Rehabilitation of paralysis caused by a stroke or a spinal cord injury remains a complex and time-consuming task. This work proposes a hybrid exoskeleton approach combining a traditional exoskeleton and functional electrical stimulation (FES) as a promising method in rehabilitation. However, hybrid exoskeletons with a closed-loop FES control strategy are functionally challenging to achieve and have not been reported often. Therefore, this study aimed to investigate a powered lower-limb exoskeleton with a closed-loop FES control for Sit-to-Stand (STS) movements. A body motion capture system was applied to record precise hip and knee trajectories of references for establishing the human model. A closed-loop control strategy with allocation factors is proposed featuring a two-layer cascaded proportional–integral–derivative (PID) controller for both FES and exoskeleton control. Experiments were performed on two participants to examine the feasibility of the hybrid exoskeleton and the closed-loop FES control. Both open- and closed-loop FES control showed the desired performance with a relatively low root-mean-squared error (max 1.3∘ in open-loop and max 4.1∘ in closed-loop) in hip and knee trajectories. Notably, the closed-loop FES control strategy can achieve the same performance with nearly 60% of the electrical power input compared to the open-loop control, which reduced muscle fatigue and improved robustness during the training. This study provides novel insights into body motion capture application and proposes a closed-loop FES control for hybrid exoskeletons.