be accompanied by careful design and investment in the quality of the office and its climate.

The Challenges of Conflict Transformation, Peacebuilding and Education Towards Intractable Conflicts: The Youth Involvement in North-Kivu Province, Democratic Republic of Congo

Peacebuilding and transformation are essential in creating a peaceful environment, in responding to conflicts and in promoting good relationships for social harmony. This paper establishes the challenges to transformation and peacebuilding in dealing with conflicts and violence among young people as it explores the strategies for conflict transformation and peacebuilding in North Kivu province. It looks at how these tools can help the youths and the communities to break away from violence and work towards peace. The study is based on the systems theory in general and confict transformation in particular how to train young generations to get out of conflicts and violence in order to preapre a bright future. Thus, the paper triangulates the systems theory, transformation, peacebuilding and the intergroup contact. From the participatory action research design, the paper provides resources in the struggle against intractable conflicts and subsequent violence for peacemaking. The paper establishes ubuntu as a starting point for conflict transformation, peacebuilding and in restoring peace and peaceful cohabitation among the youth in Eastern Democratic Republic of Congo.

A Bright Future: Dialectical Insights in Strategy-Making

A Bright Future: Dialectical Insights in Strategy-Making

A CLIIR Pathway to a Nursing Revolution.

The time for a nursing revolution is now. To ensure a bright future for generations, we must demonstrate by showing up with courage, letting go of our baggage as we know it, continuously inspiring others to join the movement, demonstrating an innovative spirit, and taking more risks to ensure a safe environment for all. [J Contin Educ Nurs. 2024;55(8):372-374.].

Effects of Antimicrobial photosensitizers of Photodynamic Therapy (PDT) to Treat Periodontitis.

Along with antimicrobial photosensitizers or antimicrobial photodynamic therapy (aPDT), Photodynamic therapy (PDT) is a therapeutic approach in which lasers and different photosensitizers (PSs) are used to eradicate periodontopathic bacteria in aggressive and chronic periodontitis. Periodontitis is a localized infectious disease caused by periodontopathic bacteria and can destroy bones and tissues surrounding and supporting the teeth. The aPDT system has been shown by in vitro studies to have high bactericidal efficacy. It was demonstrated that aPDT has low local toxicity, can speed up dental therapy, and is cost-effective. Several photosensitizers (PSs) are available for each type of light source which did not induce any damage to the patient and are safe. In recent years, significant advances have been made in aPDT as a non-invasive treatment method, especially in treating infections and cancers. Besides, aPDT can be perfectly combined with other treatments. Hence, this survey focused on the effectiveness and mechanism of aPDT of periodontitis by using lasers and the most frequently used antimicrobial PSs such as methylene blue (MB), toluidine blue ortho (TBO), indocyanine green (ICG), Malachite green (MG) (Triarylmethanes), Erythrosine Dyes (ERY) (Xanthenes dyes), Rose bengal (RB) (Xanthenes dyes), Eosin-Y (Xanthenes dyes), Radachlorin group and Curcumin. The aPDT with these PSs can reduce pathogenic bacterial loads in periodontitis. Therefore, it is clear that there is a bright future for using aPDT to fight microorganisms causing periodontitis.

Synthesis, characterization, and practical applications of perovskite quantum dots: recent update.

This review paper provides an in-depth analysis of Perovskite quantum dots (PQDs), a class of nanomaterials with unique optical and electronic properties that hold immense potential for various technological applications. The paper delves into the structural characteristics, synthesis methods, and characterization techniques of PQDs, highlighting their distinct advantages over other Quantum Dots (QDs). Various applications of PQDs in fields such as solar cells, LEDs, bioimaging, photocatalysis, and sensors are discussed, showcasing their versatility and promising capabilities. The ongoing advancements in PQD research and development point towards a bright future for these nanostructures in revolutionizing diverse industries and technologies.

The Heart and the Chip: Our Bright Future with RobotsThe Heart and the Chip: Our Bright Future with Robots Daniela Rus and Gregory Mone Norton, 2024. 272 pp.

The Heart and the Chip: Our Bright Future with RobotsThe Heart and the Chip: Our Bright Future with Robots Daniela Rus and Gregory Mone Norton, 2024. 272 pp.

From Dim Past to Bright Future

From Dim Past to Bright Future

Nucleic acid cancer vaccines targeting tumor related angiogenesis. Could mRNA vaccines constitute a game changer?

Tumor related angiogenesis is an attractive target in cancer therapeutic research due to its crucial role in tumor growth, invasion, and metastasis. Different agents were developed aiming to inhibit this process; however they had limited success. Cancer vaccines could be a promising tool in anti-cancer/anti-angiogenic therapy. Cancer vaccines aim to initiate an immune response against cancer cells upon presentation of tumor antigens which hopefully will result in the eradication of disease and prevention of its recurrence by inducing an efficient and long-lasting immune response. Different vaccine constructs have been developed to achieve this and they could include either protein-based or nucleic acid-based vaccines. Nucleic acid vaccines are simple and relatively easy to produce, with high efficiency and safety, thus prompting a high interest in the field. Different DNA vaccines have been developed to target crucial regulators of tumor angiogenesis. Most of them were successful in pre-clinical studies, mostly when used in combination with other therapeutics, but had limited success in the clinic. Apparently, different tumor evasion mechanisms and reduced immunogenicity still limit the potential of these vaccines and there is plenty of room for improvement. Nowadays, mRNA cancer vaccines are making remarkable progress due to improvements in the manufacturing technology and represent a powerful potential alternative. Apart from their efficiency, mRNA vaccines are simple and cheap to produce, can encompass multiple targets simultaneously, and can be quickly transferred from bench to bedside. mRNA vaccines have already accomplished amazing results in cancer clinical trials, thus ensuring a bright future in the field, although no anti-angiogenic mRNA vaccines have been described yet. This review aims to describe recent advances in anti-angiogenic DNA vaccine therapy and to provide perspectives for use of revolutionary approaches such are mRNA vaccines for anti-angiogenic treatments.

A meta-analysis of the meat physicochemical parameters of broiler chickens fed insect-based diet.

A total of 23 studies were identified in a literature search performed in the Scopus, Science Direct and Google Scholar databases for meta-analysis. The criteria used include studies that were published from 2015 to 2023 and those reporting the effects of insect meal utilisation in poultry diets. Data on live weight (LW), carcass weight (CW), moisture, meat pH, lightness (L*), redness (a*), yellowness (b*), proximate composition (protein, fat and ash content) and shear force in broilers were subjected to OpenMEE software, and data were pooled using a random-effect model. Subgroup analysis and meta-regression were performed to ascertain the influence of dietary insect meals on the response of meat aspects and the source of heterogeneity, respectively, using the following moderators (insect species, dosage level, feeding duration and age at slaughter). The results indicated that dietary insect meal did not affect LW, CW, meat L*, pH, shear force, moisture, fat and ash content. In contrast, dietary insect meal increased the a* of the meat (standardised mean differences (SMDs) = 1.03; 95% confidence intervals (CIs) = 0.484-1.578; p ≤ 0.001), b* (SMD = 1.117; 95% CI = 0.334-1.90; p = 0.005), and meat protein content (SMD = 0.365; 95% CI = 0.031-0.7; p = 0.032). The subgroup analysis showed that insect meal dosage of ≤10% and age at slaughtered ≤35 days had improved the LW, CW and meat L*. In addition, the meat a*, protein and ash content were also influenced by insect species, dosage levels and age at slaughter. In conclusion, ≤10% of either Hermetia illucens or Tenebrio molitor can be included in broiler diets without compromising the LW, CW, meat pH, colour, shear force, moisture, fat and ash content in broilers. The study therefore indicated that insect meals have a bright future as an alternative protein source in poultry diets.

Exploring the New Interpretation of the Fengshen Story

As a classic Chinese mythology novel, Fengshen yanyi (Investiture of the Gods) is famous for its cultural value, historical value and social value. The story of “Fengshen” is also considered a rich source of inspiration for entertainment and cultural industries in China, influencing a wide range of audiences with diverse backgrounds. As developing the potential “story universe” of Fengshen has become a hot topic in the Chinese film market, reinterpreting Chinese mythology needs to be focused on. Based on the case of the “Fengshen story”, this study aims to explore the new context of Chinese mythology by collecting and analyzing secondary research, categorizing and organizing the findings, and discussing further research from different perspectives, thereby understanding the modern adaptations of traditional Chinese mythology and suggesting a bright future of conducting interdisciplinary research on Chinese mythology in the new context.