Understanding post-translational modifications of targeted protein is of great significance to manipulate physiological processes of eukaryotes. Chemical biology tools have been utilized to investigate the biological roles of those post-translational... Read More
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Studying Reversible Protein Post-translational Modification through Co-translational Modification.
- Chembiochem : a European journal of chemical biology
on Jan 24, 2023
- Genetic Code Expansion Technology
- Post-translational Modification
- Chemical Biology Tools
- Co-translational Modification
- Genetic Technology
- Perspectives Of Technology
- More +
Development and Recent Advances in Lysine and N-Terminal Bioconjugation for Peptides and Proteins
- Molecules
- VOL. 28
on Jan 21, 2023
- Applications In Chemical Biology
- Native Protein Modification
- Regulation Of Protein Function
- Lysine Residue
- Good Nucleophilicity
- Bioconjugation Methods
- More +
The demand for creation of protein diversity and regulation of protein function through native protein modification and post-translational modification has ignited the development of selective chemical modification methods for peptides and proteins. ... Read More
Template-Assembled Synthetic G-Quartets (TASQs): multiTASQing Molecular Tools for Investigating DNA and RNA G-Quadruplex Biology
- Accounts of Chemical Research
on Jan 20, 2023
- G4 Ligands
- Cambridge Dictionary
- Molecular Tools
- Four-stranded DNA
- Rich Sequences
- Biomimetic Approach
- More +
ConspectusBiomimetics is defined as a "practice of making technological design that copies natural processes", with the idea that "nature has already solved the challenges we are trying to solve" (Cambridge Dictionary). The challenge we decided to ad... Read More
Stability of enzyme immobilized on the nanofluidic channel surface
- Analytical Sciences
on Jan 20, 2023
- Biological Chemistry
- Catalytic Cycles
- Immobilization Process
- Enzyme Activities
- Lifetime Metrics
- Nonuniform Space
- More +
The lifetime of an enzyme is critical to prevent system failure and optimize maintenance schedules in biological and analytical chemistry. The lifetime metrics of an enzyme can be evaluated from enzyme activity in terms of catalytic cycles per enzyme... Read More
Knowledge mapping of mitochondrial calcium uniporter from 2011 to 2022: A bibliometric analysis
- Frontiers in Physiology
- VOL. 14
on Jan 20, 2023
- MCU
- Cocited Author
- Role Of Mitochondrial Calcium Uniporter
- Journal Of Biological Chemistry
- Mitochondrial Calcium Homeostasis
- Permeability Transition
- More +
Background: Calcium uptake research has a long history. However, the mitochondrial calcium uniporter (MCU) protein was first discovered in 2011. As investigations of mitochondrial calcium uniporter represent a new research hotspot, a comprehensive an... Read More
Arylazopyrazole-Based Photoswitchable Inhibitors Selective for Escherichia coli Dihydrofolate Reductase
- ACS Chemical Biology
on Jan 20, 2023
- Human DHFR
- Bulky Moieties
- MTX
- Substitution Of Group
- Chemical Tools
- Control Of Activity
- More +
Selective inhibitors of Escherichia coli dihydrofolate reductase (eDHFR) are crucial chemical biology tools that have widespread clinical applications. We developed a set of eDHFR-selective photoswitchable inhibitors by derivatizing the structure of ... Read More
Fast and Bioorthogonal Release of Isocyanates in Living Cells from Iminosydnones and Cycloalkynes
- Journal of the American Chemical Society
on Jan 19, 2023
- Chemical Biology
- Selective Release Of Drugs
- Biological Media
- Higher Reactivity
- Cycloaddition Reactions
- Physiological Conditions
- More +
Bioorthogonal click-and-release reactions are powerful tools for chemical biology, allowing, for example, the selective release of drugs in biological media, including inside animals. Here, we developed two new families of iminosydnone mesoionic reac... Read More
Targeting ferroptosis in cardio‐metabolic‐diseases: Mechanisms and therapeutic prospects
- Medicinal Research Reviews
on Jan 19, 2023
- Cell Biochemistry
- Impaired Antioxidant Capacity
- Mechanism Of Ferroptosis
- Targeting Ferroptosis
- Mitochondrial Malfunction
- RCD
- More +
Cardio-metabolic-diseases (cardio-metabolic-diseases) are leading causes of death and disability worldwide and impose a tremendous burden on whole society as well as individuals. As a new type of regulated cell death (RCD), ferroptosis is distinct fr... Read More
Cycloguanil and Analogues Potently Target DHFR in Cancer Cells to Elicit Anti-Cancer Activity
- Metabolites
- VOL. 13
on Jan 19, 2023
- DHFR In Cells
- NCI-60 Human Tumor Cell Line
- DHFR
- Human Tumor Cell Line Screening
- DHFR Inhibitor
- Chemical Biology Techniques
- More +
Dihydrofolate reductase (DHFR) is an established anti-cancer drug target whose inhibition disrupts folate metabolism and STAT3-dependent gene expression. Cycloguanil was proposed as a DHFR inhibitor in the 1950s and is the active metabolite of clinic... Read More
Fluorescent Probes for Biological Species and Microenvironments: from Rational Design to Bioimaging Applications
- Accounts of Chemical Research
on Jan 18, 2023
- Physiological Processes
- Biological Microenvironments
- Applications In Biological Imaging
- Imaging In Biological Samples
- Small Bioactive Molecules
- Fluorescent Probes
- More +
ConspectusSome important biological species and microenvironments maintain a complex and delicate dynamic balance in life systems, participating in the regulation of various physiological processes and playing indispensable roles in maintaining the h... Read More
Engineering Metastability into a Virus-like Particle to Enable Triggered Dissociation
- Journal of the American Chemical Society
on Jan 18, 2023
- VLP
- Dimer-dimer Interface
- HBV
- Delivery Platform
- Size Exclusion
- Capsid Protein
- More +
For a virus-like particle (VLP) to serve as a delivery platform, the VLP must be able to release its cargo in response to a trigger. Here, we use a chemical biology approach to destabilize a self-assembling capsid for a subsequent triggered disassemb... Read More
Out With a Bang: Celebrating Global Chemical Biology
- ACS Chemical Biology
on Jan 17, 2023
- Chemical Biology
- Chemical Biology Research
- Research In Switzerland
- Competence In Research
- Geographic Location
- Biology Research
- More +
On November 8-10, 2022, 163 participants from all over the world gathered at the Campus Biotech in Geneva, Switzerland to share in the latest research in chemical biology. The fourth international symposium of the Swiss National Centres of Competence... Read More
Application of Virtual Sample Generation and Screening in Process Parameter Optimization of Botanical Medicinal Materials
- Current Topics in Medicinal Chemistry
- VOL. 23
on Jan 17, 2023
- Virtual Sample
- Problem Of Small Sample Size
- Virtual Sample Generation
- Response Surface Function
- Virtual Sample Generation Method
- FFD
- More +
Background: The small sample problem widely exists in the fields of the chemical industry, chemistry, biology, medicine, and food industry. It has been a problem in process modeling and system optimization. The aim of this study is to focus on the p... Read More
Profiling Sulfur(VI) Fluorides as Reactive Functionalities for Chemical Biology Tools and Expansion of the Ligandable Proteome
- ACS Chemical Biology
on Jan 17, 2023
- Sulfur Fluorides
- Serine Sidechains
- CAII
- Lysine Sidechains
- Chemical Applications
- Chemical Expansion
- More +
Here, we report a comprehensive profiling of sulfur(VI) fluorides (SVI-Fs) as reactive groups for chemical biology applications. SVI-Fs are reactive functionalities that modify lysine, tyrosine, histidine, and serine sidechains. A panel of SVI-Fs wer... Read More
Genetic Encoding of a Photocaged Histidine for Light‐Control of Protein Activity
- ChemBioChem
on Jan 15, 2023
- Chemical Biology
- Tool In Chemical Biology
- Chloramphenicol Transferase
- Unnatural Amino Acid
- Genetic Encoding
- Renilla Luciferase
- More +
The use of light to control protein function is a critical tool in chemical biology. Here we describe the addition of a photocaged histidine to the genetic code. This unnatural amino acid becomes histidine upon exposure to light and allows for the op... Read More
Properties of Gaseous Deprotonated L-Cysteine S-Sulfate Anion [cysS-SO3]−: Intramolecular H-Bond Network, Electron Affinity, Chemically Active Site, and Vibrational Fingerprints
- International Journal of Molecular Sciences
- VOL. 24
on Jan 14, 2023
- Biological Chemistry
- Negative Ion Photoelectron Spectroscopy
- Intrinsic Molecular Properties
- NH2 Groups
- HB Acceptor
- Intramolecular Hydrogen Bonds
- More +
L-cysteine S-sulfate, Cys-SSO3H, and their derivatives play essential roles in biological chemistry and pharmaceutical synthesis, yet their intrinsic molecular properties have not been studied to date. In this contribution, the deprotonated anion [cy... Read More
Critical traits of graduate student mentors affecting students’ science identity development in an NSF-funded research experiences for undergraduates (REU) program
- Mentoring & Tutoring: Partnership in Learning
- VOL. ahead-of-print
on Jan 13, 2023
- Science Identity Development
- REU
- Science Identity
- Graduate Student Mentors
- NSF
- Undergraduates Program
- More +
ABSTRACT Reported herein are the findings from a grounded study probing the impact of graduate student mentors in a National Science Foundation (NSF)-funded research experiences for undergraduates (REU) program (2014–2016) in chemistry & chemical bio... Read More
Novel Benzimidazole Derived Imine Ligand and Its Co(III) and Cu(II) Complexes as Anticancer Agents: Chemical Synthesis, DFT Studies, In Vitro and In Vivo Biological Investigations
- Pharmaceuticals
- VOL. 16
on Jan 13, 2023
- Molecular Dynamics Simulations
- Cobalt Metal Ions
- NIH3T3 Cell Lines
- DFT Studies
- DFT
- C1 C4
- More +
The emerging interest in the field of coordination chemistry and their biological applications has created a novel impact in the field of chemical biology. With this motivation, in this work we have synthesized a novel benzimidazole derived imine lig... Read More
Interconnected Set of Enzymes Provide Lysine Biosynthetic Intermediates and Ornithine Derivatives as Key Precursors for the Biosynthesis of Bioactive Secondary Metabolites
- Antibiotics
- VOL. 12
on Jan 12, 2023
- Biosynthesis Of Metabolites
- Non-ribosomal Peptide
- Ornithine Pathways
- Ornithine Derivatives
- Fungal Siderophores
- Supply Of Precursors
- More +
Bacteria, filamentous fungi, and plants synthesize thousands of secondary metabolites with important biological and pharmacological activities. The biosynthesis of these metabolites is performed by networks of complex enzymes such as non-ribosomal pe... Read More
Reactivity and mechanism in chemical and synthetic biology
- Philosophical Transactions of the Royal Society B: Biological Sciences
- VOL. 378
on Jan 11, 2023
- Chemical Biology
- Synthetic Biology
- Physical Organic Chemistry
- Mechanism In Biology
- Mechanistic Thinking
- Alternate Chemistries
- More +
Physical organic chemistry and mechanistic thinking provide a strong intellectual framework for understanding the chemical logic of evolvable informational macromolecules and metabolic transformations in living organisms. These concepts have also led... Read More