Body Functions Research Articles

Rhodiola Rosea: a plant from the Crassulaceae family that has the potential to reduce muscle pain and increase range of motion during exercise-induced muscle damage

This study aims to analyze the potential of rhodiola rosea in reducing muscle pain and increasing ROM during EIMD. This experimental research uses a pre- and post-control group design. Research subjects were selected using a purposive sampling technique, then the subjects were divided into 2 groups, namely group (K1) which was given placebo and group (K2) which was given rhodiola rosea at a dose of 500 mg. A total of 18 healthy men aged between 19-25 years participated in this study. Data collection began on the first day by collecting data on subject characteristics. After that, they were asked to warm up. Physical activity is carried out afterward. These activities include high-intensity activities, such as walking lunges, good mornings, and leg extensions. This exercise is done in 4 sets with a 1-minute break (recovery) between sets. Exercise intensity is monitored using a Polar H9 Heart Rate Sensor. On day 2 or 24 hours after training, subjects took pre-test data to measure muscle soreness and ROM. Subjects were then given placebo or rhodiola rosea treatment, depending on the group assigned. On the 3rd day or 48 hours after training, post-test data was collected again. Muscle intensity was measured using a Visual Analog Scale (VAS) and ROM was measured at the knee joint using a goniometer. After the data was obtained, the data were analyzed using the IBM SPSS version 26 application. The results of this study reported that the K1 group given placebo did not significantly reduce muscle pain and increase ROM during EIMD, while the K2 group given rhodiola rosea at a dose of 500 mg significantly reduced pain. muscle and increase ROM during EIMD. Considering that pain management and ROM are very necessary to support body function, we recommend the use of rhodiola rosea for sports enthusiasts to support physical performance. Keywords: Rhodiola Rosea, Muscle Pain, Range of Motion, Exercise-Induced Muscle Damage, Inflammation, Healthy lifestyle

Harmful Health Impacts of Heavy Metals and Behavioral Changes in Humans

Heavy metal pollution not only affects the environment but also the behavior of people who are greatly dependent on their surrounding environment for their survival. There are both natural and anthropogenic sources of heavy metals but their pollution by manmade activities are quite faster than natural sources. A person gets exposed to heavy metals by four major exposure pathways i.e. inhalation, ingestion, dermal exposure and injection. After exposure to heavy metals, internal normal body functions of an individual gets disturbed. This in turn alters the human behavior from normal to an abnormal state. Various behavioral changes are associated with heavy metals exposure such as depression, anxiety, irregular heartbeats, stress, decrease in strength and power, lack of confidence, restlessness, lack of tolerance and aggressions among the individuals and the society as a whole. This review entails the information regarding sources of heavy metals, exposure pathways and health effects of heavy metals resulting in behavioral changes in humans.

Functional priorities of individuals with spinal cord injury: a Saudi Arabian perspective.

People with spinal cord injury (SCI) are the deciding force behind the rehabilitation program to improve their quality of life (QoL) based on their personal preferences. Here we aimed to determine the preferences perceived most vital by Saudi SCI population to improve their QoL, and explore if these preferences are affected by gender, education, and duration, level, or extent of injury. Participants ranked seven priorities of bodily functions as Rank I-VII with "I" being "Most important," and "VII" being "Least important." Inpatient rehabilitation facility. 120 participants (>18 years of age) of either sex with SCI without polytrauma, acquired brain injury, neurodegenerative disease, and dementia. Ranking scale of seven priorities of bodily functions as Rank I-VII with "I" being "Most important," and "VII" being "Least important." Of 101 individuals (mean age: 35.2 ± 14.8 years) finally included, 70.3% were males, 66.3% had onset of SCI since ≥ 3 years, 48.5% had a complete injury, and 75% had paraplegia. Most (26.7%) participants ranked walking as the first priority followed by hand/arm function (20.8%). Sexual function was the least important priority (39.6%). Hand/arm function was significantly more important for individuals with tetraplegia (p < 0.001). Trunk strength and balance was significantly less important for individuals with complete injury (p = 0.037). Participants with the onset of injury < 3 years and a complete injury reported bladder/bowel function as significantly more important (p = 0.011). Walking was significantly more important for people with incomplete injury and for people with injury duration ≥ 3 years (p = 0.022, p = 0.002 respectively). The top priority in our sample of Saudi people with SCI was walking followed by hand/arm function while the least desired function was regaining sexual function. Walking was a prioritized function for people with injury duration ≥ 3 years and people with a complete injury while hand/arm function was highly prioritized by people with tetraplegia.

Gambaran Karakteristik Demografi Dan Perkembangan Pada Anak Usia 2-5 Tahun di Puskesmas Kesesi I

The development of children under five is an increasingly complex body structure and function that occurs in a regular and predictable pattern as a maturation process. Children's development can be assessed from their speech and language abilities, fine or gross motor skills, cognitive intelligence, and social or emotional abilities. This study aims to describe the demographic and developmental characteristics of stunted children aged 2-5 years at the Kesesi I health center. This research is a descriptive study. This sampling technique used total sampling, the population of this study was 38 children at the Kesesi I Community Health Center. This research instrument used the Pre-Developmental Screening Questionnaire (KPSP) which was recommended by the Ministry of Health of the Republic of Indonesia for use in this study, so validity and reliability tests were not carried out. . The data analysis used was univariate in the form of a percentage frequency distribution. The results of this study show that the average child at the Kesesi I Community Health Center is 42 months old. Male gender (71.1%), spontaneous birth (81.6%), term gestation (37-42 weeks) (81.6%), weight at birth with sufficient birth weight (2500-4000 grams) (89.5%), current BB in the normal category (68.4%), current TB in the normal category (60.5%) and (100%) children have a history of breastfeeding. The development of toddlers at the Kesesi I Community Health Center shows that (55%) of respondents have doubtful development. The conclusion obtained is that 55% of the demographic and developmental characteristics of stunted children aged 2-5 years at the Kesesi I Community Health Center have doubtful development.

LIVER ULTRASOUND IMAGING LESION DETECTION BASED ON YOLO

The liver is a silent organ with no pain-sensing nerves. When the body's functions begin to appear abnormal, it may have entered the trilogy of liver diseases: "hepatitis, cirrhosis, and liver cancer." An abdominal ultrasound is a powerful tool for checking liver health. With the rapid development of ultrasound technology, ultrasound machines are gradually developing in the direction of miniaturization and cheapness, transforming from hospital-specific equipment to home medical equipment. However, ultrasound diagnosis requires professional knowledge, which has also become the threshold for the popularization of ultrasound diagnosis. This article uses artificial intelligence and machine learning technology to take the liver ultrasound images marked by professional doctors as a data set. After training of image object detection model YOLO, it can be used to detect tumors, hepatic hemangioma, radiofrequency cautery, abscess and metastatic, the accuracy can reach 98%.

Like Mother, Like Daughter? Double Standards in Body Evaluation and Their Familial Transmission in Female Adolescents and Their Mothers

BackgroundCognitive biases, such as applying stricter body evaluation for oneself than for others, are presumed to promote the development and maintenance of eating disorders. While questionnaire data have demonstrated a familial transmission of body image, these self-deprecating double standards (DS) have not been studied among female adolescents, and a potential familial transmission of DS through feedback/role-modeling is yet to be explored. The present study thus addresses these questions.MethodsFemale adolescents and their mothers viewed pictures of their own and peer bodies presented with their own and another peer’s face, and were asked to rate arousal, valence, body attractiveness, and body fat for each body.ResultsDaughters evaluated their own, an average-weight, and an overweight build as less attractive and with more body fat when presented with their own than with another face, while mothers mainly applied such self-deprecating DS for an overweight build. Regarding familial transmission, higher negative maternal feedback was associated with more self-deprecating DS of body fat and attractiveness in daughters when viewing an overweight build.ConclusionsFemale adolescents and their mothers apply self-deprecating DS, suggesting that DS are widespread. Psychoeducation and training regarding communication, feedback, and body functionality might support the prevention of DS.

Effects of Endurance Training on Antioxidant and Hormonal Status in Peripheral Blood of Young Healthy Men.

(1) Background: Physical activity may cause an imbalance in the major functions of the human body. This study aimed to investigate the effects of endurance running training on the parameters of the antioxidant defense system (SOD, CAT, GPx, GR, GSH), LPO (malondialdehyde, MDA), and stress hormones (A, NA) in young healthy, previously untrained men. (2) Methods: The training program was as follows: 8 weeks of running, three times per week; the duration of a single session was 30-70 min, the intensity was twice a week in the so-called extensive endurance zone, and once a week in the anaerobic threshold zone. Blood samples were collected from the subjects, before and after the running program. (3) Results: The training program resulted in a significant increase in maximal oxygen consumption (p < 0.001). The activities of SOD, GPx, and GR also increased significantly (p < 0.05, p < 0.01, and p < 0.05, respectively), while CAT activity and GSH and MDA concentrations remained unchanged. The concentration of A decreased (p < 0.05), while the NA concentration increased significantly (p < 0.05). SOD, GPx, GR, and NA positively correlated with VO2max (p < 0.05, p < 0.001, p < 0.01, p < 0.05, respectively), while a negative correlation was detected between A and VO2max (p < 0.05). (4) Conclusions: These results indicate that there is no persistent oxidative stress in response to the applied 8-week running program, probably due to exercise-induced protective alterations in the antioxidant defense system. Furthermore, adaptations occurred at the hormonal level, making the organism more ready for a new challenge.

Combined non-targeted and targeted metabolomics reveals the mechanism of delaying aging of Ginseng fibrous root.

Background: The fibrous root of ginseng (GFR) is the dried thin branch root or whisker root of Ginseng (Panax ginseng C. A. Mey). It is known for its properties such as tonifying qi, producing body fluid, and quenching thirst. Clinically, it is used to treat conditions such as cough, hemoptysis, thirst, stomach deficiency, and vomiting. While GFR and Ginseng share similar metabolites, they differ in their metabolites ratios and efficacy. Furthermore, the specific role of GFR in protecting the body remains unclear. Methods: We employed ultra-high performance liquid chromatography-triple quadrupole mass spectrometry to examine alterations in brain neurotransmitters and elucidate the impact of GFR on the central nervous system. Additionally, we analyzed the serum and brain metabolic profiles of rats using ultra-high performance liquid chromatography-quadrupole-orbitrap mass spectrometry to discern the effect and underlying mechanism of GFR in delaying aging in naturally aged rats. Results: The findings of the serum biochemical indicators indicate that the intervention of GFR can enhance cardiovascular, oxidative stress, and energy metabolism related indicators in naturally aging rats. Research on brain neurotransmitters suggests that GFR can augment physiological functions such as learning and memory, while also inhibiting central nervous system excitation to a certain degree by maintaining the equilibrium of central neurotransmitters in aged individuals. Twenty-four abnormal metabolites in serum and seventeen abnormal metabolites in brain could be used as potential biomarkers and were involved in multiple metabolic pathways. Among them, in the brain metabolic pathways, alanine, aspartate and glutamate metabolism, arginine and proline metabolism, histidine metabolism, and tyrosine metabolism were closely related to central neurotransmitters. Butanoate metabolism improves energy supply for life activities in the aging body. Cysteine and methionine metabolism contributes to the production of glutathione and taurine and played an antioxidant role. In serum, the regulation of glycerophospholipid metabolism pathway and proline metabolism demonstrated the antioxidant capacity of GFR decoction. Conclution: In summary, GFR plays a role in delaying aging by regulating central neurotransmitters, cardiovascular function, oxidative stress, energy metabolism, and other aspects of the aging body, which lays a foundation for the application of GFR.

MC4R Localizes at Excitatory Postsynaptic and Peri-Postsynaptic Sites of Hypothalamic Neurons in Primary Culture.

The melanocortin-4 receptor (MC4R) is a G protein-coupled receptor (GPCR) that is expressed in several brain locations encompassing the hypothalamus and the brainstem, where the receptor controls several body functions, including metabolism. In a well-defined pathway to decrease appetite, hypothalamic proopiomelanocortin (POMC) neurons localized in the arcuate nucleus (Arc) project to MC4R neurons in the paraventricular nuclei (PVN) to release the natural MC4R agonist α-melanocyte-stimulating hormone (α-MSH). Arc neurons also project excitatory glutamatergic fibers to the MC4R neurons in the PVN for a fast synaptic transmission to regulate a satiety pathway potentiated by α-MSH. By using super-resolution microscopy, we found that in hypothalamic neurons in a primary culture, postsynaptic density protein 95 (PSD95) colocalizes with GluN1, a subunit of the ionotropic N-methyl-D-aspartate receptor (NMDAR). Thus, hypothalamic neurons form excitatory postsynaptic specializations. To study the MC4R distribution at these sites, tagged HA-MC4R under the synapsin promoter was expressed in neurons by adeno-associated virus (AAV) gene transduction. HA-MC4R immunofluorescence peaked at the center and in proximity to the PSD95- and NMDAR-expressing sites. These data provide morphological evidence that MC4R localizes together with glutamate receptors at postsynaptic and peri-postsynaptic sites.

HUBUNGAN ANTARA STATUS SOSIAL EKONOMI KELUARGA DENGAN STATUS GIZI ANAK USIA SEKOLAH DI SD NEGERI 14 NAN SABARIS

Nutritional status describes the balance between the body's need for nutrients to maintain life, growth, development, maintenance of normal body functions and for energy production and other nutrient intake. The purpose of this study was to determine the relationship between family socio-economic status and the nutritional status of school-age children at SD Negeri 14 Nan Sabaris. This study used a descriptive analytical research type with a research design using a Cross Sectional approach. The population in this study was The population in this study were students of SD Negeri 14 Nan Sabaris District, Padang Pariaman Regency. Samples were taken using the simple random sampling method, or a simple random design. The sample in this study was 61 respondents. The univariate analysis results are displayed in the form of a frequency distribution of economic and nutritional status. Bivariate analysis using chi square at α = 0.05%. The results of the study obtained a high socio-economic status category of 18 people (29.5%), moderate there were 9 people (14.8%) and low as many as 34 people (55.7%). While the nutritional status of school children in the normal category was 30 people (49.2%) and thin as many as 31 people (50.8%). In conclusion, there is a significant relationship between socioeconomic status and nutritional status of school children at SDN 14, Nan Sabaris District.

Correlation between Alzheimer's Disease and Gastrointestinal Tract Disorders.

Alzheimer's disease is the most common cause of dementia globally. The pathogenesis is multifactorial and includes deposition of amyloid-β in the central nervous system, presence of intraneuronal neurofibrillary tangles and a decreased amount of synapses. It remains uncertain what causes the progression of the disease. Nowadays, it is suggested that the brain is connected to the gastrointestinal tract, especially the enteric nervous system and gut microbiome. Studies have found a positive association between AD and gastrointestinal diseases such as periodontitis, Helicobacter pylori infection, inflammatory bowel disease and microbiome disorders. H. pylori and its metabolites can enter the CNS via the oropharyngeal olfactory pathway and may predispose to the onset and progression of AD. Periodontitis may cause systemic inflammation of low severity with high levels of pro-inflammatory cytokines and neutrophils. Moreover, lipopolysaccharide from oral bacteria accompanies beta-amyloid in plaques that form in the brain. Increased intestinal permeability in IBS leads to neuronal inflammation from transference. Chronic inflammation may lead to beta-amyloid plaque formation in the intestinal tract that spreads to the brain via the vagus nerve. The microbiome plays an important role in many bodily functions, such as nutrient absorption and vitamin production, but it is also an important factor in the development of many diseases, including Alzheimer's disease. Both the quantity and diversity of the microbiome change significantly in patients with AD and even in people in the preclinical stage of the disease, when symptoms are not yet present. The microbiome influences the functioning of the central nervous system through, among other things, the microbiota-gut-brain axis. Given the involvement of the microbiome in the pathogenesis of AD, antibiotic therapy, probiotics and prebiotics, and faecal transplantation are being considered as possible therapeutic options.

Synergistic Effect of β-Cryptoxanthin and Epigallocatechin Gallate on Obesity Reduction.

Chronic obesity is an alarmingly growing global public health concern, posing substantial challenges for the prevention of chronic diseases, including hyperinsulinemia, type 2 diabetes, hyperlipidemia, hypertension, and coronary artery disease, and there is an urgent need for early mitigation strategies. We previously reported the obesity-reducing effects of green tea and β-cryptoxanthin intake. However, since tea has a complex mixture of compounds, it remained unclear which component contributed the most to this effect. Using high-performance liquid chromatography, we analyzed the components of tea in this study to determine if consumption of any combination of these compounds with β-cryptoxanthin had an obesity-reducing effect. Consuming epigallocatechin gallate (EGCG), a component of green tea, and β-cryptoxanthin for 4 weeks led to a decrease in body weight. Moreover, the weight and size of the white adipose tissues were significantly reduced, and blood biochemistry test results were comparable to normal values, with particular improvement in liver function. This indicated that intake of EGCG and β-cryptoxanthin reduces obesity in both subcutaneous and visceral fat. These findings suggest that simultaneous intake of EGCG and β-cryptoxanthin not only reduces obesity but also has a systemic beneficial effect on the body's normal physiological function.

Ganoderma pfeifferi Bres. and Ganoderma resinaceum Boud. as Potential Therapeutic Agents: A Comparative Study on Antiproliferative and Lipid-Lowering Properties.

Medicinal mushrooms, especially Ganoderma species, hold immense promise for the production of a wide range of bioactive compounds with various effects. The biochemical potential of indigenous fungal strains, specific to a region, could play a critical role in the continuous search for novel strains with superior activities on a global scale. This research focused on the ethanolic (EtOH) and hot-water (H2O) extracts of fruiting bodies of two wild-growing Ganoderma species: G. pfeifferi and G. resinaceum, with the aim of assessing their nutritional (total carbohydrate content-TCC) and mineral composition in relation to bioactive properties: antioxidant, antiproliferative and lipid-lowering. Atomic absorption spectrophotometry (AAS) revealed that G. pfeifferi is a promising source of minerals that are essential for numerous physiological functions in the human body like bone health and muscle and nerve function, with Ca (4.55 ± 0.41 mg/g d.w.) and Mg (1.33 ± 0.09 mg/g d.w.) being the most abundant macroelement present. Zn, Mn, and Cr were particularly notable, with concentrations ranging from 21.49 to 41.70 mg/kg d.w. The EtOH extract of G. pfeifferi demonstrated significantly elevated levels of TCC, essential macromolecules for energy and structural functions in the body, with higher quantities of all three standard carbohydrates detected in this type of extract. Similar to the revealed composition, the same species, G. pfeifferi, stood out as the most prominent antioxidant agent, with the H2O extract being stronger than EtOH in the ABTS assay (86.85 ± 0.67 mg TE/g d.w.), while the EtOH extract displayed the highest anti-OH• scavenging ability (IC50 = 0.18 ± 0.05 μg/mL) as well as the most notable reducing potential among all. The highest antiproliferative effect against the breast cancer cell line (MCF-7), were demonstrated by the H2O extracts from G. resinaceum with the most pronounced activity after 24 h (IC50 = 4.88 ± 0.50 μg/mL), which surpasses that of the standard compound, ellagic acid (IC50 = 33.94 ± 3.69 μg/mL). Administration of both Ganoderma extracts mitigated diabetic lipid disturbances and exhibited potential renal and hepatic protection in vivo on white Wistar rats by the preservation of kidney function parameters in G. resinaceum H2O pre-treatment (urea: 6.27 ± 0.64 mmol/L, creatinine: 50.00 ± 6.45 mmol/L) and the reduction in ALT levels (17.83 ± 3.25 U/L) compared to diabetic control groups treated with saline (urea: 46.98 ± 6.01 mmol/L, creatinine: 289.25 ± 73.87 mmol/L, and ALT: 60.17 ± 9.64 U/L). These results suggest that pre-treatment with G. resinaceum H2O extracts may have potential antidiabetic properties. In summary, detected microelements are vital for maintaining overall health, supporting metabolic processes, and protecting against various chronic diseases. Further research and dietary assessments could help determine the full potential and applications of the two underexplored Ganoderma species native to Serbia in nutrition and health supplements.

Evaluation of the Effectiveness of the Elderly Cognitive and Exercise Forest Therapy Program According to Brain Wave and Autonomic Nervous System Parameters

The purpose of this study is to more quantitatively identify changes in body function through various bio-signal parameters. (1) Background: Forest therapy is effective in stabilizing cognitive, emotional, cardiovascular, and autonomic nervous systems. In particular, it is necessary to more quantitatively confirm changes in body functions through various bio signals. (2) Methods: As a forest therapy program (FTP) for the elderly, it consisted of strength training in the forest, respiratory aerobic exercises, and cognitive function training, and a total of 19 sessions were performed for 12 weeks. The electroencephalography (EEG) and Photoplethysmography (PPG) before and after the program were measured and compared between program participants (FTP group) and non-participants (control group). (3) Results: the FTP group showed increase in the alpha band power in EEG and a decrease in the PRV index, Tad, and Tae after the program compared to the control group; (4) Conclusions: Significant differences occurred in the physiological functioning of the elderly participants after the program. This is a result that can confirm the effectiveness of forest therapy more quantitatively. Forest therapy has a positive effect on mental stress reduction and cardiovascular function.

Can International Classification of Functioning, Disability and Health (ICF) Be Used for Prediction of Work Capacity and Employment Status in Multiple Sclerosis?

Background: Multiple sclerosis (MS) affects many body functions and activities, including work capacity and ability to work. An evaluation of work-related parameters is important to understand the barriers to maintaining the job. The aim of this study was to evaluate if a Comprehensive International Classification of Functioning, Disability and Health (ICF) core set for MS can be used to predict work capacity and employment status. Methods: The cohort included 151 participants with MS (99 female/52 male, mean age 49 years) referred for a work capacity evaluation. Results: 71 (47.0%) were employed and a major part (131, 86.7%) had a work capacity between 20 and 40% with no difference between those who were employed and those who were unemployed. The analysis revealed that age and the following categories explained 68.8% of the work capacity: b770 Gait pattern functions; b730 Muscle power functions; b134 Sleep functions; d845 Acquiring, keeping and terminating a job; and b620 Urination functions. The following categories in 79.5% predicted ability to work: b164 Higher-level cognitive functions; d510 Washing oneself; d630; Preparing meals; and d870 Economic self-sufficiency. Conclusions: Here, we show that different functions/activities predicted work capacity in comparison with employment status in MS. Therefore, ICF should be implemented when assessing work ability.

Vitamin D in Central Nervous System: Implications for Neurological Disorders.

Vitamin D, obtained from diet or synthesized internally as cholecalciferol and ergocalciferol, influences bodily functions through its most active metabolite and the vitamin D receptor. Recent research has uncovered multiple roles for vitamin D in the central nervous system, impacting neural development and maturation, regulating the dopaminergic system, and controlling the synthesis of neural growth factors. This review thoroughly examines these connections and investigates the consequences of vitamin D deficiency in neurological disorders, particularly neurodegenerative diseases. The potential benefits of vitamin D supplementation in alleviating symptoms of these diseases are evaluated alongside a discussion of the controversial findings from previous intervention studies. The importance of interpreting these results cautiously is emphasised. Furthermore, the article proposes that additional randomised and well-designed trials are essential for gaining a deeper understanding of the potential therapeutic advantages of vitamin D supplementation for neurological disorders. Ultimately, this review highlights the critical role of vitamin D in neurological well-being and highlights the need for further research to enhance our understanding of its function in the brain.

Small RNA and Freeze Survival: The Cryoprotective Functions of MicroRNA in the Frozen Muscle Tissue of the Grey Tree Frog.

The grey tree frog, Dryophytes versicolor, survives whole-body freezing for weeks during cold winter months. Survival in a state devoid of available food, water, or oxygen forces a reliance on metabolic rate depression (MRD) and the reprioritization of bodily functions. This study utilizes next-generation sequencing (NGS) and bioinformatic analyses to characterize changes in the microRNAome of D. versicolor. When comparing control to frozen groups, five microRNAs (miRNA) were found to be differentially regulated (miR-143-3p, miR-30e-3p, miR-10a-5p, miR-140-3p, and miR-148a-3p), suggesting that they play key roles in freeze survival. The KEGG and GO analyses of these changes predicted a significant negative enrichment of terms associated with cell proliferation and active metabolism while simultaneously predicting the upregulation of cell signalling terms. These results suggest a fast-acting regulatory role for miRNA in contributing to the reorganization of gene expression and the limitation of energy-expensive processes during MRD in the hind leg skeletal muscle of the frog.

Rapid benefits in older age from transition to whole food diet regardless of protein source or fat to carbohydrate ratio: Arandomised control trial.

Plant-based diets reduces the risk of chronic conditions. The interaction between protein source and other macronutrients-fat (F) and carbohydrate (C)-has yet to be investigated. The aim was to assess the main and interactive effects of protein-source (plant vs. animal) and F:C (high or low) and the transition from an Australian diet to a whole food diet on various health markers in older individuals. This single-blinded, parallel, randomised experimental trial used a 2 × 2 factorial design to compare pro-vegetarian (70:30 plant to animal) versus omnivorous (50:50 plant to animal) diets at 14% protein and varying fat-to-carbohydrate ratios (high fat ~40% vs. low fat ~30%) over 4 weeks. Study foods were provided, alcohol consumption was discouraged, and dietary intake was determined through food records. Analysis included both RCT and observational data. Changes in appetite, palatability of diets, and dietary intake were assessed. Body composition, muscle strength, function, gut microbiome, and cardiometabolic health parameters were measured. Data from 113 (of the 128 randomised) individuals aged 65-75 years were analysed. Pro-vegetarian diets reduced diastolic blood pressure, total cholesterol and glucose levels. Moreover, the overall sample exhibited increased short-chain fatty acids and FGF21 levels, as well as improvements in body composition, function, and cardio-metabolic parameters irrespective of dietary treatment. Transitioning to a diet rich in fruit, vegetables, fibre, and moderate protein was associated with improved health markers in older age, with added benefits from pro-vegetarian diets. Further research on long-term effects is needed.

Convective heat transfer with Hall current using magnetized non-Newtonian Carreau fluid model on the cilia-attenuated flow

PurposeCilia serves numerous biological functions in the human body. Malfunctioning of nonmotile or motile cilia will have different kinds of consequences for human health. More specifically, the directed and rhythmic beat of motile cilia facilitates the unidirectional flow of fluids that are crucial in both homeostasis and the development of ciliated tissues. In cilia-dependent hydrodynamic flows, tapering geometries look a lot like the structure of biological pathways and vessels, like airways and lymphatic vessels. In this paper, the Carreau fluid model through the cilia-assisted tapered channel (asymmetric) under the influence of induced magnetic field and convective heat transfer is investigated.Design/methodology/approachLubrication theory is a key player in the mathematical formulation of momentum, magnetic field and energy equations. The formulated nonlinear and coupled differential equations are solved with the aid of the homotopy perturbation method (HPM). The graphical results are illustrated with the help of the computational software “Mathematica.”FindingsThe impact of diverse emerging physical parameters on velocity, induced magnetic field, pressure rise, current density and temperature profiles is presented graphically. It is observed that the cilia length parameter supported the velocity and current density profiles, while the Hartman number and Weissenberg number were opposed. A promising effect of emerging parameters on streamlines is also perceived.Originality/valueThe study provides novel aspects of cilia-driven induced magnetohydrodynamics flow of Carreau fluid under the influence of induced magnetic field and convective heat transfer through the asymmetric tapered channel.

Analisis Kritis Critical Book Review Buku Ajar Anatomi Fisiologi Karya Heni Puji Wahyuningsih dan Yuni Kusmiyati

Critical book review is one of the mandatory assignments given to students to review a book in the sense of focusing on evaluation (explanation, interpretation, and analysis) of the book's strengths and weaknesses and how the book affects the way of thinking and increases understanding of a field of study. Teaching materials for Physiological Anatomy by Heni Puji Wahyuningsih and Yuni Kusmiyati are a comprehensive learning resource to understand the structure and function of the human body. This book discusses various organ systems in detail, from the cellular to the macroscopic level. Its clear explanations and informative pictures make this book easy for readers to understand. This study aims to find out the discussion of teaching materials in detail. This study uses a literature study method, namely collecting data from various literature or scientific references and physiological anatomy books. The results of the critical analysis of the research are teaching materials discussing the physiological anatomy of the human body, where anatomy is the study of the structure and relationships between body parts of living things, and physiology is the study of the study of the function of body parts