Introduction: African Americans (AAs) have a higher risk for post-PCI ischemic events and worse COVID-19-related events than non-AAs. Race and gender-related post-PCI events before and during the COVID-19 pandemic in a community hospital setup are unknown. Methods: Demographics and one-year post-PCI ischemic event occurrences were compared between AAs and non-AAs undergoing PCI immediately before (2017-2019) and during COVID-19 (2020-2022) in an urban community hospital. Results: In total, 291 and 292 non-AAs and 221 and 219 AAs who underwent PCI before and during the COVID-19 pandemic respectively, were included in the analysis. AAs were younger and had a higher prevalence of diabetes and ACS (p<0.01 for all). Among non-AAs, there were no differences in major demographics except a higher % of pts with prior PCI (p=0.02) before vs. during COVID-19. Platelet counts were higher in both groups during COVID-19 (p≤0.008) (Table). Among AAs, % of pts with ACS was higher during COVID-19 (p=0.003) which was mainly driven by a higher % of NSTE-ACS (p<0.001). In total, one-year recurrent ischemic events were higher during the COVID-19 pandemic compared to before (112 vs. 198, p<0.001). Among non-AAs, although the total number of events was higher during COVID-19 (p<0.001), % of pts with events were similar and all-cause death and MI were higher during the COVID-19 (p≤0.008). Among AAs, both total events and % of pts with events were higher during COVID-19 (p≥0.02). Except for all-cause death, other ischemic events were higher in AAs during COVID-19 (p≤0.02) which occurred in men (p=0.0001) but not in women (p=ns). TIMI bleeding events were numerically lower during COVID-19 Conclusions: In our community hospital, AAs have a higher risk for post-PCI ischemic events which mainly occurred in men during COVID-19, whereas non-AAs have a similar risk before and during COVID-19. This data suggest that AA men with COVID-19 undergoing PCI should be treated with aggressive antiplatelet therapy.