Background. Allergic diagnosis is based on accurate clinical history and conducting of skin prick tests (sPt) and specific IgE determination. the past decade recombinant allergen components from pollen of birch are available for allergen-specific IgE antibody testing. the major allergen of birch tree pollen is Bet v 1; Bet v 2 is a well described minor allergen. Methods. 83 patients with birch pollinosis (55 male/28 female, age 4-35 years, mean 15,5) were observed. specific IgE levels were determined by using the ImmunoCap (Phadia, sweden); skin prick tests with standard aeroallergens panel was used. Results. All 83 patients had positive skin tests to birch pollen. the levels of specific IgE to rBet v1 had 87,9% of patients, sIgE to rBet v 2 (profilin) 14,5% of patients, sIgE to rBet v 1 and rBet v 2 13,3% of patients. Conclusion. the prevalence of the patients with presence of IgE - antibodies to profiling Bet v2 among citizens of moscow region, sensitized to birch, accounts 14,5%.