Introduction: The interventional and medical treatment modalities used in the treatment of iliofemoral venous thrombosis were analyzed in terms of outcome, efficiency and the risk of postthrombotic syndrome were analyzed. Methods: Patients who were treated for iliofemoral deep venous thrombosis (DVT) by means of medial and interventional methods were retrospectively analyzed from hospital records and phone interviews. The interventional group (Group I) consisted of 35 patients and the medically treated group (Group M) consisted of 182 patients. The average age of the patients in Group I and Group M were 49.8±16.7 (20-89) and 51.4±18.4 (15-96), respectively (p=0.628). Patients having DVT as provoked/unprovoked, Lower Extremity Thrombosis (LET) scale, final Venous Clinical Severity Scores (VCSS) and Villalta scores in the final interviews were recorded. The LET classification was made based on the initial Doppler USG results. Results: No patients had any mortality in the acute period. Follow-up was complete in 107 patients. The average duration of follow-up was 2.6±2.5 years (1 month-19.7 years), adding up to a total of 278.5 patient/years. The follow-up duration was Group I had more number of proximal involvement according to LET classification (p=0.0001). The rate of recurrent DVT was 22.9% (8 cases) and 13.9% (23 cases) in Group I and Group M, respectively (p=0.198). The average recurrence-free survival durations in Group I and Group M were 1.6±1.8 and 2.2±3.3 years, respectively (p=0.130). The 1- and 2-years recurrence-free survival rates in Group I and Group M were 80.0%±8.1%, 73.3%±9.8% and 92.9%±2.2%,%85.9%±3.7%; respectively (p=0.479) (Graph-1). None of the Group I patients had pulmonary emboli (PE) during follow-up. In Group M, 5 patients had PE during follow-up (p=0.614). The 1, 2 years PE-free survival rate in Group M was 97.1%±2.0% and at 5 years 87.9%±6.6%. The difference between groups were nonsignificant (p=0.312). In the final controls, average Villalta scores in Group I and Group M were 3.0±2.6 (0-11) and 3.0±2.6 (0-11), respectively (p=0.013). The number of patients with Villalta scores >5 were 1 in Group I (3.4%) and 32 in Group M (41.0%) (p=0.0001). The average VCSS were statistically different in Group I and Group M (2.6±3.5 (0-16) and 4.4±3.6 (0-18), respectively) (p=0.027). Anticoagulant related bleeding complications occurred in 8 patients in Group I (27.6%) and in 32 patients in Group M (41.0%) (p=0.195). Conclusion: Although the results of ATTRACT Trial caused a significant debate, interventional treatment after DVT results in lower VCSS and Villalta scores at 2 years. The rate of posthrombotic syndrome is significantly low in patients who received interventional treatment. Interventional therapy options in iliofemoral DVT offers persistent advantage in mid-term follow-up. Disclosure: Nothing to disclose