AbstractWe prove results on complex interpolation of vector‐valued Sobolev spaces over the half‐line with Dirichlet boundary condition. Motivated by applications in evolution equations, the results are presented for Banach space‐valued Sobolev spaces with a power weight. The proof is based on recent results on pointwise multipliers in Bessel potential spaces, for which we present a new and simpler proof as well. We apply the results to characterize the fractional domain spaces of the first derivative operator on the half line.