Signet Ring Cell Carcinoma Of Bladder Research Articles

Primary Signet Ring Cell Mucinous Adenocarcinoma of the Urinary Bladder: A Rare Case Report

Primary ‘signet ring mucinous adenocarcinoma’ is most commonly located in the stomach. The bladder is an uncommon presentation site for the primary location of this tumor. Mucinous signet-ring adenocarcinoma with urinary bladder as the primary origin is uncommon, accounting for fewer than two percent of all upper urinary tract carcinomas. The presence of signet ring cells, which is caused by compression and displaced nucleus of the cell into a crescent placed in the periphery along the cell wall, is a distinguishing feature of signet ring cell carcinoma. These cells are loaded with cytoplasmic mucus-containing vacuoles. Lower than one-third of primary bladder signet ring cell carcinoma cases show this gross morphology showing linitis plastica pattern with subepithelial infiltration without producing an exophytic mass in a pure signet ring cell carcinoma. Because this tumor shares histological features with the adenocarcinomas originating in several other sites, such as the prostate, digestive tract, and reproductive system, immunohistochemistry tests are required to confirm the bladder as the primary origin. Owing to the paucity of the neoplasm and the difficulty in locating the underlying tumor, site identification is frequently prolonged, leaving palliative care as the only choice for roughly half of the patients. This study depicts a rare case report of primary vesicular signet ring cell mucinous adenocarcinoma that considerably invades the pelvis and retroperitoneum's prostate and lymph nodes. This case emphasizes the significant characteristics of bladder mucinous adenocarcinoma, such as the sequence of tumor spread, the propensity for preliminary diagnostic errors, the microscopic pattern, and the significance of immunohistochemistry for defining its primary root from the bladder and selecting the most suitable intervention from the start.

A model for predicting overall survival in bladder cancer patients with signet ring cell carcinoma: a population-based study

IntroductionThis study is to examine the predictors of survival and to construct a nomogram for predicting the overall survival (OS) of primary bladder signet ring cell carcinoma (SRCC) patients based on the analysis of the Surveillance, Epidemiology, and End Results (SEER) database.MethodsA total of 219 eligible patients diagnosed with SRCC were analyzed using the 2004–2015 data from SEER database. Univariate and multivariate Cox regression were used to determine independent prognostic factors, followed by development of a nomogram based on the multivariate Cox regression models. The consistency index (C-index), receiver operating characteristic (ROC) curve, and calibration curve were used to validate the prognostic nomogram.ResultsThe nomograms indicated appreciable accuracy in predicting the OS, with C-index of 0.771 and 0.715, respectively. The area under the curve (AUC) of the nomogram was 0.713 for 1 year, 0.742 for 3 years, and 0.776 for 5 years in the training set, while was 0.730 for 1 year, 0.727 for 3 years, and 0.697 for 5 years in the validation set. The calibration curves revealed satisfactory consistency between the prediction of deviation correction and ideal reference line.ConclusionsThe prognostic nomogram developed in the analytical data of SEER it provided high accuracy and reliability in predicting the survival outcomes of primary bladder SRCC patients and could be used to comprehensively assess the risk of SRCC. Moreover, they could enable clinicians to make more precise treatment decisions for primary bladder SRCC patients.

Clinicopathological Characteristics and Prognostic Factors of Primary Bladder Signet Ring Cell Carcinoma

Introduction The aim of this study is to examine the treatment pattern and predictors of long-term survival of patients with primary signet ring cell carcinoma (PSRCC) of the urinary bladder based on the analysis of the SEER database. Methods The 3-year and 5-year overall survival (OS) and cancer-specific survival (CSS) were calculated using the Kaplan–Meier method. Then, we compared the CSS curves by the log-rank test. The independent risk factors were determined using univariate and multivariate Cox regression. Results The 3-year OS and CSS rates for PSRCC of the bladder were 25.3% and 33.3%. The 5-year OS and CSS rates for the entire cohort were 16.4% and 25.2%. The CSS rates, respectively, were 0, 25.0, 66.7, 33.2, 42.4, and 31.7% at 3 years and 0, 25.0, 34.3, 24.1, 27.2, and 31.7% at 5 years for none, transurethral resection of the bladder (TURB), partial cystectomy, radical cystectomy with reconstruction, pelvic exenteration, and other surgeries (P = 0.001). Multivariate analyses showed independent risk factors only including T stage, M stage, lymph node removal, and surgical approach. Conclusions T stage, M stage, lymph node removal, and surgical approach are independent risk factors of PSRCC of the urinary bladder. TURB and radical cystectomy with reconstruction appear to provide a better outcome.

Surgery improves survival in bladder signet-ring cell carcinoma-a population-based study.

Objectives:The purpose of this study is to determine the therapeutic value of surgery in individuals with urinary bladder signet ring cell carcinoma (SRCC). Surgery has not been examined as a prognostic factor for urinary bladder cancer (SRCC).Materials and Methods:Using the Surveillance, Epidemiology, and End Results program (SEER), patients with urinary bladder SRCC who presented from 1975 to 2018 were included in a retrospective study. The effect of surgical therapy on cause-specific survival (CSS) and overall survival (OS) was examined using univariate and multivariate Cox regression models. We subdivided 595 patients with SRCC into 2 groups, as follows: 496 who underwent surgery; and 99 who did not undergo surgery.Results:Males had high predominance in all cases in both groups (p = 0.04). Moderate and poor differentiation (III–IV) were observed in the majority of patients who underwent surgery (77.2 vs 58.6, p ⩽ 0.001) and had no insurance (p ⩽ 0.001). By using KM, the OS and CSS of the surgery group were found to be significantly better than those of the non-surgery group (p = 0.001,%) after adjusting for the variables of age, race, sex, primary site, grade, stage, lymph node removal, chemotherapy record, radiotherapy record, insurance, and marital status in the multivariate Cox proportional hazard model (hazard ratio [HR]= 0. 592; 95% confidence interval [CI] = 0.449–0.782; p = 0.0001). In comparison with chemotherapy and radiation, which resulted in poorer survival rates, surgery considerably improved survival outcomes in urinary bladder SRCC. The nomogram prediction model was built with C-index values of 0.70 and 73 for OS and CSS prediction, respectively. AUC in OS values were 0.77, 0.76, and 0.74, whereas AUC in CSS were 0.83, 0.80, and 0.79 for the 1-, 3-, and 5-year survival nomograms, respectively.Conclusion:Surgery was a significant independent predictor of bladder SRCC survival. Patients who underwent surgery had higher CSS and OS than people who did not undergo surgery. Surgery also led to better survival than the combination of the different treatment modalities.

Signet-Ring Cell Carcinoma of the Urinary Bladder: A Review and Update

Signet-Ring Cell Carcinoma of the Urinary Bladder: A Review and Update

Survival in signet ring cell carcinoma varies based on primary tumor location: a Surveillance, Epidemiology, and End Results database analysis

ABSTRACTBackground: The aim of this study was to investigate the survival of patients with signet ring cell carcinoma (SRCC) based on primary tumor location.Methods: Patient data were obtained from the Surveillance, Epidemiology, and End Results database (1988–2012) with ≥200 cases per tumor location. Cox regression analysis was used to investigate prognostic factors of cause-specific survival (CSS).Results: We identified 24,171 patients. Of the patients, 63.4% had gastric SRCC, followed by colon (18.2%), esophageal (5.0%), rectal (3.5%), lung (3.1%), pancreatic (1.8%), breast (1.5%), bladder (1.3%), small intestine (1.1%), and gallbladder SRCC (1.0%). The 5-year CSS was 22.1%, 69.0%, 33.2%, 28.1%, 24.8%, 16.1%, 13.6%, 12.6%, 11.0%, 6.4% in patients with gastric, breast, colon, rectum, bladder, small intestine, esophageal, gallbladder, lung, and pancreatic SRCC, respectively (P < 0.001). Multivariate analyses showed that the primary tumor location was an independent prognostic factor of survival. Patients with lung, small intestine, and bladder SRCC had a comparable CSS to gastric SRCC, while breast and colorectal SRCC had better survival than gastric SRCC. Esophageal, gallbladder, and pancreatic SRCC were significantly associated with poor CSS compared with gastric SRCC.Conclusion: Our study suggests a major difference in survival of SRCC based on the primary tumor locations.

Signet-Ring Cell Gastric Carcinoma Metastatic to Bladder

Bladder Signet-Ring Cell Carcinoma (SRCC) is extremely rare. It is most often primary, but metastatic disease is described in a few cases in literature. Herein we describe a case of primary SRCC of the stomach with metastasis to the bladder that did not have the chance to receive treatment and passed away due to tumor aggressiveness. We also reviewed the literature and discussed the etiology, prognosis and treatment of bladder SRCC.

The impact of signet-ring cell carcinoma histology on bladder cancer outcome

Signet-ring cell carcinoma (SRCC) of the urinary bladder is a rare entity. No previous studies have directly compared the cancer-specific survival of patients with SRCC to patients with urothelial carcinoma (UC) of the urinary bladder. Patients with diagnosis of urinary bladder SRCC and UC were identified in the Surveillance, epidemiology, and end results program (SEER) (2001-2004). Demographic of patients and clinical characteristics at diagnosis were compared. Differences in cancer-specific survival were compared using univariate and multivariate analysis. A total of 103 patients with SRCC and 14,648 patients with UC were indentified. Patients with SRCC were younger (P < 0.001), more commonly presented with higher-grade histology (P < 0.001) and advanced stage disease (P < 0.001), in comparison with patients with UC. The 3-year cancer-specific survival rate was 67.0% for patients with UC and 33.2% for SRCC. On multivariate analysis, there was an increased mortality risk in patients with SRCC versus UC (HR 1.49, 95% CI 1.11-2.00, P < 0.01). Even after adjusting for demographic, surgical, and pathological factors, cancer-specific survival rate was significantly worse in patients with SRCC compared to UC. Further research into the biology of this rare tumor is required to explain these results.

Primary Signet-ring Cell Carcinoma of the Urinary Bladder

To perform a comprehensive review and analysis of the clinical characteristics of primary signet-ring cell carcinoma of the bladder cases reported in Japan. Primary signet-ring cell carcinoma of the bladder is a rare condition. To date, the largest case series conducted for this condition includes only 11 cases. A search of published data was performed using the key words, "signet ring cell" and "urinary bladder." The Ichusi, which is the largest medical database in Japan, and the PubMed databases were searched. All articles reported from Japanese institutions were reviewed, regardless of their language. Overall, we identified 131 titles reported between 1981 and 2008. Meeting abstracts were excluded, but the unpublished cases managed at our institution were included. In all, 54 cases were comprehensively reviewed and analyzed. The median age at diagnosis was 61.2 years with male dominance (2:1). Among the selected cases, 46% had stage IV tumors. The overall survival rate at 2 years was 43%. However, none of the patients with stage IV disease at diagnosis were alive at 2 years. Multivariate analysis revealed that tumor stage and elevated carcinoembryonic antigen levels were significant prognostic factors. Of the 8 patients who were followed up for > 2 years and showed no evidence of recurrence, 7 were treated by either radical or partial cystectomy. Although the overall prognosis of this condition is poor, it is still dependent on the tumor stage at diagnosis. With early diagnosis and intervention, it may be possible to achieve long-term survival.

Primary Signet Ring Cell Carcinoma of the Urinary Bladder

188 Primary Signet Ring Cell Carcinoma of the Urinary Bladder Sunghwan Jung, Soojin Jung, Kweonsik Min, Jae-il Chung, Sunghyup Choi, Dongil Kang From the Departments of Urology and Pathology, Pusan Paik Hospital, Inje University College of Medicine, Paik Institute for Clinical Research, Busan, Korea Primary signet ring cell carcinoma of the urinary bladder is a relatively rare histological variant of mucus-producing adenocarcinoma usually of poor prognosis. We report two cases of primary bladder signet ring carcinoma. The first patient underwent a radical cystectomy with ileal conduit (pT3bN1M0), radiotherapy, and chemotherapy (M-VAC regimen) and subsequently expired 37 months after surgery. The other was initially diagnosed with peritoneal metastasis from the primary bladder signet ring cell carcinoma and was treated with partial cystectomy (pT3bNOM1). Postoperative adjuvant therapy was not done because of patient‘s refusal. (Korean J Urol 2009;50:188-191) 󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏

Primary Bladder Signet Ring Cell Carcinoma Extended to Prostate

49세 남자환자가 2개월 전 시작된 육안적 혈뇨, 요절박, 배뇨통을 주소로 내원하였다. 환자는 개인병원에서 치료 후 증상의 호전이 없어 본원으로 전원되었고, 과거력과 신 체검사에서 특이사항은 없었다. 요검사에서 적혈구가 현미 경 시야의 반에서 보였고, 소변세포검사에서 비정형세포가 관찰되었다. 방광경검사에서 전립선요도 근위부에 1cm 정 도의 base가 넓은 비유두상의 종양이 관찰되었고, 방광 점 막은 전반적으로 충혈된 소견이었다. 방광암 의심하에 경요도방광암절제술 후 다발성 방광 조 직검사를 시행하였다. 조직검사에서 방광은 모두 만성염증 소견이었고, 전립선요도부위의 종양은 전립선의 실질까지 침범한 반지세포암종으로 진단되었다 (Fig. 1). 병기를 결정 하기 위한 복부컴퓨터단층촬영에서는 좌측 방광기저부의 비후와 전반적으로 방광벽이 두꺼워 보였고 림프절이나 원 격전이는 없었다 (Fig. 2). 위내시경을 포함한 소화기계 검 사에서 이상소견은 없었다. 이상에서 전립선에서 기원한 반지세포암종으로 생각하고, 근치적 후치골전립선절제술 을 계획하였다. 수술장에서 전립선절제 후 요도방광문합술 을 위해 방광경부를 만져보았을 때 방광경부 3시 방향에 전립선을 침범한 방광의 원발성 반지세포암종

Colon and gastric metastases from a primary signet-ring cell carcinoma of the urinary bladder

Signet-ring cell carcinoma is a relatively rare neoplasm that rarely occurs in the urinary bladder. We report a case of a 60-year-old man who presented with gross haematuria. Cystoscopy revealed a white sessile tumour of the anterior bladder wall. The histological diagnosis showed a primary signet-ring cell carcinoma of the bladder (T3bN0M0). Eighteen months after radical cystectomy, the patient developed colon and stomach metastases. This case represents the first description of a primary signet-ring cell carcinoma of the urinary bladder with gastrointestinal metastases.

Primary Signet Ring Cell Carcinoma of Bladder - A Case Report and Review of the Literature

Signet ring cell carcinoma is a rare variant of primary adenocarcinoma of the urinary bladder. Its histologic feature is a high mucin content in the cytoplasma; this compresses the nuclei to one side and brings about signet-ring appearance. The clinical course is fatally fulminant with diffuse invasion and early metastasis. This report concerns a 70-year old female who complained of difficulty in urination and with urinary retention. The image studies, including ultrasound, IVU (intravenous urography) and CT (computerized tomography) scan, showed a tumor mass over the bladder base eith the appearance of indenting prostate. Radical surgery (anterior exenteration) followed by adjuvant chemotherapy was performed. The final pathologic diagnosis was non-urachal, pure, invasive signet wing cell carcinoma of bladder with sgage P4N2MO. The patient remained well during a six-month follow-up. The literature is reviewed.

Primary signet-ring cell carcinoma of the urinary bladder

An unusual case of the signet-ring cell carcinoma of the bladder was reported. A 62-year-old Japanese male had a three-month history of intermittent, painless and gross hematuria. He was found to have a small egg-sized bladder tumor near the right ureteral orifice. A cytologic diagnosis of signet-ring cell carcinoma was made on a bladder washing and was confirmed by cytoscopic biopsy and surgical specimens.

Signet-ring cell carcinoma of the urinary bladder primary presentation as a Krukenberg tumor

A 34-year-old female presented with a right ovarian Krukenberg tumor, which initially was thought to be a granulosa cell tumor. Eight months later, necropsy revealed a primary signet-ring cell carcinoma (SRCC) of the urinary bladder. When occurring in females, this rare bladder tumor often exhibits ovarian metastases. This case appears to be the first reported example of a signet-ring cell carcinoma of the bladder presenting as a Krukenberg tumor.