Introduction: The expanding need for fossil fuels emphasizes the necessity to comprehend renewable energy sources. Methods: This study examined the performance of a single-cylinder diesel engine using Jatropha biodiesel and aluminum dioxide—the research aimed to evaluate engine reactivity to compression ratio and load variations. The experiment employed with varitaion compression ratios. Results: This study used the Response Surface Methodology to find the best Brake Specific Fuel Consumption performance indicator location. The researchers used a Central Composite Design setup for analysis. A regression model employing the response surface approach was then created to predict fuel phase-out likelihood. Conclusion: This study examines multiple factors' effects. According to studies, Jatropha biodiesel and its blends may improve engine efficiency and lower brake-specific fuel consumption compared to diesel fuel. Minor input parameter modifications are needed to gain these benefits.