Blacks Research Articles

West African Genetic Ancestry, Neighborhood Deprivation, and Prostate Cancer

Racial disparities in prostate cancer are likely the result of complex relationships between both socioeconomic and environmental factors captured by the neighborhood environment and genetic factors, including West African genetic ancestry. However, few studies have examined the combined role of neighborhood environment and genetic ancestry in developing lethal prostate cancer. To examine the interactions between West African genetic ancestry and neighborhood deprivation in modifying prostate cancer risk and mortality. This case-control study was conducted in the Greater Baltimore area. Participants included men of African and European descent (617 cases with prostate cancer, 852 controls without prostate cancer) enrolled between January 2005 and January 2016. Follow-up was performed through December 31, 2020, using the National Death Index. Analysis was conducted from August 2023 to January 2024. Included exposures were West African genetic ancestry, derived from large-scale genotyping, and neighborhood deprivation, defined using 2000 census-tract-level Neighborhood Deprivation Index (NDI) score. Outcomes of interest were prostate cancer and all-cause mortality. Among a total of 1469 participants (mean [SD] age, 64.96 [7.95] years), there were 736 self-identified Black and 733 White men, and the mean (range) proportion of West African genetic ancestry was 0.27 (0.04-0.84) among participants residing in areas with low levels of deprivation and 0.48 (0.07-0.83) among participants residing in areas with high levels of deprivation. Multivariable logistic regression analysis revealed a significant multiplicative interaction of West African genetic ancestry and neighborhood deprivation with the odds of a prostate cancer diagnosis (P for interaction = .02). Among individuals living in neighborhoods with high NDI scores, West African genetic ancestry was associated with increased odds of a prostate cancer diagnosis (age-adjusted odds ratio [OR], 1.98; 95% CI, 1.23-3.19). In contrast, West African genetic ancestry was associated with reduced odds of this diagnosis among individuals residing in areas with medium to low levels of deprivation (age-adjusted OR, 0.22; 95% CI, 0.11-0.44). There was no significant multiplicative interaction between West African genetic ancestry and neighborhood deprivation for all-cause mortality (P for interaction = .44). The positive association of neighborhood deprivation with prostate cancer was independent of West African genetic ancestry (age- and West African ancestry-adjusted OR, 1,70; 95% CI, 1.50-1.94). This case-control study of men with West African and European ancestry found that West African genetic ancestry was associated with increased odds of prostate cancer among males who resided in neighborhoods with high deprivation but lower odds in more affluent neighborhoods. Thus, neighborhood environments may play a critical role in defining how genetic ancestry modulates prostate cancer risk.

Proteinuria and albuminuria among a global primary CVD prevention cohort of PWH: prevalence and associated factors.

To determine baseline prevalence of proteinuria and albuminuria among REPRIEVE participants and evaluate associated risk factors. Cross sectional analysis of a baseline sample of participants from the REPRIEVE Trial. REPRIEVE is an international primary cardiovascular prevention RCT of pitavastatin calcium vs. placebo among PWH on antiretroviral therapy. A representative subset (2791 participants) had urine collected at study entry. Urine protein to creatinine ratios (uPCR) and albumin to creatinine ratios (uACR) were classified as normal, moderately increased and severely increased. These were dichotomized to Normal or Abnormal for log-binomial regression analysis. Demographic, cardiometabolic, and HIV-specific data were compared among those with normal versus abnormal results. Overall, median age 49 years, 41% female sex, 47% black or African American race, 36% had eGFR <90 mL/min/1.73 mm2. For uPCR, 27% had moderately or severely increased values. For uACR, 9% had moderately or severely increased values. In the fully adjusted model for proteinuria, female sex, older age, residence in sub-Saharan Africa or East Asia, lower BMI, lower CD4 cell count, and use of TDF were associated with abnormal values. In the fully adjusted model for albuminuria, a diagnosis of HTN was associated with abnormal values. Abnormal proteinuria and albuminuria remain common (27% and 9%) despite controlled HIV. Lower current CD4 count and TDF use were strongly associated with proteinuria. Certain modifiable comorbidities, including HTN and smoking, were associated with abnormal values. In PWH with preserved eGFR, urine measures identify subclinical kidney disease and afford the opportunity for intervention.

Pre-service mathematics teachers’ perceptions based on two differing mathematically underpinned debates

This study explores how pre-service mathematics teachers build alternative model simulations of real-world scenarios. Inclusion in the formal structures for wealth generation and accumulation is a fervently debated issue in South Africa. Share owning in companies listed on the Johannesburg Stock Exchange (JSE) in South Africa is one of many wealth-building tools. Related discussions evolved on the spread of share ownership among black and white citizens. Two mathematically motivated positions were reported in a newspaper. In one of their mathematics courses, prospective mathematics teachers were presented with the article and asked to reflect on it with the prompt 'Which of these two methods for determining the "number of Black South Africans holding shares on the JSE" would your group support?' Audio- and video-recorded data were collected and subjected to thematic analysis. The themes that emerged from the analysis were economic empowerment, authority of research and trustworthiness of information. The discussions reflected on the complexities and rationalities involved in decision-making of mathematically driven opposing positions on issues of social importance. The mathematically derived results of such issues will eventually be resolved in the political field. The findings revealed that building of alternative mathematical models by pre-service mathematics teachers begins with an explicit problem setting, followed by the development of mathematical models that included real-world problems.Contribution: This article contributes to pre-service mathematics teacher education by exploring how such teachers deal with the issue of critical engagement of mathematically based arguments, highlighted in the Curriculum Assessment and Policy Standards (CAPS) document for school mathematics.

Driving Under the Influence of Alcohol and Cannabis by Sexual Identity, Race, Ethnicity, and Gender: A Nationwide Analysis Using the 2016 to 2019 National Survey on Drug Use and Health.

Sexual minority populations experience higher rates of substance use and related problems, but little is known about their specific involvement in driving under the influence (DUI) of alcohol (DUIA) and cannabis (DUIC) incidents. Using data from the 2016 to 2019 National Survey on Drug Use and Health, we used logistic regression models to estimate the interactive effects of sexual identity, race/ethnicity, and gender on past-year DUIA among adults who used alcohol and DUIC among adults who used cannabis, accounting for covariates. Using model estimates and linear combinations, we calculated the predicted probabilities of each outcome and compared sexual identity differences within and across race/ethnicity and gender. With few exceptions, the predicted probabilities of DUIA and DUIC were significantly higher among sexual minority women than heterosexual women of similar race/ethnicity. The results were more variable among men with the probabilities of DUIA and DUIC being significantly higher for some groups of sexual minority men and some groups having probabilities equal to or lower than similar heterosexual men. Some of the largest sexual minority gaps in DUIA and DUIC were observed among Hispanic and Other lesbian women and Black gay men. Sexual minority individuals are more likely to report DUI than their heterosexual counterparts; however, the risk of DUI among sexual minority populations varies by racial/ethnic and gender subgroup. Our findings indicate the importance of applying an intersectional framework when addressing substance-use-related disparities and when designing effective DUI prevention interventions for sexual minority populations.

The immovable veil of black disability: an introduction to Black disability threat theory and its application to the school to prison nexus

ABSTRACT I propose a new theoretical framework that incorporates an intersecting analysis of Blackness and disability: Black disability threat theory. A major contribution of this theory is the notion that being visibly Black and visibly disabled causes moral panic to disabled and nondisabled populations belonging to any racial group including non-disabled Black American persons and disabled White American persons. Additionally, a broader category of intersectional theories has been applied and leveraged to learn more about inequities and how we might resolve them. Being obviously Black and obviously disabled excludes one from belonging to and fully participating in either the disability culture or the Black culture as we are accepted by neither. In society (and schools), these persons – those who wear a veil of both Blackness and disability – are categorized, considered, and treated as the most dangerous of all which typically results in negative life outcomes.

Championing Inclusivity: Underrepresentation of Women in African Academic Leadership and Scholarly Journal Management

Objectives – This study seeks to investigate the exclusion of women from the management of scholarly journals across East Swahili (Kenya, Uganda, Tanzania, South Sudan, Ethiopia, and Anglo-West Africa (Ghana, Nigeria, Sierra Leone, Liberia, Gambia) by delving into the implications of marginalization. Furthermore, the study aims to illuminate the often-overlooked experiences of black women, whose narratives are frequently overshadowed by those of black men or subsumed within the context of white women. Methods – By employing empirical evidence from African Journals Online (AJO) and institutional journal data from countries in focus, this study examines the pervasive domination of men within scholarly journal management in East Swahili and Anglo-West Africa. Results – Findings reveal a widespread dominance of men in the management of scholarly journals in the targeted countries despite the considerable presence of women in academia. Conclusion – The underrepresentation of women in academic leadership positions carries significant consequences, including a lack of diversity in decision-making processes. Such homogeneity can perpetuate existing disparities and impede progress towards gender equality within academia. Furthermore, discussions concerning gender inequality in academia often neglect the experiences of black women.

Intergroup contact, outgroup knowledge and advantaged group collective action: can who you know and what you know promote social change?

Some groups in society unjustly hold greater social, economic, and political power over others, placing some groups in more advantaged and others in more disadvantaged positions. One way to challenge group-based inequality and promote social change is through collective action (e.g., protests, petitions, advocating). Most often, disadvantaged group members engage in collective action. However, when advantaged group members engage in solidarity-based collective action, it can heighten a movement's momentum. Four motivators of collective action among advantaged (and disadvantaged) group members have been identified: identification with the cause, anger about injustice, morality, and group efficacy. We examined what precedes these motivations regarding White Canadians' collective action benefitting Indigenous communities and White Americans' collective action benefitting Black communities. We examined two potential antecedents of advantaged group collective action motivation, intergroup contact and knowledge about the outgroup. In both samples, intergroup contact and knowledge of the outgroup were consistently indirectly associated with collective action through identification with the cause as well as through identification with the cause and anger about injustice. Of the multiple forms of intergroup contact and knowledge examined, the strongest associations were observed for higher quality contact and knowledge of systemic racism. These results have implications for both theory and intervention.

Aging Black Men Living with HIV: How Poor Mental Health, Social Issues, Lifestyle Factors, and Multimorbidity Interrelate

Aging Black Men Living with HIV: How Poor Mental Health, Social Issues, Lifestyle Factors, and Multimorbidity Interrelate

Pre‐reparations Preparation: Fixing the Plumbing before Turning on the Tap

ABSTRACTA growing number of communities in the global African diaspora are campaigning for reparations for historical and contemporary human rights violations. While the political advocacy campaigns continue, communities which are set to receive reparations should, through a process called pre‐reparations preparation, consider their current economic situation and how they may improve their circumstances with the restitution that they will receive. An integral part of pre‐reparations preparation is investigating community income and expenditure. This article explores the use of the leaky bucket analogy in assessing the Black American community's financial inflows and outflows, how Black communities can use this process to plan pre‐ and post‐payment community economic development, and why government administrators and regulators should engage in their own pre‐reparations preparation.

Abstract A019: Black race and CA 19-9 nonproduction is associated with limited pathologic response to neoadjuvant chemotherapy in patients with localized pancreatic cancer

Abstract Introduction: Black patients with pancreatic ductal adenocarcinoma (PDAC) are less likely to have major pathologic response (MPR) following induction chemotherapy. Our previous study suggested a lower baseline CA 19-9 among Black patients. We aimed to determine if CA 19-9 nonproduction contributes to racial differences in neoadjuvant chemotherapy (NAC) response. We then investigated the biological mechanisms underlying reduced response in CAnonprod with multi-omic analysis. Methods: Black and White patients with PDAC receiving ≥ 2 cycles of NAC followed by pancreatectomy at 7 high-volume centers were reviewed. Patients were categorized as CAproducers (CAprod, CA 19-9 &amp;gt; 5 U/mL) or CAnonprod (CA 19-9 ≤ 5 U/mL). Uni- and multi-variable models evaluated differences in rates of CAnonprod by race, and the association of CAnonprod with MPR (CAP 0/1). The Pancreatic Cancer Action Network SPARK platform was queried for patients with CA 19-9 and genomic data. Fisher’s exact test was used to compare differentially mutated genes between CAnonprod and CAprod. Differential gene expression (DEG) analysis identified significantly differentially expressed genes using an absolute fold change of ≥ 2 and p-adj &amp;lt; 0.05 as a cutoff. quanTIseq computational pipeline was used for immune cell deconvolution analysis of the two groups. Results: Our cohort included 385 CAprod and 30 CAnonprod. CAnonprod had a significantly higher rate of Black patients (50% vs 13%, p&amp;lt;0.01). Compared with CAprod, CAnonprod received similar rates of FOLFIRINOX (60% vs. 57%, p=0.27) and duration of NAC (4 vs 5 cycles, p=0.83). Rate of MPR was higher among CAprod compared to CAnonprod (26% vs 8%, p=0.03). No CAnonprod patient had a complete pathologic response vs 28 (7%) of CAprod (p=0.12). CAnonprod was independently associated with decreased odds of MPR (OR 0.21, CI [0.04-0.99]). Black race was independently associated with increased odds of CAnonprod (OR 8.66, CI [3.81 – 19.7]). When CA 19-9 production status was matched by race, there was no difference between rate of MPR between White and Black CAnonprod; both experienced low rates of MPR (12% and 9%, respectively, (p=0.68)). CAnonprod had higher rates of SWI/SNF alterations (50% CAnonprod vs 33% CAprod, p&amp;lt; 0.01; P-adj=ns), and ARID1B was the most frequently mutated gene in CAnonprod (28% vs 11%, p&amp;lt; 0.01; P-adj=ns). DEG analysis showed the LIPF gene was significantly downregulated in CAnonprod compared to CAprod. There was no difference in immune cell distribution between CAprod and CAnonprod. Conclusion: CA 19-9 non-production is more prevalent in Black patients and potentially mediates the lower rates of MPR following NAC. CA 19-9 non-production is associated with higher rates of SWI/SNF alterations and a downregulation of the LIPF gene encoding gastric lipase, unveiling a potential biologic or metabolomic difference in response to chemotherapy between races. Citation Format: Mary P. Martos, Erin M. Dickey, Kawther Abdilleh, Syed A. Ahmad, Shishir K. Maithel, Chet W. Hammill, Hong Jin Kim, Daniel E. Abbott, David A. Kooby, Alexander A. Parikh, Peter J. Hosein, Nipun B. Merchant, Jashodeep Datta, Caitlin A. Hester. Black race and CA 19-9 nonproduction is associated with limited pathologic response to neoadjuvant chemotherapy in patients with localized pancreatic cancer [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Advances in Pancreatic Cancer Research; 2024 Sep 15-18; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2024;84(17 Suppl_2):Abstract nr A019.

A portrait of white progressivism: Chimamanda Ngozi Adichie’s Americanah

ABSTRACT This article explores Chimamanda Ngozi Adichie’s novel Americanah (2013) as a work that intentionally engages “whiteness”. Specifically, it argues that Adichie’s novel trains its attention on white progressives in the USA – those segments of the white American community who are not overtly racist and who might even see themselves as empathetic allies and partners to the Black community. In doing so, it claims that Americanah surveys the range of practices, behaviours, and discourses of white progressives that quite often reproduce harmful (though perhaps unintended) effects like race evasion, racial defensiveness, paternalism and saviorism – habits that are deeply rooted in the way white Americans see themselves and others in society and that are difficult to address and dislodge. The article concludes that the novel is pessimistic about the possibility of any sustained and meaningful understanding and unity of social and political purpose between Black and African people and white progressives.

Intervening on Metabolic Dysfunction-Associated Steatotic Liver Disease in Latino/a and Black Patients with Diabetes: A Feasibility Pilot.

Patients with type 2 diabetes (T2D), particularly those from historically marginalized racial and ethnic groups, are at high risk of poor outcomes from metabolic dysfunction-associated steatotic liver disease (MASLD). Evidence-based management (EBM) of MASLD can prevent its progression to cirrhosis and poor outcomes, yet rates of EBM of MASLD are low in T2D. In this pilot study of ten participants, we examined the feasibility and acceptability of a telehealth intervention that delivered EBM of MASLD in Latino/a and Black patients with T2D in the Duke Healthcare System. The intervention included: (a) MASLD education; (b) diet/lifestyle counseling; (c) T2D medication adjustment (i.e., to promote liver health) and (d) ordering of clinically indicated tests and referrals. This 3-month intervention was delivered by an endocrinologist over three virtual study visits. Phone interviews were conducted at study conclusion. We examined rates of recruitment, retention, T2D medication adjustment, and ordering of clinically indicated tests/referrals. The median age of our cohort was 54.0 (44.0, 59.0); six and four participants self-identified as Latino/a ethnicity and Black race, respectively. Retention rate in this study was 100% (n = 10/10), and all scheduled visits were completed (n = 30/30). Recruitment occurred over one month, and the rate was 25.8% (n = 8/31) by telephone call and 10% (n = 2/20) by electronic health record message. The intervention was highly acceptable based on a median Treatment Acceptability and Preferences score of 4.0 (4.0, 4.0). In exit interviews, all participants reported improved understanding of MASLD and its link to diabetes. All participants received T2D medication adjustment (n = 5/10) and/or clinically indicated testing/referral (n = 10/10) for the purpose of improving MASLD. We demonstrated that a telehealth intervention designed to proactively deliver EBM of MASLD was feasible and acceptable in a cohort of Latino/a and Black patients with T2D. Opportunities existed to better align each participants' care with guideline-based care of MASLD.

The causal effect of skin color bias in online dating

Despite the expansive literature on U.S. ethnoracial relations, issues such as reliance on observational data and inconsistent measures of skin color limit the research on skin color stratification and cross-ethnoracial relationships. These issues hinder researchers’ capacity to disentangle the causal effect of colorism in perpetuating discrepancies within intergroup relationships, specifically within the context of online dating, a popular form of modern dating. In May–June 2021, I fielded a survey experiment that features online dating profiles of Black daters in which skin tone is the treatment. While the multivariate analyses show no statistically significant differences between light- and medium-toned daters, profiles featuring dark-skinned daters consistently receive a penalty in comparison to profiles of light- and medium-skinned people. The results suggest that colorism can have a direct impact on how dark-skinned Black people navigate their romantic lives, independent of other influential factors (e.g., socioeconomic status, social networks, etc.).

In between jockeying and resisting proximities to whiteness: the challenges and promises of cross-racial solidarity

ABSTRACT This paper examines how white supremacy structures relations between colonized groups within contemporary spaces because the structures and allocations of power are inherently constructed as a process of jockeying for power based on proximity and mimicry of whiteness. This results in battles amongst oppressed groups for increased power to secure a space for the self by impressing the white power structure. These battles are waged on the internal front as ingroup dynamics based on shadeism and nationality, and externally between groups such as the evidence of anti-Black racism in South Asian communities and the antipathy towards South Asians in Black communities. Following a historical analysis of the relations between Black and South Asian communities, the authors, examine the nuances, complexities, and impacts of cross-racial violence in schooling within and across Black and South Asian communities in Toronto, Canada. This paper frames communal networks as a possibility for cross-racial solidarities.

Emerging trends and demographic disparities in anal cancer mortality across the United States census regions: An analysis of National Center for Health Statistics mortality data.

Anal cancer, despite its rarity, is a matter of serious concern in the United States, with an uptrend in recent years and marked racial disparities in mortality rates. The aim of this work was to investigate anal cancer mortality trends and sex race disparities in the United States from 1999 to 2020. This is a retrospective study using data from the CDC WONDER database (1999-2020). We investigated deaths attributed to anal cancer, identified by the ICD-10 code C21.1, and excluded individuals aged 14 years and under. The Mann-Kendall trend test was used to investigate temporal trends and a t-test was used to compare continuous variables. Both male and female age-adjusted mortality attributed to anal cancer increased significantly during the study period across all subgroups, including race (Black and White), US Census region (Northeast, Midwest, South and West) and age (15-64 and ≥65 years) (p < 0.001 for all comparisons). For each subgroup, women demonstrated significantly higher rates of mortality than men, except in the Black population, where Black men had higher rates than Black women (0.40 vs. 0.29, p < 0.001). Additionally, Black men had significantly higher mean mortality rates than White men (0.40 vs. 0.27, p < 0.001). The highest rates of anal cancer mortality were among geriatric individuals, especially women aged ≥65 years, at 1.18 per 100 000. The rise in anal cancer mortality and racial and sex disparities present a significant challenge for healthcare providers and policy makers. Further studies are required to devise evidence-based strategies to effectively tackle this challenge.

The Mental Health Consequences of George Floyd's Murder in Minneapolis in Black, Latine, and White Communities.

The high-profile police murder of George Floyd is likely to have an aftermath of negative health consequences, particularly among Black people. Our study evaluates the impact of the murder of Mr. Floyd on mental health in Black, Latine, and white communities in Minneapolis, Minnesota. We constructed a panel dataset merging data from the Minnesota Hospital Association, Minnesota Department of Natural Resources, Minneapolis Police Department, and American Community Survey. First, we specify an overall and racial subgroup autoregressive interrupted time-series design to identify the impact of the murder on rates of mental health hospital discharge at the city-level. We then examine the spatial heterogeneity in the impact of the murder by specifying zip code tabulation area (ZCTA)-level panel models. We find a 0.23 per 1,000 increase in mental health conditions among Black people in the immediate post-murder period, followed by a weekly decline (-.007) in mental health diagnoses. We do not find a substantial rate increase in White or Latine residents. Further, our analyses at the ZCTA-week-level corroborate these findings, while showing that the increase for Black residents was global. These findings speak to the traumatizing effects of police violence and the short- and longer-term public health consequences for Black communities.

Influence of Bust Size and Waist Circumference on Electrocardiographic Left Ventricular Voltage Index in Blacks Africans

Background: Several studies have investigated on relationship between anthropometric characteristics andelectrocardiographic left ventricular mass (LVM). These studies, performed mainly in Caucasians, have mostlyfocused on influence of body mass index on left ventricular voltage indices (LVVI), and rarely on bust size and/or waist circumference.Aim: To determine influence of bust size and waist circumference on LVVI in healthy sedentary people of blackAfrican origin.Method: Experimental, prospective, cross-sectional descriptive study including 66 volunteers (20 women) aged 18to 35 years. They were received in morning on empty stomach. Bust size and waist circumference were measuredwith tape measure. Standard electrocardiogram was performed at rest. R and S wave amplitude and QRScomplex duration were measured. Sokolow-Lyon, R in aVL, Cornell and Cornell product indexes were calculated.Correlation was sought between each LVVI and anthropometric characteristics studied.Results: Bust size and waist circumference were positively correlated with LVVI. Correlation with bust size wasstatistically significant for all LVVI except for R in aVL index, while for waist circumference it was only significantwith R in aVL index.Conclusion: This study confirms relationship between anthropometric characteristics and LVVI. Therefore,interpretation of LVM anomalies from LVVI should also take into consideration morphotype of each individual.

THE CREATIVE PERSONALITY OF SERGEI YESENIN IN PERCEPTION OF THE RUSSIAN PHILOSOPHER ALEKSANDR KONSTANTINOVICH GORSKIY

The article offers the first experience of studying the reception of the creative personality of Sergei Yesenin by one of the prominent representatives of Russian religious cosmism, philosopher, poet, publicist Aleksandr Konstantinovich Gorskiy (1886–1943), whose legacy only recently became publicly available to researchers. The main milestones of Aleksandr Gorskiy’s creative biography, the formation and key aspects of his philosophical teaching are traced; the reasons for Aleksandr Gorskiy’s interest in Yesenin’s poetry are explained, despite the lack of personal contacts between them, the philosopher’s appeals, recorded in his works and letters, to selected pages of the poet’s life are explicated and commented on. It is indicated that in Aleksandr Gorskiy’s philosophical constructions, a significant place is occupied by criticism of the death-worshipping attitude both in literature and in religion. The authors of the article pay special attention to the analysis of Aleksandr Gorskiy’s memorial poem “Yesenin”, where this attitude is clearly manifested. It is shown that in this work the philosopher creates an ambiguous image of the late poet, who not only thoughtlessly squandered his God-given talent, but also subordinated all his power to the idea of self-destruction. The author’s dating of the memorial text – 1925 – is disputed due to the presence in the content of the lyrical epitaph of reminiscences from the poem “The Black Man”, published only in January 1926. It is established that in Gorskiy’s later works, references to Yesenin’s work could potentially indicate a revaluation of the philosopher’s previous judgments about the poet. The materials of this article will be in demand with preparing the section “Yesenin and His Contemporaries” in “Yesenin Encyclopedia”.

Public Health Nurse Partnerships to Advance Environmental Justice and Heart Health in a Black Community

Public Health Nurse Partnerships to Advance Environmental Justice and Heart Health in a Black Community

Clinical rebound after treatment with nirmatrelvir/ritonavir in COVID-19

BackgroundNirmatrelvir/ritonavir (NM/r) is a safe and effective oral antiviral therapeutic used for treatment of mild-to-moderate COVID-19. Case reports described a clinical rebound syndrome whereby individuals experience a relapse of symptoms shortly after completing successful treatment. There is a lack of information on frequency of COVID-19 rebound after NM/r in routine clinical care, contributing factors, and clinical outcomes.MethodsWe reviewed electronic medical records to verify COVID-19 diagnosis, symptoms, and treatment with NM/r from January-June 2022. We defined COVID-19 clinical rebound as clear improvement in symptoms followed by recurrence or worsening of symptoms within 30 days of a five-day course of NM/r.ResultsWe studied 268 adults with median age 57 (IQR 47, 68), 80% White race, 85% non-Hispanic ethnicity, 55% female, 80% vaccinated and boosted against SARS-CoV-2, and 68% with any co-morbidity. Sixteen (6.0%) of studied patients were determined to have COVID-19 clinical rebound. The median time from starting NM/r to rebound was 11 days (IQR 9, 13). Notable demographic and clinical factors with higher proportion (not statistically significant) among COVID-19 rebound patients were female sex (75% rebound vs. 54.5% no rebound), Black race (12.5% rebound vs. 4.9% no rebound), presence of at least one co-morbidity (81.3% rebound vs. 67.5% no rebound), and lack of prior SARS-CoV-2 infection (100% rebound vs. 92.9% no rebound). Only one patient (6.25%) was hospitalized after COVID-19 rebound.ConclusionsCOVID-19 clinical rebound after treatment with NM/r is mild with favorable outcomes and more common than previously reported from real-world clinical care studies.