Bilateral Type Research Articles

Appendiceal collision tumor presented as acute appendicitis: A dissonant scenario

Renal cell carcinoma arises from the epithelium of the renal tubules and accounts for approximately 3% of adult malignancies. Tumours occur most often in older individuals usually in sixth and seventh decades of life. Bilateral multifocal papillary type of RCC is rare and its presence should prompt the suspicion of some underlying hereditary genetic predisposition thus thorough cytogenetic evaluation and detailed family history could help in finding the etiology. Bilateral RCC could be synchronous or metachronous. We hereby present the autopsy findings of a case of sudden death of a 65 years old male. On histopathological evaluation, both kidneys showed papillary variant of renal cell carcinoma as an incidental finding.

Bilateral multifocal papillary renal cell carcinoma on autopsy: A case report

Renal cell carcinoma arises from the epithelium of the renal tubules and accounts for approximately 3% of adult malignancies. Tumours occur most often in older individuals usually in sixth and seventh decades of life. Bilateral multifocal papillary type of RCC is rare and its presence should prompt the suspicion of some underlying hereditary genetic predisposition thus thorough cytogenetic evaluation and detailed family history could help in finding the etiology. Bilateral RCC could be synchronous or metachronous. We hereby present the autopsy findings of a case of sudden death of a 65 years old male. On histopathological evaluation, both kidneys showed papillary variant of renal cell carcinoma as an incidental finding.

Anatomical differences of intracranial arteries according to sex: a systematic review and meta-analysis

Background and PurposeIntracranial aneurysms are more common in women than in men. Some anatomical variants of the circle of Willis (CoW) are associated with a higher risk of developing intracranial aneurysms. We hypothesized that variations of the CoW are sex dependent which may partly explain why intracranial aneurysms are more common in women. We systematically reviewed and meta-analyzed the literature to compare the presence of anatomical variations of the CoW between women and men in the general population. Material and MethodsA systematic search in Pubmed and EMBASE using predefined criteria, following the PRISMA guidelines was performed. The presence of different CoW anatomical variants and a complete CoW was compared between women and men using an inverse variance weighted random effects meta-analysis to calculate relative risks (RR) with 95% confidence intervals (95% CIs). ResultsFourteen studies were included reporting on 5478 healthy participants (2511 women, 2967 men). Bilateral fetal type posterior cerebral arteries (RR 2.79; 95%CI 1.65–4.72, I2=0%), and a complete CoW (RR 1.24, 95%CI 1.13–1.36; I2=0%) were more prevalent in women than in men. The variants absence or hypoplasia of one of the anterior cerebral arteries (RR 0.58, 95%CI 0.38–0.88, I2=57%) and hypoplasia or absence of both posterior communicating arteries (RR 0.79, 95%CI 0.71–0.87, I2=0%) were more prevalent in men. ConclusionsSeveral anatomical variations of the CoW are sex dependent, with some variants being more common in women while others in men. Future research should assess how these sex-specific CoW variants relate to the sex-specific occurrence of intracranial aneurysms.

Which industrial path contributed to CO2 transfer and emissions slowing-down of China and the United States most in international trade?

Carbon transfer in international trade has triggered disputes on environmental equity between developed and developing countries. Hence, it is urgent to make it clear the carbon transfer process of international trade between China and the United States, explore the adjustment plan of emission reduction responsibility and formulate targeted emission reduction measures. These will play an important leading and demonstration effect in addressing global warming and coordinating international carbon reduction. This study built a CO2 international trade transfer network model of China and the United States. Based on identifying the carbon transfer path flowing from primary product sector to final production sector, and then to final consumption, we analyzed the industrial association relationship and distribution differences between China and the United States with external countries and regions. Lastly, we put forward emission reduction policy implication in industrial scale. The key paths of China and the United States are concentrated in the two export and import transfer types respectively. Among the key paths of China's bilateral primary production export type, paths from domestic Electricity, Gas and Water to foreign Construction accounted for the largest 40% share. As for the United States, transfer type of bilateral final production import is the most prominent, and path number and flow from foreign Transport to domestic Public Administration both accounted for more than 30%. Based on shared responsibility to adjust the emission reduction tasks under the Paris Agreement, China and the US will allow to emit 10% more and reduce 6% more, reaching 54% and 25% respectively. Taking into full consideration the national economic development level and the differences in the production technology level of industrial sectors, as well as the upstream and downstream related sectors' relationship, the refined emission reduction strategy is proposed from different aspects, such as technical assistance, financial support, import control, technology sharing and consumption transformation.

Recanalized paramedian thalamoperforators after intraarterial tirofiban treatment in a patient with bilateral fetal-type PCAs (P8-5.028)

<h3>Objective:</h3> NA <h3>Background:</h3> There are increasing evidence that support the treatment effect of intraarterial tirofiban during endovascular thrombectomy in acute ischemic stroke. Here, we report a patient with bilateral fetal-type PCAs, whose paramedian perforating thalamic-mesencephalic arteries were recanalized after intraarterial tirofiban treatment during thrombectomy. <h3>Design/Methods:</h3> NA <h3>Results:</h3> A 78-year-old woman presented to the emergency room with acute onset of drowsy mentality, gaze palsy and quadriplegia (NIHSS 9). She had a history of hypertension and diabetes. Brain CT scan revealed no definite early ischemic damage and CTA showed steno-occlusion at the left distal VA and bilateral fetal type PCAs. Brain perfusion CT showed perfusion delay in posterior circulation territory. Under local anesthesia, an 6F Envoy^® catheter (Codman) was placed in the left distal VA of distal V2 segment. The angiography revealed the distal VA occlusion (V4 segment) (Fig. 1A). Suction thrombectomy was performed twice using 5F Sofia^® catheter (Microvention), and no clot was extracted (Fig. 1B). Recanalization of left distal VA with underlying severe ICAS at the occlusion site (Fig. 1C). Delayed angiogram showed subtle re-occlusion tendency of left distal VA, 0.5mg of intraarterial tirofiban was injected. Successful recanalization (mTICI 2C) with further recanalized paramedian perforating thalamic-mesencephalic arteries on distal BA after SCA branches was achieved (Fig. 1D). Follow-up brain MRI showed acute infarction at the posterior circulation territory including bilateral thalami. MRA showed patent left distal VA with underlying severe ICAS, and vessel wall MRI showed eccentric wall thickening without contrast enhancement or plaque hemorrhage. The patient recovered well at 1 week (NIHSS 0). <h3>Conclusions:</h3> In a patient with bilateral fetal type PCAs, distal BA could end after SCA branches and this site should be evaluated cautiously, because thalamoperforators could originate. Intraarterial tirofiban could be helpful to recanalize perforating arteries during thrombectomy. <b>Disclosure:</b> Dr. Baik has nothing to disclose.

Sudden Sensorineural Hearing Loss in a Patient with COVID-19: A Case Report

Background: Several viral infections may lead to hearing loss. It›s still unknown whether COVID-19 has effects on the auditory system or not. In this regard, to evaluate the possibility of sudden sensorineural hearing loss due to COVID-19, this study aimed to report sudden sensorineural hearing loss (SSNHL) in patients with COVID-19 in Iran. Case Report: The patient was a 7-year-old girl diagnosed with COVID-19 and sensorineural hearing loss. An audiogram revealed normal hearing in the right ear and severe sensorineural hearing loss in the left ear. The tympanometry test result was bilateral type A. The treatment started with prednisolone (1 mg/kg/d). The audiogram of follow-up pure-tone audiometry did not reveal any improvement. Conclusion: SSNHL appears to be a possible complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. COVID-19 infection could have deleterious effects on cochlear hair cells and eight nerve functions. Therefore, audiological monitoring should be initiated in patients presenting with COVID-19.

Cochlear Implant in cochlear Hypoplasia type 4 with Chiari Malformation- Case Report.

Cochlear hypoplasia type IV is a rare cochlear malformation with hypoplastic middle and apical turns while basal turn develops normally, it often coexist with other genetic mutations. We present a case of 4 year old with chiari malformation type 1 along with bilateral Cochlear hypoplasia type IV who underwent cochlear implantation.

Clinical Profile and Outcomes of Epidemic Dropsy Patients Attending a Tertiary Care Centre in Assam, India.

Background The clinical condition of epidemic dropsy is caused by the consumption of edible oils contaminated with Argemone mexicana oil. Two of the most toxic alkaloids found in argemone oil are sanguinarine and dehydrosanguinarine, which cause capillary dilation, proliferation, and increased permeability. Extreme cardiac decompensation leading to congestive heart failure and glaucoma resulting in blindness are the most serious consequences of epidemic dropsy. Materials and methods All patients attending the medicine department of Tezpur Medical College and Hospital with clinical features of epidemic dropsy were included in the study after obtaining informed consent. All patients, after a complete history, underwent a thorough clinical examination, and findings were recorded using a pre-formed proforma. Along with routine blood examination, patients were also evaluated with echocardiography, ECG, and chest X-ray. Cooking oil samples obtained from patients were investigated for the presence of sanguinarine in a standardized laboratory with the help of the district authority. The statistical analysis was done using MS Excel 2017. Results Out of 38 patients, 36 were male (94.7%), and only two were female (5.2%). Male to female ratio was 18:1. This difference in sex ratio may be due to the fact that only severely ill patients attended our tertiary care hospital. In contrast, moderate and mildly ill patients were treated in local hospitals. The mean age of patients was 28.1 years, and the mean length of hospital stay was eight days. Bilateral pitting type of ankle edema was the most common clinical manifestation, and all 38 patients (100%) exhibited edema. A total of 76% of patients had dermatological manifestations. Sixty-two percent of patients had gastrointestinal manifestations. In cardiovascular manifestation, persistent tachycardia was seen in 52% of patients, pansystolic murmur was best heard in the apical area in 42% of patients, and 21 percent had evidence of a raised jugular venous pressure (JVP). Five percent of patients had pleural effusion. Sixteen percent of patients had ophthalmological manifestations. Eight patients (21%) required ICU care. The in-hospital fatality rate was 10.53% (n=4). Of the expired patients, 100% were male. The most common cause of death was cardiogenic shock (75%), followed by septic shock (25%). Conclusion From our study, it was found that most of the patients were male, with an age group of 25-45 years. The most common clinical manifestation was dependent edema, along with signs of heart failure. Other common manifestations were dermatological and gastrointestinal. The severity and outcome were directly related to the delay in seeking medical consultation and diagnosis.

Management of Traumatic Femur Fractures: A Focus on the Time to Intramedullary Nailing and Clinical Outcomes.

Femur shaft factures (FSF) are common injuries following high-energy mechanisms mainly involving motor vehicle crashes (MVC). We evaluated the timings of nailing management and analyzed the pattern of fracture union and outcome in a level 1 trauma center. This was a retrospective observational study of all the admitted trauma patients who sustained femoral fractures between January 2016 and September 2020. Data were analyzed and compared based on time to Intramedullary Nailing (IMN) (<12 h, 12-24 h and >24 h) and outcomes of FSF (union, delayed union and nonunion). A total of 668 eligible patients were included in the study, of which the majority were males (90.9%) with a mean age of 34.5 ± 15.8, and 54% of the injuries were due to MVCs. The chest (35.8%) was the most commonly associated injured body region, followed by the pelvis (25.9%) and spine (25.4%). Most of femur fractures (93.3%) were unilateral, and 84.4% were closed fractures. The complete union of fractures was observed in 76.8% of cases, whereas only 4.2% and 3.3% cases had delayed union and nonunion, respectively, on the clinical follow-up. Patients in the delayed IMN (>24 h) were severely injured, had bilateral femur fracture (p = 0.001) and had higher rate of external fixation, blood transfusion, pulmonary complications and prolonged hospitalization. Non-union proportion was greater in those who had IMN <24 h, whereas a delayed union was greater in IMN done after 24 h (p = 0.5). Those with a nonunion femur fracture were more likely to have bilateral fracture (p = 0.003), frequently had retrograde nailing (p = 0.01), and high-grade femur fracture (AO type C; p = 0.04). This study showed that femur fracture is not uncommon (8.9%), which is manifested with the variety of clinical characteristics, depending on the mechanism, management and outcome in our center. Bilateral fracture, retrograde nailing and AO classification type C were the significant risk factors of non-union in patients with diaphyseal fractures. The timing of IMN has an impact on the fracture union; however, it is not a statistically significant difference. Therefore, the treating physicians should consider the potential risk factors for a better outcome by careful selection of treatment in sub-groups of patients.

Research on energy acquisition technology based on one-dimensional acoustic black hole effect

In this paper, a piezoelectric energy harvester based on periodic one-dimensional acoustic black holes (ABH) is proposed to improve efficiency. The harvesting performance of the energy harvester with different ABH-structures was numerically simulated through the commercial software, COMSOL Multiphysics. Finally, an experimental platform was set up to test several energy harvester samples. The results show that the energy aggregation effect of the bilateral ABH beam is better than that of the traditional ABH beam. In the optimal impedance matching, the maximum output power of the energy harvester with bilateral ABH type 3 is 112 mW, which is 2.8 times that of the energy harvester with traditional ABH. The simulation and experimental results show that the energy harvesting efficiency of the proposed ABH is much higher than that of the energy harvester with traditional ABH. It is expected to make some contributions to the further development of lightweight wireless sensors, equipment service life, bearing fault diagnosis, and so on.

Predictability of Maxillary Dentoalveolar Expansion Using Clear Aligners in Different Types of Crossbites

The aim of this study was to determine the efficacy and predictability of maxillary dentoalveolar expansion clear aligners in unilateral, bilateral, and single-tooth types of crossbite. This prospective analytical study enrolled adults with dentoalveolar posterior crossbite. Orthoanalyzer™ 1.7 software was used to analyze stl files of digital models before treatment (T1), predicted post-treatment outcome (T2), and observed outcome (T3). Changes in intercanine width, first and second interpremolar widths, and intermolar width were compared using a mixed ANOVA model for repeated measures (α = 0.05). The study included 46 patients aged 20–60 years, 15 with unilateral, 15 bilateral, and 16 single-tooth crossbite. In all crossbite groups, expansion was largest at the second premolar level (unilateral: 2.54 mm; bilateral:, 4.86 mm; single-tooth: 3.41 mm) (ANOVA p &lt; 0.001) and smallest at the canine level. Expansion predictability was 90% at the first premolar level in the single-tooth crossbite group, 86% at the second premolar level in the bilateral crossbite group, and 79% at the second premolar level in the unilateral crossbite group. No significant difference was found between the predicted and observed expansion in any crossbite group. Dentoalveolar expansion using differential anchorage techniques with clear aligners is highly predictable, although the treatment plan should consider overcorrection of the expansion movement to achieve the planned outcome.

Bilateral Facial Nerve Palsy as a Rare Presentation of Systemic Lupus Erythematosus

Abstract Systemic lupus erythematosus (SLE), a disease of the immune system, has a relapsing-remitting course. It is known to affect multiple organ systems of the body, including the nervous system. Cranial neuropathy, particularly facial neuropathy, is an unusual complication of SLE whose pathogenic mechanism is still not understood. Cardiac involvement, like myocarditis and papilledema, is another rare presentation of SLE. A 23-year-old male had bilateral lower motor neuron type of facial palsy which on a thorough investigation was found to be as a manifestation of SLE confirmed by antinuclear antibodies and double-stranded DNA antibody positive test. Electrocardiogram and echocardiography were suggestive of myocarditis. Fundus examination revealed Grade 2 papilledema. The patient was managed with symptomatic treatment along with corticosteroids, to which he responded gradually. Bilateral facial nerve lower motor neuron type palsy is a rare manifestation of SLE which should be diagnosed promptly and can be managed with corticosteroids. The clinician should also keep an eye on infrequent manifestations like myocarditis and papilledema.

Classical and Fixed Point Approach to the Stability Analysis of a Bilateral Symmetric Additive Functional Equation in Fuzzy and Random Normed Spaces

In this article, a new kind of bilateral symmetric additive type functional equation is introduced. One of the interesting characteristics of the equation is the fact that it is ideal for investigating the Ulam–Hyers stabilities in two prominent normed spaces, namely fuzzy and random normed spaces simultaneously. This article analyzes the proposed equation in both spaces. The solution of this equation exhibits the property of symmetry, that is, the left of the object becomes the right of the image, and vice versa. Additionally, the stability results of this functional equation are determined in fuzzy and random normed spaces using direct and fixed point methods.

Effects of distribution of bone cement on clinical efficacy and secondary fracture after percutaneous kyphoplasty for osteoporotic vertebral compression fractures.

To investigate the effect of bilateral bone cement distribution on the clinical efficacy of percutaneous kyphoplasty (PKP) in the treatment of osteoporotic vertebral compression fracture (OVCF). According to strict inclusion and exclusion criteria, 109 cases of OVCF patients treated with bipedicular PKP were included in this study from August 2018 to July 2020. According to the distribution morphology of bilateral bone cement in vertebral body, patients were divided into 3 groups, including Group A (n = 44): bilateral diffuse type; Group B (n = 31): bilateral dense type; Group C (n = 34): mixed type. To assess the clinical and radiographic efficacy of the surgery, the visual analogue scale (VAS) score, Oswestry disability index (ODI) score, anterior vertebral height (AVH), anterior vertebral height ratio (AVHR) and local kyphotic angle (LKA) were recorded at preoperatively, 2 days after surgery and 1 year after surgery. Compared with the preoperative recorded value, the VAS score, ODI score, AVH, AVHR and LKA of the three groups were significantly improved at 2 days after surgery and 1 year after surgery (p < 0.05). At 1 year after surgery, the VAS score of Group A was better than that of groups B and C (p < 0.05), and there were significantly differences in ODI score, AVH, and LKA between Group A and Group B (p < 0.05). Compared with other bone cement distribution patterns, the incidence of recompression in bilateral diffuse bone cement distribution pattern was lower (p < 0.05). In the mid-term follow-up of patients undergoing bipedicular PKP, diffuse and symmetrical distribution of bone cement can obtain better clinical improvement and lower the incidence of secondary compression.

Congenital digital flexural deformity (knuckling): Epidemiology, the association of trace elements and surgical treatment in neonatal bovine calves.

This study aimed to investigate the prevalence and pattern of congenital flexural deformity (knuckling), to identify the association between trace elements and vitamins with the deformity, and to apply different surgical techniques for correcting this congenital malformation in newborn bovine calves. The study was implemented on 17 newborn calves with carpal (knee) and fetlock (foot) knuckling presented to the Veterinary Teaching Hospital of Bangladesh Agricultural University, Mymensingh, from January to December 2020. The serum biochemical alterations and clinical outcomes were assessed on days 0 and 21 following surgery. Two surgical methods: tendon transection and tendon elongation by Z-tenotomy, were performed for surgical restoration. We found that knuckling comprised 12% of the total congenitally malformed calves. The male calves had a higher prevalence (52%, n = 9) and the same in the winter season (65%, n = 11). The majority of the knuckling was bilateral types (88%, n = 15), involving the carpal joint (82%, n = 14) and moderately angulated (59%, n = 10). The serum level of magnesium, iron, vitamin D, and zinc were significantly (p < 0.05) changed from the pre-surgical stage to the stage of non-lameness after surgery. The disorder was surgically treated by tendon transection or tendon elongation procedure and had a good prognosis. The current study concluded that the development of knuckling in calves might be related to a deficiency/excess of specific minerals and vitamins and that it can be effectively corrected by surgical intervention; however, early diagnosis and the use of proper surgical techniques are crucial for improving the prognosis.

Risk factors for cerebral palsy

Background/Aim. Cerebral palsy (CP) etiology is multi-factorial and heterogeneous, manifesting as damage to the developing brain. The associated risk factors can arise in the prenatal, perinatal, or postnatal period. The aim of this study was to determine the risk factors for CP and examine the associations between CP type, gestational age, and perinatal risk factors. Methods. The study sample comprised 206 children with CP. Pertinent data were collected from medical records and included participants? gestational age at birth, medical history, and CP clinical characteristics. Risk factors were divided according to the timing of brain injury into prenatal, perinatal, and neonatal. Results. Hormonally maintained pregnancy (55.3%), twin pregnancy (28.9%), vaginal bleeding after the 20th week of gestation (21.1%), threatened abortion in the first half of pregnancy (13.2%), and maternal infection (10.5%) were identified as the main prenatal risk factors for CP. Prematurity (54.5%) was the leading perinatal risk factor, followed by low birthweight (50.8%), Apgar score &lt; 7 (41.7%), assisted delivery (41.4%), and breech presentation (13.5%). Respiratory distress syndrome (16%), need for treatment in the Neonatal Intensive Care Unit (22.3%), assisted ventilation (18.4%), hypoxic-ischemic encephalopathy (11.2%), and neonatal convulsions (5.8%) were identified as the leading neonatal risk factors for CP. A statistically significant difference was found in the total number of perinatal risk factors in relation to gestational age (p &lt; 0.001) and CP type (p = 0.006). Perinatal risk factors were most prevalent in preterm infants and children affected by the CP of spastic bilateral type. A statistically significant difference was noted in the distribution of CP types de-pending on the gestational age (p &lt; 0.001). In particular, spastic bilateral CP type was most prevalent in the group of preterm-born children. Conclusion. CP is characterized by heterogeneous risk factors and is a result of interaction among multiple risk factors.

Immunohistochemical Algorithm for the Classification of Muscle-Invasive Urinary Bladder Carcinoma with Lymph Node Metastasis: An Institutional Study.

Muscle-invasive urothelial carcinoma represents 20% of newly diagnosed cases of bladder cancer, and most cases show aggressive biological behavior with a poor prognosis. It is necessary to identify biomarkers that can be used as prognostic and predictive factors in daily clinical practice. In our study, we analyzed different antibodies in selected cases of muscle-invasive urinary bladder carcinoma and lymph node metastasis to identify immunohistochemical types and their value as possible prognostic factors. A total of 38 patients were included, 87% men and 13% women, with a mean age of 67.8 years. The most frequent histopathological type was urothelial carcinoma. In the primary lesion, the mixed type was the most common. In unilateral metastasis, the mixed type was the most frequently found. In cases of primary lesions and bilateral metastasis, the luminal and mixed types were observed. The luminal subtype was the most stable in immunohistochemical expression across primary tumors and metastases. The basal type showed a better prognosis in terms of disease-free survival. In conclusion, immunohistochemical studies are useful in assessing primary and metastatic lesions in patients with urothelial carcinoma. Immunohistochemical classification can typify muscle-invasive urothelial carcinoma, and the immunophenotype seems to have prognostic implications.

Comparison of intravitreal injection of ranibizumab versus bevacizumab for treatment of type 1 and aggressive retinopathy of prematurity in rural Egypt. A randomized clinical trial

ObjectiveThe objective of this study is to evaluate the efficacy of intravitreal ranibizumab (IVR) monotherapy compared with intravitreal bevacizumab (IVB) monotherapy for treatment of type 1 and aggressive retinopathy of...

Total Operating Room Time and Total Surgical Procedure Time in Treating Pelvic Ring Fractures with Calcium Phosphate: A Guide for Surgery Scheduling

Introduction: The purpose of this study is to look at total surgery time and to calculate surgical procedure time as well as surgery set up time. Methods: Over an eighteen-month period, 6/2018 -12/2019, we retrospectively reviewed the results of 45 cases of pelvic injuries consisting of fragility fractures. Data consisting of Total OR Time (TOT), Total Surgical Time (TST) and Total Set Up Time (TOT – TST = Total Set Up Time) was recorded at surgery. This information comprises the rationale of this report. Results: Classification of the fracture types were 28 Type Ia, 1 Type Ib, 1 Type IIa, 7 Type IIb, and 8 IVb. Total Operating Room time for Type Ia was one hour. Types IIb which include an ipsilateral sacral alae fracture was again found to take 60 minutes. The Total Set Up Time for Type Ia was 30 minutes. The Total Surgery Time for Type Ia was 30 minutes. The combined Total Operating Room Time for Type IIb fractures, which include the ipsilateral sacral fracture, was 1 hour. Total Surgery Time was less than 1 hour. The 8 bilateral sacral fragility fractures Type IVb was 47 minutes. The times as reported demonstrate procedures representative of the minimally invasive treatment of pubic rami fractures. Discussion: The purpose of this report was to look at the surgical time required to complete a new surgical technique to treat Fragility Fractures of the pelvis. Calcium Phosphate treatment for these fractures provides a delivery system that accommodates comminuted fracture patterns, minimally invasive, and supplies a supportive endothermic material adding stability to the fracture site. Conclusion: Calcium Phosphate treatment is minimally invasive and easily performed. All fracture Types are amendable for this treatment. The times as reported demonstrate procedures representative of the minimally invasive treatment of pubic rami fractures.

A Review of Sensorineural Hearing Loss in Congenital Cytomegalovirus Infection.

The intrauterine transmission of the TORCH group (toxoplasmosis, rubella cytomegalovirus (CMV), herpes simplex, and HIV) produces severe complications in the fetus, leading to major life challenges for the newborns. CMV is considered one of the leading causes of congenital hearing loss in babies born to infected mothers. The majority of the cases are asymptomatic but a certain proportion show symptoms, which may not be present until later. The human cytomegalovirus (HCMV) infection can also be transferred to the baby postnatally through breastfeeding. Mothers facing primary infection from the CMV have a greater tendency to transmit the infection to the fetus, whereas secondary infection due to reactivation of the virus in females who were affected before pregnancy, delivers asymptomatic babies in most cases. Vertical transmission of HCMV,that is via the placenta from infected mother to fetus, is one of the leading causes of congenital sensorineural hearing loss (SNHL) and neurodevelopmental complications in newborns. It accounts for up to 10% of SNHL cases in newborns, of both unilateral and bilateral types. Antiviral therapy is helpful in such cases if administered within the first month of life, and for hearing impairment, cochlear implants have been used to treat children who develop profound hearing loss. The child can present with hearing loss at birth or it may be late in onset and of progressive type. Suspected children should be evaluated regularly for the early detection of hearing loss and to provide the appropriate treatment.