This research was conducted at Binjai Kota Community Health Center. The purpose of this study is to see how employee performance encourages the company to achieve its targets, and to see what influences the level of employee performance. Data collection methods were carried out through a questionnaire using a Likert scale. The sample taken was 68 people. Data were processed using SmartPLS 3.0, analyzed with multiple regressions. The results of this study state that Leadership Style has a positive and significant effect on Job Satisfaction at Binjai Kota Community Health Center with significance of 0,000 (<0,5) with a T-statistic of 3,560 (>1,96). The Original Sample Value is positive, namely 0,329. Work Motivation has a positive and significant effect on Job Satisfaction at Binjai Kota Community Health Center with significance of 0,000 (<0,5) with a T-statistic of 4,336 (>1,96). The Original Sample Value is positive, namely 0,369. Organizational Culture has a positive and significant effect on Job Satisfaction at Binjai Kota Community Health Center with significance of 0,002 (<0,5) with a T-statistic of 3,125 (>1,96). The Original Sample Value is positive, namely 0,326. Leadership Style has a positive and significant effect on Performance at Binjai Kota Community Health Center with significance of 0,018 (<0,5) with a T-statistic of 2,383 (>1,96). The Original Sample Value is positive, namely 0,232. Work Motivation has a positive and significant effect on Performance at Binjai Kota Community Health Center with significance of 0,035 (<0,5) with a T-statistic of 2,112 (>1,96). The Original Sample Value is positive, namely 0,212. Organizational Culture has a positive and significant effect on Performance at Binjai Kota Community Health Center with significance of 0,024 (<0,5) with a T-statistic of 2,261 (>1,96). The Original Sample Value is positive, namely 0,216. Job Satisfaction has a positive and significant effect on Performance at Binjai Kota Community Health Center with significance of 0,002 (<0,5) with a T-statistic of 3,078 (>1,96). The Original Sample Value is positive, namely 0,355. Job Satisfaction can mediate the influence of Leadership Style on Performance at Binjai Kota Community Health Center with significance of 0,013 (<0,5) with a T-statistic of 2,489 (>1,96). The Original Sample Value is positive, namely 0,117. Job Satisfaction can mediate the influence of Work Motivation on Performance at Binjai Kota Community Health Center with significance of 0,015 (<0,5) with a T-statistic of 2,439 (>1,96). The Original Sample Value is positive, namely 0,131. Job Satisfaction can mediate the influence of Organizational Culture on Performance at Binjai Kota Community Health Center with significance of 0,037 (<0,5) with a T-statistic of 2,088 (>1,96). The Original Sample Value is positive, namely 0,116. It is known that the R Square value for each construct is Job Satisfaction at 0,772 with an Adjusted R Square of 0,761, which means 76,1%. Thus, Leadership Style, Work Motivation, and Organizational Culture contribute to explaining Job Satisfaction. Based on the results for Performance, there is an R Square of 0,802 with an Adjusted R Square of 0,789, which means 78,9%. Thus, Leadership Style, Work Motivation, and Organizational Culture contribute to explaining Performance.