The aim of this work was to utilize Perlis Sunshine Mango Seed Flour (MSF) as natural active ingredient in body scrub for skin care cosmetology. The body scrubs were prepared in two forms i.e. rough salt and oil-in-water (O/W) emulsion. Both types of body scrub were formulated as based and containing Perlis Sunshine MSF. The determination of total phenolic content (FC-reagent method), ascorbic acid content (HPLC) and total antioxidant activity (DPPH method) of the body scrubs were evaluated for the possible application in dermo-cosmetic field. The O/W MSF body scrub extract contains 6.65 ± 0.16 GAE mg/g of total phenolic content (TPC) with 32.29 ± 2.60% of DPPH activity inhibition. The rough salt MSF body scrub extract had shown highest ascorbic acid content compared to other body scrubs. For the sensory analysis, most of the body scrubs testers satisfied with the O/W body scrubs compared to rough salt body scrubs in all the attributed tested.