Protein ubiquitination regulates almost all eukaryotic cellular processes, and is of very high complexity due to the diversity of ubiquitin (Ub) modifications including mono-, multiply mono-, homotypic poly-, and even heterotypic poly-ubiquitination.... Read More
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Recent progress in dissecting ubiquitin signals with chemical biology tools
- Current Opinion in Chemical Biology
- VOL. 70
on Oct 1, 2022
Chemical biology tools for imaging-based analysis of organelle membranes and lipids
- Current Opinion in Chemical Biology
- VOL. 70
on Oct 1, 2022
Membrane biology studies have revealed that in addition to providing structural support for compartment formation and membrane protein function, subcellular biomembranes are also critically involved in many biological events. To facilitate our unders... Read More
Towards development of disease-modifying therapy for Alzheimer's disease using redox chemical biology pathways
- Current Opinion in Pharmacology
- VOL. 66
on Oct 1, 2022
Redox modifications are described that can be harnessed for the treatment of neurodegenerative disorders, including Alzheimer's disease (AD). The approach has shown potential therapeutic efficacy in AD in both transgenic mouse and hiPSC cerebral orga... Read More
ChemBioPort: an online portal to navigate the structure, function and chemical inhibition of the human proteome.
- Database : the journal of biological databases and curation
- VOL. 2022
on Sep 27, 2022
Chemical probes are important tools to investigate the function of proteins, evaluate their potential as therapeutic targets and provide chemical starting points for drug discovery. As a result, a growing federation of scientists aims to generate che... Read More
Switchable aqueous catalytic systems for organic transformations
- Communications Chemistry
- VOL. 5
on Sep 26, 2022
AbstractIn living organisms, enzyme catalysis takes place in aqueous media with extraordinary spatiotemporal control and precision. The mechanistic knowledge of enzyme catalysis and related approaches of creating a suitable microenvironment for effic... Read More
Assessment of the biological effect of metal ions and their complexes using Allium cepa and Artemia salina assays: a possible environmental implementation of biological inorganic chemistry
- JBIC Journal of Biological Inorganic Chemistry
on Sep 23, 2022
AbstractThe pollution of aquatic ecosystems due to the elevated concentration of a variety of contaminants, such as metal ions, poses a threat to humankind, as these ecosystems are in high relevance with human activities and survivability. The exposu... Read More
A Toolkit for Engineering Proteins in Living Cells: Peptide with a Tryptophan-Selective Ru-TAP Complex to Regioselectively Photolabel Specific Proteins
- Journal of the American Chemical Society
on Sep 22, 2022
Using a chemical approach to crosslink functionally versatile bioeffectors (such as peptides) to native proteins of interest (POI) directly inside a living cell is a useful toolbox for chemical biologists. However, this goal has not been reached due ... Read More
Main group cyanides: from hydrogen cyanide to cyanido-complexes
- Reviews in Inorganic Chemistry
- VOL. 0
on Sep 21, 2022
Abstract Homoleptic cyanide compounds exist of almost all main group elements. While the alkali metals and alkaline earth metals form cyanide salts, the cyanides of the lighter main group elements occur mainly as covalent compounds. Th... Read More
Strategies in synthetic design and structure–activity relationship studies of novel heterocyclic scaffolds as aldose reductase‐2 inhibitors
- Archiv der Pharmazie
on Sep 20, 2022
Heterocyclic scaffolds of natural as well as synthetic origin provide almost all categories of drugs exhibiting a wide range of pharmacological activities, such as antibiotics, antidiabetic and anticancer agents, and so on. Under normal homeostasis, ... Read More
Metal/Non‐Metal Catalyzed Activation of Organic Nitriles
- The Chemical Record
on Sep 20, 2022
Nitrile activation is a prominent topic in recent developments in chemistry, especially in organic, inorganic, biological chemistry, as well as in the natural synthesis of products and in the pharmaceutical industry. The activation of nitriles using ... Read More
Purine–Purine Base Pairs in Parallel DNA: β-D Anomeric 8-Aza-7-deazaisoguanine and 7-Functionalized Conjugates Form Stable Base Pairs with α-D 5-Aza-7-deaza-2′-deoxyguanosine
- Bioconjugate Chemistry
on Sep 20, 2022
Anomeric purine-purine DNA represents a new recognition system with strands in parallel orientation. This work investigates the new heterochiral system and the positional impact of nucleobase functionalization. Tracts of anomeric isoguanine/8-aza-7-d... Read More
Neratinib as a Potential Therapeutic for Mutant RAS and Osimertinib-Resistant Tumours
- European Medical Journal
on Sep 20, 2022
Neratinib was developed as an irreversible catalytic inhibitor of ERBB2, which also acts to inhibit ERBB1 and ERBB4. Neratinib is U.S. Food and Drug Administration (FDA)-approved as a neo-adjuvant therapy for use in HER2+ breast cancer. More recently... Read More
Development of a New DHFR-Based Destabilizing Domain with Enhanced Basal Turnover and Applicability in Mammalian Systems
- ACS Chemical Biology
on Sep 19, 2022
Destabilizing domains (DDs) are an attractive strategy allowing for positive post-transcriptional small molecule-regulatable control of a fusion protein's abundance. However, in many instances, the currently available DDs suffer from higher-than-desi... Read More
A Novel Family of Acid-Cleavable Linker Based on Cyclic Acetal Motifs for the Production of Antibody-Drug Conjugates with High Potency and Selectivity
- Bioconjugate Chemistry
on Sep 15, 2022
Cleavable linkers have become the subject of intense study in the field of chemical biology, particularly because of their applications in the construction of antibody-drug conjugates (ADC), where they facilitate lysosomal cleavage and liberation of ... Read More
Synthesis of biotinylated-LPG as a chemical biology tool enabling discovery of ALCAT1 modulators.
- Bioorganic & medicinal chemistry letters
- VOL. 72
on Sep 15, 2022
As a mitochondrial signature phospholipid, cardiolipin (CL) is required for membrane structure, respiration, dynamics, fragmentation, and mitophagy. Alteration of CL by reactive oxygen species (ROS) can cause mitochondrial dysfunction, which is impli... Read More
Selective Acylation of Proteins at Gly and Lys in His Tags
- ChemBioChem
on Sep 14, 2022
The chemical modification of proteins is of great importance in chemical biology, biotechnology, and for the production of modified biopharmaceuticals, as it enables introduction of fluorophores, biotin, half-life extending moieties, and more. We hav... Read More
Intramolecular Thiol‐ and Selenol‐Assisted Delivery of Hydrogen Sulfide
- Angewandte Chemie International Edition
on Sep 14, 2022
Arylthioamides have been frequently employed to assess the chemical biology and pharmacology of hydrogen sulfide (H2S). From this class of donors, however, extremely low H2S releasing efficiencies have been reported and proper mechanistic studies hav... Read More
Redox-Controlled Chemical Protein Synthesis: Sundry Shades of Latency
- Accounts of Chemical Research
- VOL. 55
on Sep 9, 2022
ConspectusThe last two decades have witnessed the rise in power of chemical protein synthesis to the point where it now constitutes an established corpus of synthetic methods efficiently complementing biological approaches. One factor explaining this... Read More
Redox-Controlled Chemical Protein Synthesis: Sundry Shades of Latency.
- Accounts of chemical research
on Sep 9, 2022
ConspectusThe last two decades have witnessed the rise in power of chemical protein synthesis to the point where it now constitutes an established corpus of synthetic methods efficiently complementing biological approaches. One factor explaining this... Read More
Biochemistry and Nanomechanical Properties of Human Colon Cells upon Simvastatin, Lovastatin, and Mevastatin Supplementations: Raman Imaging and AFM Studies.
- The journal of physical chemistry. B
on Sep 9, 2022
One of the most important areas of medical science is oncology, which is responsible for both the diagnostics and treatment of cancer diseases. Over the years, there has been an intensive development of cancer diagnostics and treatment. This paper sh... Read More