Blacks Research Articles

Experiences of Discrimination and Alcohol Involvement Among Young Adults at the Intersection of Race/Ethnicity and Gender.

Although discrimination is an important social determinant of alcohol involvement, there is a dearth of research testing these associations across race/ethnicity and gender. This is an important research gap given that experiences of discrimination and therefore links with alcohol involvement may vary as a function race/ethnicity and gender intersectional identities. We tested for measurement invariance in discrimination and alcohol involvement and examined group differences in means and covariances. The sample consisted of n = 1187 young adults (ages 18-26; n = 193 Black women, n = 209 Latina women, n = 186 White women, n = 198 Black men, n = 203 Latino men, and n = 198 White men). We found evidence for differential item functioning for discrimination and alcohol involvement that violated assumptions needed to make manifest between-group comparisons. To model the source and degree of differential item functioning, we used partial measurement invariance and dropped a discrimination item that did not reliably overlap with the latent factor for White women. After accounting for differential item functioning, Black women and men reported the highest discrimination, followed by Latinx women and men, and then White women and men. White women reported the most alcohol involvement, followed by White men, Latina women, Latino men, Black men, and Black women. Discrimination and alcohol involvement were positively associated for all groups except White women, though effect sizes varied with Black men exhibiting the largest effect. An intersectionally valid understanding of discrimination and alcohol involvement may necessitate statistical approaches that can test for (and model) differential item functioning prior to making between-group quantitative comparisons.

Closing the Dissemination Gap: Accessible Toolkits for the Rapid Replication of Evidence-Informed Interventions to Improve Health Outcomes Among People with HIV.

Despite advances in HIV care and treatment in the U.S., disparities in outcomes along the HIV care continuum persist. The widespread replication of effective and sustainable interventions that prioritize the engagement of underserved populations has been identified as a promising path to ending the HIV epidemic in the U.S. Intervention dissemination products, however, rarely provide the comprehensive and accessible information needed to replicate interventions within community settings. To bridge the divide between research and community-based implementation, the Using Evidence-informed Interventions to Improve Health Outcomes among People Living with HIV (E2i) initiative-grounded in the HIV/AIDS Bureau Implementation Science Framework-created a suite of tools to promote the rapid replication of interventions focused on transgender women, Black men who have sex with men, behavioral health integration, and identifying and addressing trauma. The resulting dissemination products are detailed and digestible multimedia toolkits that follow adult learning theory principles and align with the Template for Intervention Description and Replication criteria for adapting non-pharmacological interventions. Each E2i toolkit consists of five components: implementation guides, narrative videos of site implementation, best practice demonstration videos, interactive learning modules, and recruitment posters and brochures. Over 2 years (2022-2024), the E2i toolkit webpages amassed 7703 unique users and 17,666 pageviews. These toolkits can serve as a blueprint for designing comprehensive and accessible dissemination products for replication of HIV interventions in care settings. Dissemination products that bridge the gap between intervention research and replication in community settings are a crucial missing tool for ending the HIV epidemic.

Prenatal Substance Exposure and Infant Discharge Placement: Results From the ACT NOW Study.

It is critical that researchers gather evidence of factors that identify infants at risk of out-of-home placement based on types of substance exposures and demographic characteristics. This study applied a validated medical record data extraction tool on data derived from a multi-site (N = 30) pediatric clinical trials network (ISPCTN) study of Neonatal Opioid Withdrawal (ACT NOW study). Participants included 1808 birthing parent-infant dyads with documented NOWS scoring or prenatal opioid exposure. Non-Hispanic White pregnant persons comprised the largest proportion of the sample (69.8%), followed by Non-Hispanic Black (11.6%), Non-Hispanic Multiracial and Other race (8.5%), and Hispanic (6.2%). Most notably, infant prenatal substance exposure across alcohol, cocaine, meth/amphetamine, and opioids, had the lowest possibility of discharging to parent(s). Additionally, latent class analysis identified distinct classes of substance use during pregnancy that were associated with different probabilities of discharging to parent(s). Specifically, less than half of infants (47%-49%) in the Poly-use and Meth/amphetamine classes were discharged to their parent(s). Severity of infant withdrawal symptoms influenced placement decisions within the Poly-use and Prescription Opioid classes. Findings can inform standard practices for increasing support for pregnant persons and substance-exposed infants including identification, subsequent referrals, communication with Child Protective Services, and plans of safe care.

White NIMBYism and diversity close to home

AbstractObjectiveWe use a survey experiment to study what explains white “not in my backyard” opposition (NIMBYism) to dense and affordable housing—racial threat, material self‐interest, or both.MethodsIn a survey experiment on white U.S. respondents, we vary the presence of a racial prime about black and Latinx community organizations and the proximity of the housing development to the subject's home. We then measure levels of support for a proposed hypothetical housing development, willingness to take political action in support of or opposition to the development, and support for a number of housing‐related and redistributive policies.ResultsWe find that a racial threat, a material self‐interest threat, and a combined racial and material self‐interest threat decrease support for a proposed housing development. These effects are moderated by racial resentment, ideology, and partisanship such that the effects of the treatments are primarily driven by Republicans, conservatives, and the highly racially resentful. These groups are more threatened than others by either Latinx and black people moving in, the development being in their own neighborhood, or both.ConclusionThese findings indicate that racial and material perceived threats play important and interlocking roles in white Americans’ resistance to multifamily housing being built. In a context where local political institutions empower an unrepresentative group of disproportionately white, economically privileged neighbors to mount opposition to dense housing, it is important to understand how white opposition to new dense housing is shaped by racial and financial concerns.

American Arcadia? The Shift of the Homoerotic Gaze in Herbert List’s Work

The German photographer Herbert List (1903–75) is well known for his pictures from the Mediterranean, metaphysical still lives and portraits of young men. The latter, in particular, have garnered continuous attention due to their beauty and as examples of homosexual aesthetics in prewar and postwar Europe. A lesser-known body of work are his photographs taken in the Caribbean in 1957, including portraits of Black men. This article sheds light on List’s different homoerotic images by situating them in their art historical as well as local context. First, in an analysis of his Oriental and Orientalist representations of young men in Tunisia, I delineate his expansion of classical Greco-Roman tropes. Second, I contrast these images with List’s portraits of people of colour in the Caribbean and his critique of their historical exploitation and current living situation. In both contexts, List is complicit with as well as in contradiction to the power dynamics of European imperialism, and both follows and digresses from white European visual traditions. This analysis expands current scholarship by taking into consideration the issues of race, class and postcolonialism and their impact on the representation of bodies of colour.

Conceptualizing White Allyship among Undergraduate Students in the United States

ABSTRACT Colonialism in the U.S. has embedded anti-Blackness in social institutions, including but not limited to those of higher education. Preliminary research indicates that white allyship, or white people’s efforts to dismantle racism by advocating for and partnering with People of Color, is protective and beneficial to Black communities. However, little work has sought to clarify conceptualizations of white allyship – especially comparing the perspectives of Black and white students. To address this, the present study recruited 24 undergraduate students (12 Black, 12 white) to participate in semi-structured interviews focused on white allyship. Data were systematically transcribed, then coded using thematic analysis. Results indicated that Black and white students have somewhat similar understandings of allyship spanning from emotional support to actively resisting oppression; however, Black students generally conceptualized ally behaviors as involving more risk-taking. These data lend support to what Black Activists have been urging for years: emotional support and self-education are important ally behaviors, yet combating anti-Blackness also involves disrupting the systems that perpetuate it. Findings have implications for vested partners in education, institutions, and researchers.

CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2017-2021.

The Central Brain Tumor Registry of the United States (CBTRUS), in collaboration with the Centers for Disease Control and Prevention and the National Cancer Institute, is the largest population-based registry focused exclusively on primary brain and other central nervous system (CNS) tumors in the United States (US) and represents the entire US population. This report contains the most up-to-date population-based data on primary brain tumors available and supersedes all previous reports in terms of completeness and accuracy. All rates are age-adjusted using the 2000 US standard population and presented per 100,000 population. Between 2017 and 2021, the average annual age-adjusted incidence rate (AAAIR) of all primary malignant and non-malignant brain and other CNS tumors was 25.34 per 100,000 population (malignant AAAIR=6.89 and non-malignant AAAIR=18.46). This overall rate was higher in females compared to males (28.77 versus 21.78 per 100,000) and non-Hispanic Black persons compared to persons who were non-Hispanic White (26.60 versus 25.72 per 100,000), non-Hispanic American Indian/Alaska Native (23.48 per 100,000), non-Hispanic Asian or Pacific Islander (19.86 per 100,000), and Hispanic persons of all races (22.37 per 100,000). Gliomas accounted for 22.9% of all tumors. The most commonly occurring malignant brain and other CNS histopathology was glioblastoma (13.9% of all tumors and 51.5% of all malignant tumors), and the most common predominantly non-malignant histopathology was meningioma (41.7% of all tumors and 56.8% of all non-malignant tumors). Glioblastomas were more common in males, and meningiomas were more common in females. In children and adolescents (ages 0-19 years), the incidence rate of all primary brain and other CNS tumors was 6.02 per 100,000 population. There were 87,053 deaths attributed to malignant brain and other CNS tumors between 2017 and 2021. This represents an average annual mortality rate of 4.41 per 100,000 population and an average of 17,411 deaths per year. The five-year relative survival rate following diagnosis of a malignant brain or other CNS tumor was 35.7%. For a non-malignant brain or other CNS tumor the five-year relative survival rate was 92.0%.

9265 Racial/Ethnical Differences in Classic and 11-Oxygenated Androgens

Abstract Disclosure: C. Lee: None. R.J. Auchus: None. J. McDonald: None. J. Rege: None. W.E. Rainey: None. A.F. Turcu: None. Background: Malignancies modulated by sex-steroids, such as prostate and breast cancer, as well as disorders of androgen excess, like polycystic ovary syndrome, display prevalence and/or phenotype differences across races/ethnicities. Such differences have been attributed, in part, to testosterone (T). A set of adrenal-derived 11-oxygenated C19 steroids (11-oxyandrogens) has emerged as relevant to several androgen-dependent pathologies. Classic and 11-oxyandrogens are impacted differently by age and adiposity. Data on race and ethnic variations in 11-oxyandrogen concentrations are lacking. Setting and Participants: Participants in the population-based, multiethnic cohort of the Dallas Heart Study, phase 2. Measurements: T, androstenedione (A4), 11β-hydroxyandrostenedione (11OHA4), 11β-ketoandrostenedione (11KA4), 11-hydroxytosterone (11OHT), and 11-ketotestosterone (11KT) were quantified simultaneously in peripheral blood using liquid chromatography-tandem mass spectrometry. Steroids were compared across races stratified by gender, and adjusted for age and BMI, using linear mixed models in SAS (NC, USA). Results: Of the 1966 participants included, 1137 (57.8%) were women, 49% were non-Hispanic Black, 35% non-Hispanic White, and 14% Hispanic. The mean age of study participants was 51.3 +/- 10.3 years, and mean BMI was 31.0 +/- 7.1 kg/m2. Compared to White individuals of similar age and BMI, 11KT concentrations were higher in both Black women (β = 3.5 +/- 1.2, p = 0.004), and Black men (β = 5.8 +/- 1.9, p = 0.002). The immediate precursor of 11KT, 11KA4, displayed higher concentrations in Black vs. White men (β = 2.9+/- 0.7, p < 0.0001), with similar trends in women (β = 3.0 +/- 1.6, p = 0.056). The weak androgen 11OHT was higher in Black vs. White women (β = 3.0 +/- 0.91, p = 0.0009), but did not differ across races in men. Compared to White individuals of the corresponding gender, age- and BMI-adjusted 11OHA4 concentrations were higher in Hispanic women (β = 10.8 +/- 5.4, p = 0.043), and in Black men (β = 20.9 +/- 4.8, p < 0.0001). The classic androgen T was higher in Black women and men (β = 3.7 +/- 1.4 and β = 41.5 +/- 14.7, respectively, p < 0.01 for both), as well as in Hispanic men (β = 46.6 +/- 21.8, p = 0.03) compared to their White counterparts with similar age and BMI. A4 concentrations were similar across races. Conclusions: The bioactive androgens 11KT and T were higher in Black women and men compared to White individuals with similar age and BMI. Conversely, in Hispanic men, only T was higher compared to White men. In addition to T, 11KT might also contribute to disproportionately high prevalence of androgen-related pathologies in Black individuals. Acknowledgements: This work was supported by grant R01AG08051601 from the National Institute of Aging, and, in part, by grant UL1TR001105 from the National Center for Advancing Translational Science, National Institutes of Health. Presentation: 6/1/2024

6676 Exposure to Neighborhood Violence Rewires Glucocorticoid Receptor Binding and Drives Proliferation and Invasiveness in Lung Tumor Samples

Abstract Disclosure: H. Heath: None. J. Yoo: None. S. Akter: None. A. Jain: None. V. Sharma: None. H. McGee: None. A. Soliman: None. A. Mohamed: None. A.K. Matthews: None. R. Winn: None. Z. Madak Erdogan: None. S. Kim: None. Background: Despite the lower rates and frequency of smoking, Black men experience a higher incidence of lung cancer compared to white men. This health disparity is even more prevalent in Black men from Chicago, suggesting local neighborhood factors impacting tumorigenesis. Preliminary data indicate that, compared to white men, Black men are more likely to reside in neighborhoods with high levels of violence and have elevated levels of hair cortisol. Objective: To understand the link between lung tumorigenesis and exposure to neighborhood violence, our objective is to investigate the chromatin recruitment of the receptor for cortisol, called the glucocorticoid receptor (GR), and to correlate this recruitment with target gene expression levels. Methods: Utilizing CUT & RUN, we identified the gene binding sites of GR using 15 lung tumor and corresponding healthy tissue samples from lung cancer patients living in Chicago. GR recruitment to chromatin was correlated with the neighborhood homicide rate obtained using patients’ zip codes. Spatial transcriptome profiles for these 15 lung tumor samples were obtained from the Space Ranger pipeline and gene expression hot spots of GR target genes were visualized using Loupe Browser (10x Genomics). Results: GR recruitment to regulatory regions of chromatin increases with greater zip code level violence rates. In patients from high violence neighborhoods, tumor samples had higher magnitude of binding compared to normal neighboring tissue. In tumor samples from patients living in high violence compared to low violence neighborhoods, GR binding is seen in genes that are associated with increased tumor aggressiveness. Hot-spot analysis of these genes found strong co-expression of genes associated with proliferation and invasion in samples from high violence but not low violence neighborhoods. Conclusion: Exposure to neighborhood violence may impact tumor biology via increased GR recruitment to genes associated with proliferation and invasion. Presentation: 6/2/2024

Evaluation of a National Sample of 16,671 Pediatric Burn Admissions: Identifying Predictors of Non-accidental Pediatric Burns

BackgroundBurn injuries remain one of the leading causes of injury and death in children. Studies have demonstrated a higher mortality for pediatric burns associated with non-accidental injury. Using data from a burn registry, our study aimed to discern potential factors associated with non-accidental burn injuries. MethodsWe utilized the American Burn Association database from 2016 to 2018, which collects data from over one hundred burn centers across the United States, to evaluate a large pediatric burn population. Patients aged ≤14 years were analyzed. The population was then divided into suspected non-accidental versus accidental burn injuries. A multivariable logistic regression model was utilized to evaluate for predictors of burn injuries. Additional models were used to assess the relationship between suspected non-accidental burn injury and mortality, intensive care unit (ICU) stay, and hospital length of stay. Results16,671 pediatric patients were included. Of those, 1228 (7.4%) patients suffered non-accidental burn injury. A majority of children who sustained non-accidental burn injury were younger, non-white, and sustained scald burns. The regression model demonstrated predictors for non-accidental burn injuries included younger age, Black race, chemical/corrosion burns, government insurance, and increased total body surface area (TBSA) burn. Overall mortality for the population was 0.5%. ConclusionThis evaluation of a national burn registry reveals differences in pediatric patients sustaining non-accidental burns compared to accidental burns. The findings in this study identify pediatric populations at risk for suspected non-accidental burn injuries which may assist in preparing the families for expectations after admission for a burn injury. Level of EvidenceIII.

Living less safely through the pandemic in England for people with serious mental and physical health conditions: qualitative interviews with service users and carers of Black African, Caribbean, and South-Asian descent.

COVID-19 Ethnic Inequalities in Mental health and Multimorbidities (COVEIMM) is a mixed methods study to explore whether COVID-19 exacerbated ethnic health inequalities in adults with serious mental and physical health conditions. We analysed data from electronic health records for England and conducted interviews in Birmingham and Solihull, Manchester, and South London. Sites were selected because they were pilot sites for the Patient and Carer Race Equality Framework being introduced by NHS England to tackle race inequalities in mental health. Prior to the pandemic people in England with severe mental illnesses (SMIs) faced an 11-17-year reduction in life expectancy, mostly due to preventable, long-term, physical health conditions. During the pandemic there was a marked increase in deaths of those living with an SMI. This qualitative interview study aimed to understand the reasons underlying ethnic inequalities in mortality and service use during the COVID-19 pandemic for adult service users and carers of Black African, Black Caribbean, Indian, Pakistani, and Bangladeshi backgrounds living with serious multiple long-term mental and physical health conditions. We took a participatory action research approach and qualitative interviews undertaken by experts-by-experience and university researchers Participants were purposively sampled by ethnicity, diagnoses, and comorbidities across three geographically distinct sites in England. Transcriptions were coded inductively and deductively and analysed thematically. Findings indicated multiple points along primary and secondary health pathways for mental and physical health that have the potential to exacerbate the unjust gap in mortality that exists for Black and Asian people with SMIs. Issues such as timely access to care (face-to-face and remote), being treated in a culturally appropriate manner with empathy, dignity and respect, and being able to use services without experiencing undue force, racism or other forms of intersectional discrimination were important themes arising from interviews. These poor experiences create systemic and enduring healthcare harms for racialised groups with SMIs that need to be addressed. Our findings suggest a need to address these, not only in mental health providers, but across the whole health and care system and a need to ensure more equitable healthcare partnerships with service users, carers, and communities from racialised backgrounds who are often excluded.

Bioarchaeological Approaches to African Diasporas in the Twenty-First Century: Intercontinental and Global Legacies of Displacement

ABSTRACT Bioarchaeological research offers a window into health and life experiences in the past, including the biocultural dimensions of social identities and structural inequalities experienced by enslaved and free Afro-descendants across the African diaspora. Given the long history of descendant communities and advocates contesting the authority of institutions to curate human remains in perpetuity, critical dialogues over the past several decades have stimulated new directions in the discipline of African diaspora bioarchaeology alongside increased engagement with Black scholarship and community and client-based collaborations. We build upon previous discussions and critiques to examine the current state of African diaspora bioarchaeology in global context in the early decades of the twenty-first century. We present a macro-level, chronological examination of published African diaspora and colonial African bioarchaeological research by region between 2001 and 2023 and conclude with a discussion of the current state of practices and engagement in the field and ethics of care.

Implications of Islamic Mahr (dower) and African Lobolo (bride-price) on Religious and Customary Marriages and the Rights of Muslim Women to Inherit in South Africa

Abstract The monogamous and polygynous customary marriages of indigenous Black Africans have been fully legally recognised in South Africa since 1998. The outcome of a June 2022 apex Constitutional Court judgment will finally result in monogamous and polygynous Muslim marriages (nikāḥ) being fully legally recognized and regulated by the State by 2024. Since this recognition does not include the Islamic law of succession (which will not pass constitutional muster because of half-share to women), when Muslims die intestate, the secular law is expected to apply. The payment of mahr (dower) by the groom to the bride (an important ingredient of a nikāḥ contract) is therefore an important alternative tool for augmenting the inheritance of Muslim women during their lifetime. A novel fatwā issued by local Black African ulama in August 2022 brought to light several challenges faced by African Muslims regarding the relation of nikāḥ marriages to distinctive African traditional marriage practices like the lobolo (“bride price”) paid by the groom to the bride’s father. This paper examines the implications of mahr and lobolo on religious and customary marriages and the rights of local Black African Muslim women to inherit in terms of religion and custom.

Representation of Racism and Anti-blackness in African-American Proverbs

Proverbs have captivated researchers worldwide, since they mirror how cultures portrait folks’ social lives. African American proverbs related to racism and anti-blackness, among them, are made use of to expose how the culture of the Western world in general and of America in particular view racial attitudes in these sayings. By exploiting four analytical tools of critical stylistics viewed in Jeffries’ model, thirty proverbs will be examined (exemplified by five proverbs) regarding their stylistic features and racial-related ideologies. This paper schemes into how Indians are stereotyped in these proverbs. Through exploiting the selected critical stylistic tools, it concludes that the proverbs examined either implicitly or explicitly express how black people are treated racially and inhumanely in everyday settings and in proverbs as well.

Remaining in the wake: towards an endarkened paradigm for critical studies of whiteness

ABSTRACT Critiquing how critical whiteness studies (CWS) in US education has strayed towards a predominant focus on how white people understand their relationship to whiteness and away from understanding how whiteness oppresses People of Colour, Matias and Boucher articulated a Black whiteness studies approach to the critical study of whiteness that eschews white epistemological standpoints, engages the works of Scholars of Colour and expands beyond a focus on developing white people’s racial consciousness. However, their articulation of a Black whiteness studies falls short of addressing Black communities’ specific racial positioning, the unique ways Black people suffer under whiteness and the situated knowledges of Black communities. In this paper, I theorise at the intersections of CWS, endarkened feminisms and afropessimsim to extend Matias and Boucher’s work to propose an endarkened paradigm for critical studies of whiteness.

Race- associated molecular differences in uterine serous carcinoma.

Endometrial cancer (EMCA) is the most common gynecologic malignancy, and new diagnoses are increasing in the United States. Black patients are more likely to present with advanced stage, be diagnosed with high-risk uterine serous carcinoma (USC) and die of their cancer. Patients with endometrial adenocarcinoma who received tumor FoundationOne CDx testing at our institution between January 2017 and August 2022 were identified. Genomic alterations, demographic and clinical characteristics were collected. Descriptive statistics and Fisher's exact test were used to analyze data. A total of 289 patients (29.4% Black and 52.6% White) with advanced or recurrent endometrial adenocarcinoma underwent FoundationOne CDx testing. USC comprised 26.3% (76 of 289) of tested tumors. Of USC tumors, 33 of 76 (44%) were of Black race. USC occurred more frequently in Black patients (33 of 85 [38.8%] Black patients compared to 30 of 152 [19.7%] White patients, p<0.05). Among USC, CCNE1 amplification occurred more frequently in Black patients than in White patients (12 of 33 [36.36%] vs 2 of 30 [6.67%], p<0.05) while PI3K/AKT/mTOR pathway mutations occurred less frequently (16 of 33 [48.5%] vs 26 of 33 [86.7%], p=0.17). Among patients with CCNE1 amplification 73.3% (11 of 15) progressed on or within 12 months of first-line platinum-based therapy. CCNE1 amplification had significantly shorter median overall survival (97.3 months vs 44.3; HR (95%CI): 7.1 (10.03, 59.4) p< 0.05). Black patients constituted 44% of patients with USC in our study and had an increased frequency of CCNE1 amplification. Patients whose tumors harbored CCNE1 amplification had shorter overall survival. Identifying actionable mutations in this high unmet need population is crucial to improving outcomes among Black patients with uterine malignancy. Development of new targeted-therapies will need to keep these alterations at the forefront as trials are being designed.

Hotep anti-Blackness: Misogynoir and queer exclusion in online conspiracy theorizing

Research suggests African Americans are more likely than Whites to support conspiracy theories, especially those related to the U.S. government. Locating the pedagogical practices of Black activists in the online hotep subculture, I use the concept of public pedagogy to understand how these activist influencers use social media to spread political messages in the public sphere. This essay situates hotep subculture as a conspiritualist project that uses Pan-Africanism, Afrocentricity, Black spirituality, and hip-hop culture to advance conspiracy theories among Black communities for consciousness-raising and economic independence. While hoteps have promulgated a pro-Black politic, their reliance on ethnonationalist homophobia and misogynoir promotes a form of erasure that is not only exclusionary and anti-Black but also reflects racial fears rooted in anxiety. This essay contributes to the growing literature on conspiritualism’s investment in white supremacy and the need for conspiritualist critiques to investigate how anti-Blackness shows up in discourses at the intersection of faith, spirituality, and global regimes of power. Drawing on the concepts of misogynoir and anti-Black heterotopias, Black gender and sexual minorities are framed within hotep discourse as subservient, deviant, and perilous to Black liberation.

The Relationship Between Racial Attitudes and Disordered Eating Behaviors in Black Men and Black Women.

Black individuals remain underrepresented in disordered eating research, despite evidence that both Black men and women present with disordered eating behaviors. Culturally-informed theoretical frameworks suggest that these behaviors may be linked to race-related sociocultural experiences, such as aspects of racial identity. While studies have focused on racial identity commitment, the association between attitudes toward one's racial identity and disordered eating remains underexplored. The present study examines whether positive attitudes toward one's Blackness and Black culture are associated with disordered eating. In a cross-sectional online sample of Black men and women (N = 458), we measured self-reported attitudes toward Blackness (i.e., centrality and private regard) and disordered eating behaviors (i.e., purging, binge eating, excessive exercise, and drive for thinness). In pre-registered linear regression models, private regard was negatively associated with purging and binge eating. Across all models, centrality was not associated with disordered eating. On average, Black women reported greater drive for thinness whereas Black men reported higher excessive exercise scores. This is the first study to demonstrate associations between racial attitudes and disordered eating among Black men and women. Our findings affirm unique correlates of disordered eating among Black people and suggest that positive attitudes toward one's Blackness and Black culture may be a protective factor against the development of disordered eating.

OTHR-12 INCIDENCE, CLINICAL PRESENTATION, MANAGEMENT AND ONE- AND TWO-YEAR SURVIVAL OF PATIENTS WITH MEDULLOBLASTOMA AT INKOSI ALBERT LUTHULI CENTRAL HOSPITAL, KWAZULU NATAL PROVINCE: A TEN YEAR REVIEW

Abstract OBJECTIVE Epidemiology, clinical presentation, stage and multidisciplinary treatment modalities for Medulloblastoma (Mb) at Inkosi Albert Luthuli Central Hospital (IALCH) for the 10 year period from 2003 to 2012. It also evaluated the 1 and 2 year survival rate. Methodology: Single center- retrospective study of Mb patients below the age of 18 years in a low and middle income country (LMIC) setting. RESULTS The 30 patients included in the study, median age was 9 years. Male to female ratio of 1.3:1. 70% were black race. Average incidence was 14 per 1000 children years. Headache was most common symptom in 70% of the patients. Majority presented with advanced non metastatic disease (T3b). All patients had shunt insertion prior to debulking surgery and 60% had gross total resection. More than half of the cases had reduced dose irradiation (30.6Gy) to the cranial and spinal compared to 36% who had 36Gy. 96% received concurrent vincristine with radiotherapy. 89.7% received adjuvant chemotherapy and 82.8% completed 6 cycles. There was not enough data to determine any trends in the different modalities of treatment offered over the period of 10 years. One year survival rate was 83.33% [95% CI 64.55; 93.70%] and probability of surviving two years was 80.00% [95% CI 60.87%; 91.60%]. CONCLUSION Children present with advanced stages requiring multi-level surgeries. Dedicated multi-disciplinary approach to treatment conferred decent survival outcomes despite the advanced stages at presentation. Similar successes were reflected in the only other study on the subject in Cape Town in a 3 decade retrospective study between the years 1985-2005. These studies highlight the importance of implementing multidisciplinary team management in parallel with modern radiotherapy techniques to improve survival for children with medulloblastoma. Current training programs like Access to Care Capetown could further improve the outcome in countries establishing or transitioning to new radiotherapy techniques.

B-321 Enhancing Early Detection of Prostate Cancer Using PSA-Guided Screening in High-Risk Men Under 50

Abstract Background Prostate Cancer remains a significant global public health concern. It is the most common cancer and the second leading cause of cancer death among men in the United States. Current guidelines, including those by the USPSTF, ACS and ASCO offer varying recommendations on PSA screening. Present clinical practice, primarily targeting men aged 50-69. Our study aimed to assess the feasibility and validity of using PSA for targeted screening in men under 50 who are at high risk, enhancing early detection of prostate cancer. Methods This retrospective analysis utilized data from our hospital's prostate cancer screening program collected from 2022 to 2023, including104 individuals under 50. Participants were categorized based on PSA levels 4-10 ng/mL (n=71) and over10 ng/mL (n=33). We analyzed the number of cases diagnosed with prostate cancer and the correlation with PSA levels, Gleason Scores (GS), family history, and ethnicity/race. Results In the104 participants, 88 of them were diagnosed with prostate cancer, highlighting an 84.6% detection rate. Among PSA levels 4-10 ng/mL group, 36 out of 43 White or Caucasian and 13 out of 13 Black or African American men were identified as GS 6-10. In the group PSA over 10 ng/mL, 18 White or Caucasian and 6 Black or African American individuals with more aggressive disease (GS 6-10). Importantly, a substantial fraction of these cases had a first-degree relative with prostate cancer, emphasizing the influence of family history on PSA screening decision. Conclusions Our findings suggest that PSA-guided screening in men under 50 at high risk can enhance the early detection of prostate cancer. The significant presence of intermediate-risk prostate cancer (GS 6 or 7) in populations at higher risk due to ethnicity/race and family history. Our study highlights the potential benefits of revisiting current screening guidelines to lower the age threshold for high-risk populations.