The high cost of branded name pharmaceuticals in the nutraceuticals sector is a problem in Asian countries such as Singapore, Malaysia, and Cambodia. Generic medications, which are less expensive and more competitive than branded drugs, play an important role in boosting drug access and lowering drug costs. The pharmaceutical market in Southeast Asia is rapidly expanding. There are ten countries in the Asian region. All countries have a comparable regulatory environment. However, the registration requirements and procedures differ from country to country throughout the Asian region. Despite the fact that ACTD is harmonized for all ten nations, various local criteria, such as administrative, technical, clinical, and non-clinical papers, GMP, and ICH standards vary by country. This review article will provide an overview of the drug registration regulations of nutraceuticals in three key player ASEAN member states such as Singapore, Malaysia & Cambodia.