Objective To investigate the effects of full process comprehensive nursing on the transport of emergent and brain trauma patients. Methods A total of 100 brain trauma patients in Emergency Department accepted retrospective analysis, in which 50 patients received routine transport nursing from June 2012 to May 2013 in our hospital as control group while 50 cases accepted full process comprehensive nursing intervention from June 2013 to May 2014 as observation group. We compared the transit time, check the waiting time, transport rates of adverse events and receiving departments′ satisfaction between the two groups. Results The incidence rate of adverse transfer event was 4% in the observation group, which was significantly lower than that in the control group (16%) (χ2=4.000, P<0.05). The transit time, check the waiting time in the observation group were (10.54±4.47) min and (0.44±0.19) min, which were lower than these of the control group [(16.43±5.21)min and (1.57±0.26)min], (t=6.067, 24.813; P<0.05); the receiving transport departments′ satisfaction rate of observation group was 96%, significantly higher than that in the control group which was 84% (χ2=4.000, P<0.05). Conclusions For emergency brain trauma patients, full process comprehensive nursing intervention can reduce the time of transiting and waiting for check. It also can reduce the occurrence of adverse events in hospital transport and improve receiving departments′ satisfaction, so it is worthy of clinical attention. Key words: Full process comprehensive nursing; Emergency Department; Brain trauma; Hospital transport