Biphenyl Tetrazole Research Articles

New non-peptide angiotensin II receptor antagonists. 2: structure - activity relationship of a series of annelated 2(1H)-pyridinones

The synthesis and angiotensin II antagonist activity of biphenyl tetrazole substituted fused bicyclic analogues of 2-pyridinone is described. Potent antagonist activity was found in the 2-quinolinone, thieno[2,3-b] pyridine and imidazo[c]pyridine series.