Reversible and nonvolatile electric-field control of the physical properties of topological insulators is essential for fundamental research and development of practical electronic devices. Here, we report the integration of topological insulator films with ferroelectric Pb(Mg1/3Nb2/3)O3-PbTiO3 (PMN-PT) single crystals in the form of ferroelectric field-effect devices that allow us to tune the electronic properties of topological insulator films in a reversible and nonvolatile manner. Specifically, gating of Cr-doped Bi2Se3 films with the PMN-PT layer is shown to provide a means to reversibly tune and modulate the carrier density and carrier type, as well as its other properties, such as the conductance, magnetoconductance, Fermi level, phase coherence length, and screening factor of electron–electron interaction by polarization switching at room temperature. These findings provide a simple and direct approach for probing the quantum transport properties of topological insulator films through ferroelectric gating by using PMN-PT. The combination of topological insulators with both ferroelectrically and piezoelectrically active PMN-PT thus offers a promising step toward exploring topological insulator/ferroelectric(piezoelectric) hybrid devices that could utilize not only the ferroelectric field-effect of topological insulator/PMN-PT structures but also the unique properties of respective materials.