Expotecnología 2022 was an event that took place in the city of Cartagena de Indias, from November 2 to 6, 2022, with the slogan “The future of engineering in the face of technological disruption” This eighteenth version was a meeting that brought together the scientific and academic community in spaces for the dissemination and transfer of knowledge, where innovation was the essence and a fundamental part of the event. Expotecnología was created in the Faculty of Engineering Sciences - FACI, of the Antonio de Arévalo University Foundation - UNITECNAR and in this version it maintained as mission, the development of the interaction between science, technology and society, through establishing of knowledge networks and academic and professional cooperation. The main objective was to address the challenges that emerge from the everyday life of the engineering community, the problems immersed in the development of projects and programs of Higher Education Institutions (IES), organizations and research centers at the national and international level. In the development of the day of presentations in a virtual way, it was possible to promote the dissemination of the research work of professionals, teachers and students from all areas of engineering, framed in four (4) thematic axes, as follows:• New technologies: Big data, Artificial Intelligence, Business Intelligence, Software Engineering, Education and new technologies and Mobile Applications.• Petrochemicals and process control: Materials Science, Instrumentation and Control Systems, Robotics and Automation and Industrial Maintenance.• Electricity, electronics and telecommunications: IoT, Fiber optics, Digital Signal Processing, Wireless Networks, Mobile Communications, Power Systems, Energy Storage, Smart Grids, Renewable Energies, Operation and Distribution, Energy Dispatch, Energy Markets• Construction Summit: Modern Building Systems and Computational Modeling.On this occasion, the event was attended by 512 people, representatives from 25 national and 6 international universities. 32 presentations were made, of which 32 articles were selected for this volume of the IOP Conference Cycle: Materials Science and Engineering and 13 articles for the book Engineering, Innovation and the fourth industrial revolution., After a process of Peer Review. The plenary conferences were in charge of 2 national and 8 international speakers .List of Invited speakers, Organizing Committee, Special thanks are available in this pdf.