Bismuth Selenide Nanoparticles Research Articles

Bismuth selenide nanoparticles enhance radiation sensitivity in colon cancer cells in-vitro

BackgroundRadiotherapy is one of the primary treatments for cancer, but it can cause damage to normal tissues and lead to side effects. The use of radiosensitizers can enhance the sensitivity of cancer cells to radiation, thereby reducing the amount of radiation required and minimizing damage to healthy tissues. Bismuth selenide nanoparticles (Bi2Se3 NPs) have been shown to have potential as radiosensitizers. Materials and methodsIn this study, we investigated the potential of Bi2Se3 NPs as a radiosensitizer in colon cancer cells (HCT-116) in vitro. The cells were treated with various concentrations of Bi2Se3 NPs and then exposed to ionizing radiation. The viability of the cells was assessed using the MTT assay, and the survival rate was evaluated. ResultsOur results showed that Bi2Se3 NPs significantly enhanced the sensitivity of colon cancer cells to ionizing radiation in a dose-dependent manner. The combination of Bi2Se3 NPs and radiation resulted in a significant decrease in cell viability and survival rate compared to radiation alone. ConclusionBi2Se3 NPs have the potential to be used as a radiosensitizer in the treatment of colon cancer. The findings of this study suggest that combining Bi2Se3 NPs with radiation may enhance the effectiveness of radiotherapy and reduce the mortality rate associated with colon cancer. Further studies are needed to investigate the safety and efficacy of this approach in vivo.

Construction of MIP/Bi2S3 nanoparticles/rGO nanoprobe for simultaneous electrochemical determination of amoxicillin and clavulanic acid

Herein, a dual-template electrochemical sensor was developed for simultaneous determination of electro-active drug e.g. amoxicillin (AMOX) and electro-inactive drug e.g. clavulanate potassium (CLAV). The sensor consists of bismuth selenide nanoparticles (Bi2Se3 NPs) modified reduced graphene oxide (rGO), over which a thin film of molecular imprinted polymer was formed (MIP/Bi2Se3 NPs@ rGO). AMOX was directly oxidized on the surface of the as-fabricated sensor while CLAV decreased the current peak of a redox probe. The proposed MIP-based electrochemical sensor exhibited wide-linear ranges of 1.42–1100 μM and 0.2–1100 μM for AMOX and CLAV, respectively, with respective limit of detection (S/N = 3) values of 0.43 μM AND 0.06 μM. Additionally, the proposed sensor was efficiently applied for the analysis of pharmaceutical tablets and human serum samples with recoveries % in the range of 98.0–103.1% and RSDs % less than 3.6%. The results of the determination agreed well with HPLC/UV method. The synergism between MIP and Bi2Se3 NPs@ rGO resulted in many advantages including high selectivity, low detection limits, good stability, and high reliability. The proposed sensor exhibited a new venue for simultaneous determination of electro-active and electro-inactive species during therapeutic drug monitoring (TDM).

Synthesis of Bismuth Selenide nanoparticles and its Photocatalytic activity for the degradation of some textile dyes

Synthesis of Bismuth Selenide nanoparticles and its Photocatalytic activity for the degradation of some textile dyes

Cost effective synthesis of CuxBi2-xSe3 photocatalysts by sol-gel method and their enhanced photodegradation and antibacterial activities

A simple sol-gel approach was used to synthesize Cu doped Bismuth Selenide nanoparticles denoted as CuxBi2-xSe3 (x = 0.1, 0.2), in order to comprehend the effect of Cu-dopant on the photocatalytic and antibacterial activity of Bismuth Selenide. The structural properties of prepared samples were investigated by the XRD technique and results showed the formation of hexagonal CuxBi2-xSe3 (x = 0.1, 0.2). The average crystallite size of CuxBi2-xSe3 was found to increase from 39 nm to 42 nm with the increase in the concentration of Cu ions. Atomic force microscopy (AFM) was used to confirm the morphology and particle size of prepared samples. Photoluminescence (PL) studies revealed the decrease in band gap from 1.66 eV to 1.61 eV for Cu0.1Bi1.9Se3 and Cu0.2Bi1.8Se3, respectively. The Raman spectra of CuxBi2-xSe3 (x = 0.1, 0.2) showed two vibrational modes at 130 cm−1 and 170 cm−1. The photocatalytic performance of prepared nanoparticles was evaluated by the removal of methyl blue (MB) and malachite green (MG), under natural sunlight. Cu doped Bismuth Selenide Cu0.2Bi1.8Se3 exhibited higher photocatalytic activity as compared to Cu0.1Bi1.9Se3 and undoped Bismuth Selenide with the 97% and 99% degradation of MB and MG, respectively. Hence, Cu doping proved an efficient way to enhance the photocatalytic response of Bismuth Selenide. Through the antibacterial activity, it was further disclosed that the Cu doped samples had better inhibition zones than undoped Bismuth Selenide. The maximum inhibition zone (29 mm) was observed at optimum doping concentration for Cu0.2Bi1.8Se3. From the results, it can be deduced that Cu0.2Bi1.8Se3 can be as effective photocatalytic and antibacterial agent to treat water pollution.

Sol-gel synthesis of topological insulator bismuth selenide nanoparticles by using different solvents

This paper reports about the Sol-Gel synthesis of Bismuth Selenide (Bi2Se3) nanoparticles by using different solvents (DMF, Ethanol and (DMF+Ethanol)) for their potential in topological insulators. Various characterization techniques: X-ray diffraction (XRD), Fourier Transform Infrared spectroscopy (FTIR), photoluminescence (PL), and scanning electron microscope (SEM) were used to characterize the nano-powder. To get valuable information about dielectric behavior, AC impedance and conductivity were studied. The XRD measurements of Bismuth Selenide proved the crystalline form and orthorhombic crystal structure. The grain size (G) of Bismuth Selenide prepared in different solvents e.g., DMF, Ethanol, DMF+ Ethanol were calculated at 68 nm, 78 nm, and 84 nm respectively. FTIR study showed that the wavenumber corresponding to 660-800cm-1 represents the vibrational bands of Bismuth Selenide (Bi2Se3). Photoluminescence analysis revealed that the maximum absorption was at 801 nm and the bandgap was approximately 1.7eV for all the solvents. The surface morphology of the synthesized Bismuth Selenide (Bi2Se3) was studied with the help of a scanning electron microscope (SEM). The dielectric study showed the frequency effect on dielectric constant (έ), dielectric loss (Ɛ"), tangent loss (tanδ), impedance (Z), and AC conductivity.

Simple synthesis of multifunctional bismuth selenide nanoparticles; structural, optical characterizations and their effective antibacterial activity

Simple synthesis of multifunctional bismuth selenide nanoparticles; structural, optical characterizations and their effective antibacterial activity

Degradation of Congo red dye using ternary metal selenide-chitosan microspheres as robust and reusable catalysts

Water pollution is a threatening environmental concern these days, which requires serious attention. Water is contaminated by the heavy discharge of industrial effluents containing organic wastes. Herein, this research work focused on the demand for overcoming water pollution utilizing clean and renewable energy (solar light irradiations) sources for photocatalytic degradation of Congo red (CR) dye with the help of ternary metal selenide-chitosan microspheres (ZBiSe-CM). First, zinc–bismuth-selenide nanoparticles (ZBiSe-NPs) were successfully synthesized via the solvothermal process and then supported with chitosan to prevent leaching of the catalyst. SEM micrographs showed the average size of newly synthesized nanocomposites catalysts was 30.9 nm. The average size of the ZBiSe-CM microspheres was calculated as 812 um with a spherical shape and a porous surface. The presence of prominent peaks in the EDX spectrum for bismuth, selenium, and zinc confirmed the synthesis of the nanoparticles. XRD analysis demonstrated the calculated crystallite size of ZBiSe-NPs was 27.04 nm. The photocatalytic behavior of the catalyst was studied at optimized experimental conditions. The ZBiSe-NPs showed high photocatalytic degradation efficiency (up to 99.63%) for 40 ppm concentration of CR at catalyst dosage 0.225 g, pH 8.0, and temperature 36–38 °C for 2 h of solar light illumination. Photodegradation of CR dye in the presence of ZBiSe-CM follows pseudo-first-order kinetics and the ZBiSe-CM degraded CR dye in five consecutive cycles with high decontamination efficiency. The newly synthesized ternary metal selenide-chitosan microspheres could be used for the decontamination of dyes from industrial wastewater. • New ternary metal selenide-chitosan microspheres were synthesized. • Structural and morphological characteristics of ZBSe-CM were scrutinized. • Highly efficient photocatalytic degradation of carcinogenic Congo red dye. • Factors influencing the degradation phenomena are investigated.

Synthesis, characterization and applications of Aniline passivated bismuth selenide thermoelectric nanoparticles

Thermoelectric materials have been around since more than a hundred years with applications related to cooling and power generation. The most commonly used thermoelectric materials were typically semiconductors like tellurides and selenides of bismuth, lead, antimony and their alloys. A recent revival of interest in the study of these materials has been propelled by the global needs for alternative sources of energy and by the advances in field of novel material synthesis and characterization. In particular, bismuth selenide (Bi2Se3) has been characterized as efficient n-type thermoelectric materials. Another intriguing property of Bi2Se3 is that it behaves like a topological insulator with a conducting surface and an insulating bulk. This has also led to extensive studies on electronic properties of Bi2Se3.The thermoelectric effect or Seebeck effect is the direct con-version of heat into electric energy when two junctions made up of two dissimilar conductors are held at two different temperatures, T1and T2, with T1 > T2 lead to a voltage being developed between the two junctions. In the present investigation Bismuth selenide nanoparticles are synthesized by two different physical methods namely co-precipitation and hydrothermal method. The resultant nanostructures are characterized by X ray diffraction , SEM , FTIR , UV spectroscopy etc.

NIR light-induced tumor phototherapy using ICG delivery system based on platelet-membrane-camouflaged hollow bismuth selenide nanoparticles

Near-infrared (NIR) light-triggered photothermal therapy (PTT) is a promising treatment strategy for treating cancer. The combination of nanotechnology and NIR has been widely applied. However, the therapeutic efficacy of the drug-delivery system depends on their ability to avoid phagocytosis of endothelial system, cross the biological barriers, prolong circulation life, localize and rapidly release the therapeutic at target sites. In this work, we designed a platelet membrane (PM)-camouflaged hollow mesoporous bismuth selenide nanoparticles (BS NPs) loading with indocyanine green (ICG) (PM@BS-ICG NPs) to achieve the above advantages. PM-coating has active tumor-targeting ability which could prevent drug leakage and provide drug long circulation, causing drug delivery systems to accumulate in tumor sites effectively. Moreover, as a type of the photothermal sensitizers, BS NPs are used as the inner cores to improve ICG stability and are served as scaffolds to enhance the hardness of this drug delivery system. For one hand, the thermal vibration of BS NPs under NIR laser irradiation causes tumor inhibition through hyperthermia. For another hand, this hyperthermia process could damage PM and let ICG rapid release from PM@BS-ICG NPs. The in vitro and in vivo results showed that this biomimetic nano-drug delivery system exhibits obvious antitumor activity which has good application prospect.

CD47-targeted bismuth selenide nanoparticles actualize improved photothermal therapy by increasing macrophage phagocytosis of cancer cells

CD47, a transmembrane protein overexpressed in most tumors, limits macrophage phagocytosis by interacting with macrophage signal-regulated protein α (SIRPα). In this study, we have developed CD47-targeted bismuth selenide nanoparticles (Ab-PEG-Bi2Se3) that increase phagocytosis of cancer cells by macrophages to actualize improved photothermal therapy (PTT). The functionalized nanoparticles were constructed by conjugating anti-CD47 antibody (Ab) to PEGylated bismuth selenide nanoparticles (PEG-Bi2Se3). The anti-CD47 antibody modified on the nanoparticles enhanced the phagocytic activity of macrophages toward tumor cells by specifically blocking the crosstalk between CD47 and SIRPα. Meanwhile, Ab-PEG-Bi2Se3 showed excellent photothermal performance including strong near infrared (NIR) absorbance, high photothermal conversion efficiency and photostability, and exhibited outstanding in vitro PTT effect under NIR laser irradiation. In vivo therapeutic experiments revealed that this CD47-targeted PTT nanoagent, with the assistance of enhanced macrophage phagocytosis, achieved the goal of tumor eradication. Besides, toxicity studies confirmed that Ab-PEG-Bi2Se3 had good biocompatibility. In conclusion, Ab-PEG-Bi2Se3 may serve as an efficient PTT platform in combination with macrophage-mediated immunotherapy to improve antitumor efficacy.

C-C Chemokine Ligand 2 (CCL2) Recruits Macrophage-Membrane-Camouflaged Hollow Bismuth Selenide Nanoparticles To Facilitate Photothermal Sensitivity and Inhibit Lung Metastasis of Breast Cancer.

Poor tumor accumulation, rapid clearance from blood circulation, and high risk of invasive and metastasis are the major barriers that encumber the conventional nanodrug-based tumor therapy. In this work, macrophage membrane (M)-camouflaged quercetin (QE)-loaded hollow bismuth selenide nanoparticles (abbreviated as M@BS-QE NPs) are fabricated for combination therapy of breast cancer. The resulting M@BS-QE NPs are comprehensively characterized, possessing prolonged circulation life, as well as accelerated and enhanced tumoritropic accumulation, compared with those of bare BS NPs because of the immune evading capacity, C-C chemokine ligand 2 (CCL2)-mediated recruitment properties, and active targeting ability. The subsequent QE release under near-infrared (NIR) laser irradiation can selectively sensitize cancer cells to photothermal therapy (PTT) by depleting heat shock protein 70 (HSP70, one malignancy-specific-overexpressed thermoresistance-related chaperone) to realize such a cascaded synergistic effect. At the same time, M@BS-QE NPs down-regulated p-Akt and matrix metalloproteinase-9 (MMP-9, which degrades the extracellular matrix to promote invasion and metastasis of tumors) signal axis to suppress breast cancer lung metastasis. Thus, our results provide a biomimetic strategy, using the characteristics of breast cancer and biological properties of macrophages, that hold great promise to enhance the therapeutic efficacy and improve the accuracy of treatment with minimal side effects on both primary and lung metastasis of breast cancer.

Bifunctional Au@Bi2 Se3 Core-Shell Nanoparticle for Synergetic Therapy by SERS-Traceable AntagomiR Delivery and Photothermal Treatment.

For the first time, topological insulator bismuth selenide nanoparticles (Bi2 Se3 NP) are core-shelled with gold (Au@Bi2 Se3 ) i) to represent considerably small-sized (11 nm) plasmonic nanoparticles, enabling accurate bioimaging in the near-infrared region; ii) to substantially improve Bi2 Se3 biocompatibility, iii) water dispersibility, and iv) surface functionalization capability through straightforward gold-thiol interaction. The Au@Bi2 Se3 is subsequently functionalized for v) effective targeting of SH-SY5Y cancer cells, vi) disrupting the endosome/lysosome membrane, vii) traceable delivery of antagomiR-152 and further synergetic oncomiR knockdown and photothermal therapy (PTT). Unprecedentedly, it is observed that the Au shell thickness has a significant impact on evoking the exotic plasmonic features of Bi2 Se3 . The Au@Bi2 Se3 possesses a high photothermal conversion efficiency (35.5%) and a remarkable surface plasmonic effect (both properties are approximately twofold higher than those of 50 nm Au nanoparticles). In contrast to the siRNA/miRNA delivery methods, the antagomiR delivery is based on strand displacement, in which the antagomiR-152 is displaced by oncomiR-152 followed by a surface-enhanced Raman spectroscopy signal drop. This enables both cancer cell diagnosis and in vitro real-time monitoring of the antagomiR release. This selective PTT nanoparticle can also efficiently target solid tumors and undergo in vivo PTT, indicating its potential clinical applications.

Core–Shell Bi2Se3@mSiO2‐PEG as a Multifunctional Drug‐Delivery Nanoplatform for Synergistic Thermo‐Chemotherapy with Infrared Thermal Imaging of Cancer Cells

AbstractThermo‐chemotherapy combining photothermal therapy (PTT) with chemotherapy has become a potent approach for antitumor treatment. In this study, a multifunctional drug‐delivery nanoplatform based on polyethylene glycol (PEG)‐modified mesoporous silica‐coated bismuth selenide nanoparticles (referred to as Bi2Se3@mSiO2‐PEG NPs) is developed for synergistic PTT and chemotherapy with infrared thermal (IRT) imaging of cancer cells. The product shows no/low cytotoxicity, strong near‐infrared (NIR) optical absorption, high photothermal conversion capacity, and stability. Utilizing the prominent photothermal effect, high‐contrast IRT imaging and efficient photothermal killing effect on cancer cells are achieved upon NIR laser irradiation. Moreover, the successful mesoporous silica coating of the Bi2Se3@mSiO2‐PEG NPs cannot only largely improve the stability but also endow the NPs high drug loading capacity. As a proof‐of‐concept model, doxorubicin (DOX) is successfully loaded into the NPs with rather high loading capacity (≈50.0%) via the nanoprecipitation method. It is found that the DOX‐loaded NPs exhibit a bimodal on‐demand pH‐ and NIR‐responsive drug release property, and can realize effective intracellular drug delivery for chemotherapy. The synergistic thermo‐chemotherapy results in a significantly higher antitumor efficacy than either PTT or chemotherapy alone. The work reveals the great potential of such core–shell NPs as a multifunctional drug‐delivery nanosystem for thermo‐chemotherapy.

Bismuth selenide nanoparticles: simple synthesis, characterization, and its light harvesting applications in the presence of novel precursor

Bismuth selenide, Bi2Se3, nanoparticles were synthesized by a new precursor complex, [bis(salicylate)bismuth(II)]; [Bi2(Hsal)3], via a sonochemical method in an aqueous solution. The average diameter of the Bi2Se3 nanoparticles was 25 nm. The efficiency of the Bi2Se3 nanoparticles as a photocatalyst for the decolorization of rhodamine-B and methylene blue using ultraviolet light irradiation has been evaluated. Furthermore, a preliminary study on the possibility of developing a solar cell having the FTO/TiO2/Bi2Se3/Pt-FTO structure was also investigated to produce an inexpensive solar cell by Bi2Se3 nanoparticles. Products were characterized by X-ray diffraction, scanning electron microscopy, transmission electron microscopy, photoluminescence, and EDX analysis.