Breakthrough Innovation Research Articles

Lipid matrix-specific pretreatment method for enhancing the extractability and allergenicity maintenance of bovine milk allergens in ELISA detection

The presence of various components in the food matrix makes allergen detection difficult and inaccurate, and pretreatment is an innovative breakthrough point. Food matrices were categorised based on their composition. Subsequently, a pretreatment method was established using a combination of ultrasound-assisted n-hexane degreasing and weakly alkaline extraction systems to enhance the detection accuracy of bovine milk allergens. Results showed that more allergens were obtained with less structural destruction, as demonstrated using immunological quantification and spectral analysis. Concurrently, allergenicity preservation was confirmed through liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis, a KU812 cell degranulation model, and western blotting. The method exhibited good accuracy (bias, 8.47%), repeatability (RSDr, 1.52%), and stability (RSDR, 5.65%). In foods with high lipid content, such as chocolate, the allergen content was 2.29-fold higher than that of commercial kits. Laser confocal scanning microscopy (LCSM) and scanning electron microscopy (SEM) analyses revealed a significant decrease in fat content after post-pretreatment using our method. In addition, colloidal stability surpassed that achieved using commercial kits, as indicated through the PSA and zeta potential results. The results demonstrated the superiority of the extractability and allergenicity maintenance of lipid matrix-specific pretreatment methods for improving the accuracy of ELISA based allergen detection in real food.

First row transition metal catalyzed small molecule activation for sustainable organic transformation: Synergy between nature and chemist’s toolbox

In this review we have tried to present our view on the synergy between nature and chemists’ toolbox toward discovery of new reactions. Toward the search for new chemical reactivity, not only chemists learn from nature but nature’s evolutionary pathway perhaps has footprints of chemist’s innovative discoveries and beyond. Taking CO2 as a representative example of an abundant energy rich small molecule resource, we have tried to explore the probable strategies of activating the molecule using first row transition metal catalysts for sustainable organic transformation. Our study has tried to unfold nature’s strategy of CO2 activation and recycling which eventually motivated chemists toward discovery of new chemical reactions and further inspired to expand their toolbox for discovering new reactivities beyond the natural enzyme repertoire. The basic chemical CO2 activation strategy which have been focused in this review are using CO2 as a C1 building block in organic synthesis; catalytic reductive formylation and methylation of amines; carboxylation reactions via CO2 insertion. Additionally, carbonylation reactions with CO2 as CO surrogate has also been discussed. The focus of this review is to correlate nature’s chemical strategies with chemist’s approach to understand the concept involved in the chemical activation and utilization process of CO2 for unlocking new reaction paradigm, both for chemists’ and for nature’s catalytic repertoire.

Sulfur vacancies and heterogeneous interfaces promote high performance sodium storage of bimetallic chalcogenide hollow nanospheres

Transition metal sulfides have high theoretical capacities and are considered as potential anode materials for sodium-ion batteries. However, due to low inherent conductivity and significant volume expansion, the electrochemical performance is greatly limited. In this study, a nickel/manganese sulfide material (Ni0.96Sx/MnSy-NC) with adjustable sulfur vacancies and heterogeneous hollow spheres was prepared using a simple method. The introduction of a concentration-adjustable sulfur vacancy enables the generation of a heterogeneous interface between bimetallic sulfide and sulfur vacancies. This interface collectively creates an internal electric field, improving the mobility of electrons and ions, increasing the number of electrochemically active sites, and further optimizing the performance of Na+ storage. The direction of electron flow is confirmed by Density functional theory (DFT) calculations. The hollow nano-spherical material provides a buffer for expansion, facilitating rapid transfer kinetics. Our innovative discovery involves the interaction between the ether-based electrolyte and copper foil, leading to the formation of Cu9S5, which grafts the active material and copper current collector, reinforcing mechanical supporting. This results in a new heterostructure of Cu9S5 with Ni0.96Sx/MnSy, contributing to the stabilization of structural integrity for long-cycle performance. Therefore, Ni0.96Sx/MnSy-NC exhibits excellent electrochemical properties following our modification route. Regarding stability performance, Ni0.96Sx/MnSy-NC demonstrates an average decay rate of 0.00944% after 10,000 cycles at an extremely high current density of 10000 mA g−1. A full cell with a high capacity of 304.2 mA h g−1 was also successfully assembled by using Na3V2(PO4)3/C as the cathode. This study explores a novel strategy for interface/vacancy co-modification in the fabrication of high-performance sodium-ion batteries electrode.

The role of digital platforms in the economic crisis management

The need for urgent mitigation of the consequences of dramatic emergency situations has been predominating in recent years. In response to unpredictable disasters organizations all over the world started to apply a number of breakthrough technologies by means of confusing response strategies. Publications lack appropriate information on the most effective methods of recovering from the economic crisis, so the decisions are chosen among new breakthrough technologies in the digital platforms systems. To complete the gap in the literature the article applies to the studying of the theory of economic crisis. The purpose of the article is to create a theoretical model based on the most effective breakthrough innovations in the digital platforms mechanisms through the lens of the analysis of the adaptive management model.

Exploring and evaluating the index for interdisciplinary breakthrough innovation detection

PurposeThis study aims to establish a reliable index to identify interdisciplinary breakthrough innovation effectively. We constructed a new index, the DDiv index, for this purpose.Design/methodology/approachThe DDiv index incorporates the degree of interdisciplinarity in the breakthrough index. To validate the index, a data set combining the publication records and citations of Nobel Prize laureates was divided into experimental and control groups. The validation methods included sensitivity analysis, correlation analysis and effectiveness analysis.FindingsThe sensitivity analysis demonstrated the DDiv index’s ability to differentiate interdisciplinary breakthrough papers from various categories of papers. This index not only retains the strengths of the existing index in identifying breakthrough innovation but also captures interdisciplinary characteristics. The correlation analysis revealed a significant correlation (correlation coefficient = 0.555) between the interdisciplinary attributes of scientific research and the occurrence of breakthrough innovation. The effectiveness analysis showed that the DDiv index reached the highest prediction accuracy of 0.8. Furthermore, the DDiv index outperforms the traditional DI index in terms of accuracy when it comes to identifying interdisciplinary breakthrough innovation.Originality/valueThis study proposed a practical and effective index that combines interdisciplinary and disruptive dimensions for detecting interdisciplinary breakthrough innovation. The identification and measurement of interdisciplinary breakthrough innovation play a crucial role in facilitating the integration of multidisciplinary knowledge, thereby accelerating the scientific breakthrough process.

Nanoplasmonic Affinity Analysis System for Molecular Screening Based on Bright‐Field Imaging

AbstractConsidering the improved detection of biological analytes for affinity analysis is highly desirable, a metasurface plasmon resonance (Meta‐SPR)‐based imaging system, incorporating a localized SPR sensing platform with different microfluidic systems and employing simple bright‐field imaging, is established in this study. This system enables low‐level analyte concentration analysis, ranging from 100 pm to 100 nm, with the real‐time removal of nonspecific binding signals within the same device field of view. Combined with microfluidic systems and microdroplet spotting, it is possible to automatically measure the kinetic curves of a sample at ten concentration gradients or detect the specific responses of multiple samples in a single experiment simultaneously. This system can inexpensively and conveniently achieve complex detection functions, demonstrating an innovative breakthrough in sensor detection.

The increasing costs of medicines and their implications for patients, physicians and the health system.

Most new medicines entering the market are high-cost speciality drugs. These drugs can cost tens to hundreds of thousands of dollars per course of treatment and in some cases millions of dollars per dose. Approximately half of all spending on medicines is projected to target only 2-3% of patients, raising important questions about resource allocation. While there is no doubt that breakthrough innovations have transformed clinical care in some disciplines, it is also true that cost is becoming one of the primary barriers to treatment access and that many new medicines do not provide value commensurate with their prices. This article examines pricing trends, the reasons for high prices and their implications for access and clinical practice.

Digital transformation's impact on innovation in private enterprises: Evidence from China

In the digital economy era, the pathways of digital transformation and intelligent development have emerged as crucial avenues for enterprises’ high-quality development. Focusing on listed private enterprises from 2011 to 2020, this study uses text mining to extract keywords related to digital transformation, as disclosed in annual reports. We construct a digital transformation index and empirically examine its impact on enterprise innovation and innovation incentive policies’ synergistic effects. The results demonstrate that digital transformation significantly promotes innovation in private enterprises, with a more pronounced catalytic effect in economically developed regions characterised by higher levels of the digital economy and larger enterprises. Simultaneously, innovation incentive policies play a crucial role in enhancing digital transformation's impact on innovation in private enterprises. Further investigation reveals that digital transformation's impact mechanism on private enterprise innovation is driven primarily by four paths—specifically improving information transparency, reducing operational risks, alleviating financing constraints, and enhancing total factor productivity. This study provides empirical evidence regarding innovation breakthroughs and driving paths for private enterprises to achieve high-quality development as well as valuable references and insights for policy formulation.

The Influence of CG Technology on The Aesthetics of Chinese Magic Films Take The Candle in The Tomb Film Series for Example

This study aims to investigate the impact of computer-generated imagery (CG) on the aesthetic context and innovation of oriental gods and creatures in Chinese magical film footage. This study focuses on the analysis and research of CG technology in Chinese magical film lens images, as well as the aesthetic habits and aesthetic psychology of contemporary audiences towards oriental gods and creatures. This research employs a qualitative research approach because it is appropriate for examining the cultural background and aesthetic habits of Chinese magical film lens images created using CG technology, as well as the aesthetic emotions that the film evokes in its audience. This study specifically examines the aesthetic expression and breakthrough innovation of oriental gods and monsters in the CG screen effects of the film series Candle In The Tomb, as well as the operation process of Chinese magical film CG technology and its expression based on and the generative context and breakthrough innovation of oriental gods' aesthetic style. This study will provide a theory of the CG technology used to guide the visual aesthetics of Chinese fantasy films. It will benefit creators of Chinese magic films, researchers, academicians, students, and those interested in the subject's study and preservation.

RESEARCH ON THE RELATIONSHIP BETWEEN ACTIVE ORGANIZATIONAL FORGETTING AND AMBIDEXTROUS INNOVATION OF HIGH-TECH ENTERPRISES

From the perspective of boundary-spanning research, this paper intends to analyze the influence mechanism of active organizational forgetting on the ambidextrous innovation of high and New-tech enterprises, and explore how high and new-tech enterprises and of the heterogeneity of knowledge acquired from outside to make up for the deficiency of make up for the deficiency of their own knowledge in key core fields, optimize the traditional organizational structure, and enrich the internal knowledge stock under the trans-boundary search of technology and market. This study proposes that absorption capacity as moderating variable has a positive moderating effect on boundary spanning search and firm ambidextrous innovation. This is because knowledge acquired from inside and apply it, realize breakthrough innovation and form core competitive advantages, so as to help the enterprise realize so as to help the enterprise realize ambidextrous innovation. It is of great theoretical value to further deepen and perfect the interaction mechanism between knowledge management and innovation management theory.

Unveiling the transtensional geodynamics of Cenozoic depocenter changes in the Andaman sea: Seismic evidence for the existence of the East Sagaing Fault and the Andaman Basin Central Fault Zone in the Tanintharyi region

The Andaman Sea, situated at the highly oblique convergent boundary of the Indian and the Sunda Plates in the eastern Indian Ocean, has been shaped by transtensional geodynamics throughout the Cenozoic and has given rise to the formation of fault systems in the Andaman back-arc region. Out of these faults, the Sagaing Fault system exists as the active transform boundary between the Burmese and Eurasian Plates. The East Sagaing Fault, which runs through the Gulf of Martaban in the Andaman Sea, is a critical component of this Sagaing Fault system in fostering the transtensional regime and contributing to the opening of the Andaman Sea as a pull-apart basin. In contrast, the Andaman Basin Central Fault Zone, previously misinterpreted as the South Sagaing Fault, is an inactive fault system that experienced deformation until the Middle Miocene and is currently concealed beneath the East Andaman Basin. This temporal disparity in the Andaman Basin Central Fault Zone and East Sagaing Fault activity patterns has led to uncertainty regarding their existence within the Tanintharyi region of the Andaman Sea. To address this uncertainty, 2D and 3D seismic data interpretations were used to explore the distribution of faults, including the presence and extent of these two faults in the Tanintharyi region. Through a comparative analysis of the structural characteristics of the East Sagaing Fault in the northern part, and the Andaman Basin Central Fault Zone in the southern part of the Andaman Sea, this study presents compelling evidence confirming the existence of both faults in the Tanintharyi region with their structural implications. The innovative discoveries in this article contribute to a deeper understanding of Cenozoic depocenter changes in the Tanintharyi region, substantiating the significance of these two faults in transtensional geodynamics and allowing for a comprehensive examination of geodynamic evolution in the Andaman Sea region.

Cross-industry vs. same-industry acquisitions: unveiling their differential impacts on innovation in the smartphone industry

ABSTRACT Firm acquisitions have emerged as a pivotal driver of innovation, particularly in the smartphone industry. This study investigates the effects of different acquisition strategies – same-industry and cross-industry – on innovation. By analysing data from 84 acquisitions by smartphone firms between 2007 and 2022, along with United States Patent and Trademark Office (USPTO) patent records, it is evident that cross-industry acquisitions significantly enhance innovation. By contrast, same-industry acquisitions do not impact firm innovation. This trend is also consistent with breakthrough innovations examined through patent citations. The findings underscore the crucial role of cross-industry acquisitions in stimulating substantial innovation and provide key insights for strategic economic decision-making, particularly for firms that consider diverse acquisition strategies.

Historic corn yield, production, and economic value trends in Kansas

AbstractWorld corn (Zea mays L.) production has tripled since the 1960s. However, without new breakthrough innovations the trend is expected to plateau or decrease in the future. The objective of this study was to quantify Kansas corn production, economic value, productivity, annual production variation, yield gap trends, and in due course, identify future areas for research. Corn variety performance tests and United States Department of Agriculture (USDA) data were used for this study. Results showed that the area planted to corn in Kansas increased from 0.5 million in 1880s to over 2 million ha by 2022, with an increase of 0.05 million ha year−1 between 1984 and 2022. The value of corn produced in Kansas also increased significantly from below $1 billion annually prior to 1990s to the current value of approximately $3–$4 billion. The average corn yield gain from 1972 to 2000 was 132 kg ha−1 year−1, which declined to 12 kg ha−1 year−1 during 2000 to the early 2020s. Also, a relatively high yield variability occurred from 1970 to the early 2020s compared with earlier years (1866–1970), and a 42%–68% gap between the potential and actual corn yields was identified. We concluded that there is a decrease in the rate of corn yield increase and developing farmer awareness and their adoption of new corn production technology, increasing longevity of the Ogallala Aquifer, and integrated research should be priorities to avert the decreasing trend of corn productivity and further increase corn economic value.

Highly sensitive detection of the neurodegenerative biomarker Tau by using the concentration effect of the pyro-electrohydrodynamic jetting

It is largely documented that neurodegenerative diseases can be effectively treated only if early diagnosed. In this context, the structural changes of some biomolecules such as Tau, seem to play a key role in neurodegeneration mechanism becoming eligible targets for an early diagnosis. Post-translational modifications are responsible to drive the Tau protein towards a transition phase from a native disorder conformation into a preaggregation state, which then straight recruits the final fibrillization process. Here, we show for the first time the detection of pre-aggregated Tau in artificial urine at femto-molar level, through the concentration effect of the pyro-electrohydrodynamic jet (p-jet) technique. An excellent linear calibration curve is demonstrated at the femto-molar level with a limit of detection (LOD) of 130 fM. Moreover, for the first time we show here the structure stability of the protein after p-jet application through a deep spectroscopic investigation. Thanks to the small volumes required and the relatively compact and cost-effective characteristics, this technique represents an innovative breakthrough in monitoring the early stage associated to neurodegeneration syndromes in different scenarios of point of care (POC) and such as for example in long-term human space exploration missions.

Collaborative Governance and the Urgency of Digitizing Public Services: Encouraging Licensing and Legalization of Local Businesses

This study aims to analyze licensing and local business legalization, collaborative governance, and simultaneous digitization of public services. This study takes a case study in Barru District, South Sulawesi. The reason for choosing this case study is because Barru Regency is one of the regencies that has implemented breakthrough innovations in the field of business licensing and has been recognized nationally. This research uses a qualitative approach by relying on online research methods (ORMs) to collect data and information through official government websites. The analysis tool used is Nvivo 12 Plus for data coding. The findings of this study indicate that the Government of Barru District has adopted the concept of collaborative governance and digitization of public services to encourage licensing and legalization of local businesses. It involves the involvement of local governments, the private sector and the general public in a more transparent, accountable and efficient licensing process and business management. The government has also explicitly set up a licensing agency to personally visit business actors. In addition, the government also initiated website-based digital services. The government's official website in Barru District has positively contributed to providing easy and fast access to public services, such as information on business licensing applications, investment opportunities, service standards, and sectoral data mapping. Complaint services and call centres are also available to assist the community in providing input and complaints related to public services regarding licensing and legalization of local businesses.

Research of the mechanism of innovation implementation in the activities of Russian enterprises

In the conditions of globalization and development of information technologies, the competition of enterprises on national and international scales is significantly aggravated, which determines the importance of ensuring competitive advantages for any enterprise through innovation. In modern conditions, the effectiveness of innovation activity of the enterprise and, accordingly, its competitiveness depends primarily on the completeness and reliability of business information about the activities of counterparties and the conditions of the external environment. The value of informing about possible changes in the business environment has a manifestation through the prevention of tactical and strategic errors of enterprise management. Innovative development is the basis of competitiveness of modern economies, which provides the possibility of accelerated growth at macro- and micro-levels on the basis of creation and strengthening of intellectual potential in the global business environment. Despite the presence of significant conditions for qualitative changes on an innovative basis, the Russian Federation continues to be in a complex highly turbulent period of unstable growth. Therefore, the task of domestic economic science is to find mechanisms for the implementation of modern management of innovative development in the practice of enterprises in the Russian Federation, systematizing and developing its methodology. This requires an in-depth scientific study in the direction of searching for conceptual foundations for the activation of innovative development of enterprises to make a technological leap in the Russian Federation, in particular, on the basis of attracting breakthrough innovations, modern concepts of knowledge management, formation of relevant business models, management of high added value processes and the use of information and communication technologies in the digital space.

A SCALE UP FOR LOCAL PRODUCT THROUGH SACRIFICING THE HIGH-QUALITY BY TECHNO-PRENEURSHIP: CASE STUDY SADE VILLAGE, LOMBOK ISLAND

Purpose: This research paper aims to develop a vision statement for breakthrough innovations in the notation and recording industry, enhancing revenue generation and profitability, addressing customer needs, aligning local business teams, and stimulating economic growth.
 
 Methods: This research paper uses a combination of qualitative research and stra-tegic business development methods to develop a vision statement and strategies for the notation and recording industry. It focuses on understanding stakeholders' needs, identifying innovation opportunities, and implementing strategies in real-world settings to drive sustainable growth.
 
 Results and Conclusion: The research reveals that a vision statement and stra-tegic business development initiatives have significantly increased revenue and profitability in the notation and recording industry. These strategies have fos-tered confidence in regulatory compliance, customer satisfaction, and business team alignment. They have also facilitated economic growth and community empowerment, particularly in regions like Lombok Island.
 
 Research implications: The research emphasizes the importance of continuous innovation, regulatory compliance, customer-centricity, community engagement, strategic alignment, and continuous adaptation in the notation and recording in-dustry. These factors help businesses stay competitive, maintain trust, and contrib-ute to sustainable growth. By fostering a culture of collaboration and continuous monitoring, businesses can enhance their performance and drive sustainable devel-opment.
 
 Originality/value: This research presents a comprehensive approach to developing a vision statement and implementing strategic initiatives in the notation and re-cording industry. It emphasizes innovation, simplicity, and speed, integrates quali-tative research with business strategy, emphasizes responsible practices, strategic alignment, and relevance to emerging markets. The research provides insights to help practitioners navigate complex challenges and unlock new opportunities.

ФОРМУВАННЯ СИСТЕМИ КОНСУЛЬТАЦІЙНОГО СУПРОВОДУ ІННОВАЦІЙНОГО РОЗВИТКУ СІЛЬСЬКОГОСПОДАРСЬКИХ ПІДПРИЄМСТВ — СОЦІОЛОГІЯ ПРОБЛЕМИ

Innovation is one of the most important forms of expanding the economic system's capabilities and competitiveness in a modern, dynamic world. Since the beginning of the 20th century, the theory of innovation has been developing, changing, and improving significantly and many scientific papers have been created on the topic of types of innovation. However, even today, scientists are confused in basic concepts, replacing one with another and taking one for the other without proper and in-depth terminology understanding. Although from innovation direction point of view, there is a clear distinction between types, some uncertainty in the levels (degrees) of innovations is present. For many years there have been many differences in the scientific literature, which significantly influenced both the in-depth understanding of the innovation concept and the quality of approaches to assessing the levels of innovation. The purpose of this paper is to in-depth review the literature on innovation types to identify approaches that emphasize the degree of innovation. We considered the different conclusions of the researchers step by step and argue that there is the problem of identifying one or another innovation in terms of its degree and find the disagreements in the scientific literature in basic concepts to understand high degree innovation. The most complete and extended definitions of incremental, semi-radical, radical, disruptive, and breakthrough innovation were proposed as well as Degree of Innovation matrix was created to clearly demonstrate the existing distinctive features of each individual degree of innovation. This paper contributes to the theoretical analysis of the impact of innovative knowledge, as well as broadens previously published scientific literature, analyzing its impact on understanding the types and degrees of innovation, as well as the relationships, characteristics and key differences between them. The results of the research is the conceptual basis supported by the scientific literature for the modern understanding of terminology in the field of innovation activities.

The Transformative Trajectory of Artificial Intelligence in Education: The Two Decades of Bibliometric Retrospect

Integrating artificial intelligence (AI) stands out as the most dynamic and innovative breakthrough in introducing disruptive paths in the varied domains of education. This bibliometric analysis delved into the trajectory of AI’s evolving landscape within educational settings over two decades, encompassing 324 articles published from 2003 to 2023, sourced from the Scopus database. The study uncovers a substantial surge in publications with a steep increase from 2020, peaking in 2023. Notably, while established nations like China and the US lead in publications, notable contributions from other developing countries, including Saudi Arabia, India, and Malaysia, underscored a global shift. Key terms, including students, machine learning, AI and higher education, underpin the central focus research areas while emerging themes like “generative AI” and chatbots like “chatgpt” mark the evolving trends. Further, the study prompts sustained global partnerships, interdisciplinary collaborations, and continued exploration of emerging AI technologies to catalyze educational advancements.

RUSSIA IN THE 2020S: INDUSTRY 4.0 AND SOCIO-POLITICAL ASPECTS OF ITS INTEGRATION IN MASS ESTIMATES OF THE POPULATION (BASED ON SOCIOLOGICAL RESEARCH)

Purpose of the study: to form an objective understanding of the socio-political issues of integrating Industry 4.0 technologies into modern society in general and Russian society in particular. Methodology. The author, using a wide range of the latest domestic and foreign sources, conducts a consistent analysis of the most general issues related to the topic of the work, gives a general description of the theoretical discourse on the integration of Industry 4.0 technologies into society, and considers the interpretation of socio-political aspects in a (joint) “smart” production of Industry 4.0, explores pressing problems with compliance with established socio-economic practices in joint intelligent production, explores the presence of “fear of the future” in society, attitude towards breakthrough innovations of Industry 4.0, using the example of a survey of European society, the attitude of Russian society to the perception of Innovation 4.0 is outlined. Conclusions. Based on the results of the analysis, the author comes to the logical conclusion that the traditional system of established socio-economic practices will undoubtedly face a whole range of new challenges that may lead to a change in views on its form and content, both theoretical and theoretical. and applied it. in terms of compliance and execution of the plan. Especially, according to the author, this can be clearly manifested in the corporate sphere, which in the foreseeable future will become increasingly complex, and in the judicial sphere, where it will be unclear who to file claims against as a result of a trial for restoration or compensation for harm based on the results of an established violation of civil law.