Background: The mechanics of heat and mass transfer via nanofluid flow across many media are currently being discussed. “Nanofluids” are fluids that include highly heat-conductive nanoparticles, and they are essential for resolving engineering problems. Under the effects of activation energy, thermal radiation, and motile microorganisms, the process of heat and mass transfer through steady nanofluid flow crosses over stretched surfaces in this scenario.Methodology: For mathematical evaluation, the system of partial differential equations (PDEs) is used to describe this physical framework. By introducing suitable similarity variables with a set of boundary conditions, this mathematical system of PDEs has become a system of ordinary differential equations (ODEs). To obtain numerical results, the MATLAB built-in program “bvp4c” is used to solve the system of first-order equations.Results: In the findings and discussion section, the resulting outcomes are thoroughly examined and visually shown. The flow rate in these systems increases due to the erratic movement of microorganisms. The graphical representation shows the impacts of involving physical factors on the microorganism, thermal, concentration, and momentum profiles. Variations/changes in these profiles can be observed by adjusting the parametric values, as depicted in the graphs. Consequently, thermal transport is boosted by 25%. Additionally, the skin friction, Nusselt, Sherwood, and microbe density numbers are determined numerically. The findings demonstrate that increasing the magnetic field parameter causes the velocity profile to decrease, increasing the radiation parameter leads to an increase in temperature description, and increasing the Lewis number causes the microorganism profile’s transport rate to decrease.