You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Evaluation1 Apr 20111316 HYPOGONADISM, BONE MINERAL COMPOSITION AND LIPID ABNORMALITIES IN ADULT MALE PATIENTS WITH SICKLE CELL DISEASE Belinda Morrison, Suzanne Soares-Wynter, Wendy Madden, and Marvin Reid Belinda MorrisonBelinda Morrison Kingston 6, Jamaica More articles by this author , Suzanne Soares-WynterSuzanne Soares-Wynter Kingston 6, Jamaica More articles by this author , Wendy MaddenWendy Madden Kingston 6, Jamaica More articles by this author , and Marvin ReidMarvin Reid Kingston 6, Jamaica More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.1136AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Hypogonadism is common in men with sickle cell disease. We sought to determine differences in hypothalamus-pituitary-gonadal axis, and the effect of these differences on cholesterol, body and bone composition in adult males with sickle cell disease. METHODS This was a cross-sectional study of 50 men with homozygous S sickle cell disease and 52 age-matched controls with hemoglobin AA. All patients had early morning blood taken for free and total testosterone, follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin, lipid levels, lactate dehydrogenase (LDH) and hematological indices. Weight (kg) and height (m) were measured. Bone mineral content, density and body composition were measured by Dual Xray Absorptiometry. RESULTS Hypogonadism (testosterone < 12.5 nmol/l) was seen in 20 (19.6%) patients with a greater proportion in the sickle cell group (26% vs 13%).Total (16.0 ± 5.4 vs 19.4 ± 8.3 nmol/L, mean±sd, p=0.01), free testosterone (30.7±12.2 vs 42.7±17.1 pmol/L, p<0.0001) and total cholesterol concentrations (3.0±0.6 vs 4.7±0.9, p=0.001) were significantly lower in the SCD group. In contrast serum FSH (7.2 ± 4.7 vs 4.2 ± 2.3 IU/L, p<0.001), LH (7.2 ±3.2 vs 5.1±3.0, p<0.002) and prolactin (220±170 vs 152±63, p<0.009) were significantly higher in the SCD group. Weight, lean mass, body mass index and measures of bone structure (whole body bone density score, 1.2±0.1 vs 1.3±0.1, p<0.001; total bone mass kg, 2.8±0.6 vs 3.4±0.4, p<0.001; t- score,−0.2±1.8 vs 1.0±1.2, p<0.001) were lower in SCD group compared with AA controls. CONCLUSIONS Hypogonadism is common in sickle cell disease and is due to primary testicular failure. Adult males with sickle cell disease are more wasted with lower bone composition and lipid levels compared with AA controls. Body composition and anthropometric measures in sample Mean Serum Hormone Levels Patients with sickle cell disease Controls (AA genotype) p Value Mean±s.d.Total Testosterone (nmol/L) 16.0±5.4 19.4±8.3nmol/L 0.01 Mean±s.d.Free Testosterone (pmol/L) 30.7±12.2 42.7±17.1 0.0001 FSH (IU/L) 7.1±4.7 4.2±2.3 0.0002 LH (IU/L) 7.1±3.2 5.1±3.0 0.001 Prolactin (mIU/L) 219.8±169.8 152.3±63.4 0.008 Body composition and anthropometric measures in sample Variable Patients with sickle disease Controls (AA genotype) p value Total Cholesterol (mM/L) 3.0 4.7 <0.001 HDL Cholesterol (mM/L) 0.9 1.3 <0.001 LDL Cholesterol (mM/L) 1.6 2.9 <0.001 Triglycerides (mM/L) 1.2 1.4 0.2 Cholesterol/ HDL Cholesterol 3.6 3.9 0.2 Hemoglobin (g/dl) 7.8 14.3 <0.001 MCV (fL) 104.0 88.5 0.36 MCH (pg) 29.8 29.1 0.29 MCHC (g/dl) 34.0 32.7 <0.001 WBC (109/L) 10.7 5.7 <0.001 Plt (109/L) 377.8 259.9 <0.001 LDH IU/L 1315.6 619.3 <0.001 Body composition and anthropometric measures in sample Variable (mean±sd) Patients with Sickle Cell Disease Controls (AA genotype) p value Height (cm) 175±7.7 174.6±6.9 0.7 Weight (kg) 62.2±9.4 79.9±13.5 <0.001 BMI (kg/m2) 20.2±2.7 26.2±4.3 <0.001 Lean mass (kg) 50.4±6.3 58.5±6.4 <0.001 Bone mass (kg) 2.8±0.6 3.4±0.4 <0.001 Absolute whole body bone density 1.2±0.1 1.3±0.1 <0.001 T score −0.2±1.8 1.0±1.3 <0.001 Z score −0.6±1.7 −0.1±1.1 0.1 © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e526-e527 Peer Review Report Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Belinda Morrison Kingston 6, Jamaica More articles by this author Suzanne Soares-Wynter Kingston 6, Jamaica More articles by this author Wendy Madden Kingston 6, Jamaica More articles by this author Marvin Reid Kingston 6, Jamaica More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...