Pharmaceutical Evaluation of Acetaminophen Tablets Marketed in Duhok City-kurdistan

Abstract

Tablets are the most frequently administered oral solid dosage form. The presence of various brands at varying costs from different companies requires verification to see whether they pass control tests and to determine which one is more effective and economical. Eight different brands were chosen, and their weight uniformity, hardness, friability, disintegration time, and drug content were tested. Then, prices were compared to quality to determine which brand was more effective and economical. All brands selected pass the United States Pharmacopeia (USP) tests for weight variation, friability, and disintegration time. Maximum weight variation was expressed by brand C, whereas brand A expressed the minimum. Brand E has the highest friability, while brand D has the lowest. The maximum disintegration time expressed is by brands E and G, while the minimum is expressed by brands B, D, F, and H. All the selected brands have enough hardness to withstand handling and manufacturing processes, except brand A, C, and G shows hardness somewhat outside the acceptable range, but this did not affect their disintegration time. According to USP, only two brands (A and H) pass the drug content test, with brand H having the maximum drug content and brand E the minimum. A and H were determined to be the most cost-effective brands based on a correlation between quality and prices