Relevance. This article shows the research conducted by researchers from the agrotechnical department of the Bykovskaya melon breeding station from 2018 to 2020.Results. The data obtained make it possible to scientifically substantiate the most cost-effective methods and techniques for treating table watermelon plants to increase productivity in the Volgograd Trans-Volga region. Indicators of economic efficiency of production make it possible to compare the results of economic activity and reveal the productivity of the enterprise for this period in connection with an increase in the use of means of production and labor. In modern conditions of development of agricultural production, there is a need to develop new technologies adapted to the new conditions of land use. In connection with the sharp decline in recent years in the use of fertilizers, the problem arose of finding ways to maximize the use of the biological factor. To obtain stable yields, it is necessary to increase the adaptive capabilities of plants to extreme conditions in which gourds are grown in the zone of industrial melon growing in the Volgograd Trans-Volga region. One of them is the use of plant growth regulators and water-soluble fertilizers. One of the advantages of these drugs is their simplicity, variety of methods of their application and low cost. According to the cost-effectiveness data, it can be seen that the foliar treatment of table watermelon plants was the best option. In the first experiment, the Fitozont regulator, in the second, the water-soluble fertilizer Khakafos with one and a half norm (0.9), in the third experiment, the best results were shown by the variant with foliar treatment with a growth regulator in combination with the water-soluble fertilizer Vigor Forte + Agrovin Profi at a dosage of (0.05+0.5).