A case report on enhancing self-regulation skills through QEEG-guided neurofeedback was conducted for a subject who has been diagnosed with Wilson Disease (WD). The trauma-informed neurofeedback training protocols were developed to improve the client’s self-regulation skills in order to address his psychological symptoms and cognitive impairment. The protocols were developed based on the findings of the prior empirical research as well as the QEEG brain mapping assessment of the client. In this case report, the utilisation of expressive art therapy application was highlighted in facilitating the therapeutic process for the clients having difficulty in verbal communication. The QEEG brain mapping assessment result pre-and-post intervention were compared to determine the progress of the client’s brainwave activity pattern. Meanwhile, the self-report diary of the client’s parent was used to follow up his conditions. The outcome indicated that the developed protocols of trauma-informed neurofeedback training and expressive art application were helpful in improving the self-regulation skills of the client.