A performance analysis of a multi-stage safety injection tank (MSIT) was carried out using a numerical method. A MSIT is capable of injecting coolant from a single tank in multiple stages in the event of a loss of coolant accident (LOCA) at a nuclear power plant. The performance and consequences of two- and three-stage MSITs were compared. The effects of break size, installation heights of the injection lines, and pressure-loss coefficients of each injection line were scrutinized. By selecting pertinent design parameters, the MSIT can satisfy its design requirements, by providing continuous coolant injection without problems of delays or overlaps for a minimum of 72 h after a LOCA.