Introduction: Oral submucous brosis is a persistent, insidious mucosal condition that is primarily brought on by areca nut use. It can also be brought on by excessive use of peppers, dietary deciencies, autoimmune, genetics, and environmental factors. The aim of the Aim Of The Study: study was to evaluate the effectiveness of vasodilator isoxsuprine as an adjuvant in the oral submucous brosis management. Study Design: Twenty patients with OSMF were recruited and randomly two groups were divided. Group A: Patients got treated with Isoxsuprine hydrochloride 10 mg thrice daily and antioxidants (Lycopene) twice daily for 3 months. Whereas, in the Group B, antioxidants two times a day for 3 months were given. Both were instructed for mouth opening exercises. All individuals, mouth opening, burning sensation were recorded and reassessment was done at every 15 days during the treatment and after 3 months follow-up and followed by statistical analysis. Visual Analogue Scale Results: (VAS) score for severity of burning sensation was observed in both the groups A &B was statistically signicant whereas interincisal opening was higher in group A patients. Isoxsuprine Hydrochloride can be suggested as an adjunctive t Conclusion: herapy in oral submucous brosis management.