Super-conserved receptors expressed in the brain: biology and medicinal chemistry efforts. Abstract The super-conserved receptors expressed in the brain (SREB) constitute a family of orphan G protein-coupled receptors that include GPR27 (SREB1), GPR8... Read More
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Super-conserved receptors expressed in the brain: biology and medicinal chemistry efforts.
- Future medicinal chemistry
on May 10, 2022
Commonly Used Alkylating Agents Limit Persulfide Detection by Converting Protein Persulfides into Thioethers.
- Angewandte Chemie (International ed. in English)
on May 4, 2022
Commonly Used Alkylating Agents Limit Persulfide Detection by Converting Protein Persulfides into Thioethers. Abstract Protein persulfides (R-S-SH) have emerged as a common post-translational modification. Detection and quantitation of protein persul... Read More
Cofactor Dynamics Couples the Protein Surface to the Heme in Cytochrome c, Facilitating Electron Transfer.
- The journal of physical chemistry. B
on May 4, 2022
Cofactor Dynamics Couples the Protein Surface to the Heme in Cytochrome c, Facilitating Electron Transfer. Abstract Electron transport through biomolecules and in biological transport networks is of great importance to bioenergetics and biocatalysis.... Read More
The Impact of Activity-based Protein Profiling in Malaria Drug Discovery.
- ChemMedChem
on May 4, 2022
The Impact of Activity-based Protein Profiling in Malaria Drug Discovery. Abstract Activity-based protein profiling (ABPP) is an approach used at the interface of chemical biology and proteomics that uses small molecular probes to provide dynamic fin... Read More
Semi-syntheses and interrogation of indole-substituted Aspidosperma terpenoid alkaloids.
- Organic & biomolecular chemistry
on May 3, 2022
Semi-syntheses and interrogation of indole-substituted Aspidosperma terpenoid alkaloids. Abstract We demonstrated here a series of Aspidosperma terpenoid alkaloids can be quickly prepared using semisynthesis from naturally sourced tabersonine, featur... Read More
Phytomedicines explored under in vitro and in silico studies against coronavirus: An opportunity to develop traditional medicines.
- South African journal of botany : official journal of the South African Association of Botanists = Suid-Afrikaanse tydskrif vir plantkunde : amptelike tydskrif van die Suid-Afrikaanse Genootskap van Plantkundiges
on May 2, 2022
Phytomedicines explored under in vitro and in silico studies against coronavirus: An opportunity to develop traditional medicines. Abstract The widespread COVID-19 pandemic, caused by novel coronavirus SARS-CoV-2, has emanated as one of the most life... Read More
Magnolol and honokiol target TRPC4 to regulate extracellular calcium influx and relax intestinal smooth muscle
- Journal of ethnopharmacology
- VOL. 290
on May 1, 2022
Magnolol and honokiol target TRPC4 to regulate extracellular calcium influx and relax intestinal smooth muscle Abstract Magnolia officinalis Cortex (M. officinalis) is a classical traditional Chinese medicine (TCM) widely used to treat digestive syst... Read More
Dynamic imaging of cell wall polysaccharides by metabolic click-mediated labeling of pectins in living elongating cells.
- The Plant journal : for cell and molecular biology
- VOL. 110
on May 1, 2022
Dynamic imaging of cell wall polysaccharides by metabolic click-mediated labeling of pectins in living elongating cells. Abstract Protein tracking in living plant cells has become routine with the emergence of reporter genes encoding fluorescent tags... Read More
Teaching an old compound new tricks: reversible transamidation in maleamic acids.
- Chemistry (Weinheim an der Bergstrasse, Germany)
on Apr 30, 2022
Teaching an old compound new tricks: reversible transamidation in maleamic acids. Abstract Dynamic combinatorial chemistry is a method widely used for generating responsive libraries of compounds, with applications ranging from chemical biology to ma... Read More
In-vivo production of diverse β-amino acid-containing proteins.
- Angewandte Chemie (International ed. in English)
on Apr 28, 2022
In-vivo production of diverse β-amino acid-containing proteins. Abstract The wide range of moieties installed in ribosomally synthesized and post-translationally modified peptides (RiPPs) suggests largely untapped potential for protein engineering. H... Read More
Chemical Modification for the "off-/on" Regulation of Enzyme Activity.
- Macromolecular rapid communications
on Apr 28, 2022
Chemical Modification for the " off - / on " Regulation of Enzyme Activity. Abstract Enzymes with excellent catalytic performance play important roles in living organisms. Advances in strategies for enzyme chemical modification have enabled powerful ... Read More
Cross-talks between Sulfane Sulfur and Thiol at a Zinc(II) Site.
- Chemistry (Weinheim an der Bergstrasse, Germany)
on Apr 26, 2022
Cross-talks between Sulfane Sulfur and Thiol at a Zinc (II) Site. Abstract Transformations of sulfane sulfur compounds (e.g. organic polysulfides (R - S n - R, n > 2) and elemental sulfur (S 8)) play pivotal roles in the biochemical landscape of sulf... Read More
Mechanistic insights and docking studies of phytomolecules as potential candidates in the management of cancer.
- Current pharmaceutical design
on Apr 26, 2022
Mechanistic insights and docking studies of phytomolecules as potential candidates in the management of cancer. Abstract Cancer is a leading menace of death at the global level, cancer is presently the second most important disease-causing death in b... Read More
Small-molecule discovery in the pancreatic beta cell.
- Current opinion in chemical biology
- VOL. 68
on Apr 26, 2022
Small-molecule discovery in the pancreatic beta cell. Abstract The pancreatic beta cell is the only cell type in the body responsible for insulin secretion, and thus plays a unique role in the control of glucose homeostasis. The loss of beta-cell mas... Read More
Responses of two marine fish to organically complexed Zn: Insights from microbial community and liver transcriptomics.
- The Science of the total environment
- VOL. 835
on Apr 22, 2022
Responses of two marine fish to organically complexed Zn: Insights from microbial community and liver transcriptomics. Abstract The diversity and adjustability of metal-organic complex enhance the function of metals and promote the burgeoning fields ... Read More
Filamentous Thermosensitive Mutant Z: An Appealing Target for Emerging Pathogens and a Trek on Its Natural Inhibitors
- Biology
- VOL. 11
on Apr 20, 2022
Filamentous Thermosensitive Mutant Z: An Appealing Target for Emerging Pathogens and a Trek on Its Natural Inhibitors Abstract Antibiotic resistance is a major emerging issue in the health care sector, as highlighted by the WHO. Filamentous Thermosen... Read More
γ‐Resorcyclic Acid‐Based AIEgens for Illuminating Endoplasmic Reticulum**
- Chemistry – A European Journal
on Apr 20, 2022
γ‐Resorcyclic Acid‐Based AIEgens for Illuminating Endoplasmic Reticulum ** Abstract Endoplasmic reticulum (ER) has emerged as one of the interesting sub-cellular organelles due to its role in myriads of biological phenomena. Subsequently, visualizati... Read More
Isotope Labels Combined with Solution NMR Spectroscopy Make Visible the Invisible Conformations of Small-to-Large RNAs.
- Chemical reviews
on Apr 20, 2022
Isotope Labels Combined with Solution NMR Spectroscopy Make Visible the Invisible Conformations of Small-to-Large RNAs. Abstract RNA is central to the proper function of cellular processes important for life on earth and implicated in various medical... Read More
Resolving the Multidecade-Long Mystery in MoaA Radical SAM Enzyme Reveals New Opportunities to Tackle Human Health Problems.
- ACS bio & med chem Au
- VOL. 2
on Apr 20, 2022
Resolving the Multidecade-Long Mystery in MoaA Radical SAM Enzyme Reveals New Opportunities to Tackle Human Health Problems. Abstract MoaA is one of the most conserved radical S-adenosyl-l-methionine (SAM) enzymes, and is found in most organisms in a... Read More
P2X Receptor Antagonists and their Potential as Therapeutics: a patent review (2010 - 2021).
- Expert opinion on therapeutic patents
on Apr 20, 2022
P2X Receptor Antagonists and their Potential as Therapeutics: a patent review (2010 - 2021). Abstract: Purinergic receptors play a critical role in neurotransmission, and modulation of complex physiological functions. As such, they have been implicat... Read More