This article studies the finite time blow-up of weak solutions to a structural acoustics model consisting of a semilinear wave equation defined on a bounded domain Ω⊂R3 which is strongly coupled with a Berger plate equation acting on the elastic wall, namely, a flat portion of the boundary. The system is influenced by several competing forces, including boundary and interior source and damping terms. We stress that the power-type source term acting on the wave equation is allowed to have a supercritical exponent, in the sense that its associated Nemytskii operator is not locally Lipschitz from H1 into L2. In this paper, we prove the blow-up results for weak solutions when the source terms are stronger than damping terms, by considering two scenarios of the initial data: (i) the initial total energy is negative; (ii) the initial total energy is positive but small, while the initial quadratic energy is sufficiently large. The most significant challenge in this work arises from the coupling of the wave and plate equations on the elastic wall.