Juvenile ossifying fibromas (JOFs) are benign fibro-osseous neoplasms observed in young individuals that, in cases of gneissic bones, are preferentially located in the maxilla and have histopathologic features very similar to other benign fibro-osseous lesions (BFOL). A 17-year-old male adolescent presented asymptomatic volume increase located in the right maxillary ridge region with a 6-month history of radiographic examination, showing the presence of mixed lesion with clear borders and a radiopaque center, an aspect of ground glass, and displacement of teeth. Histologic sections stained with hematoxylin and eosin (HE) revealed fragments a JOF with presence of cellular fibrous connective tissue containing spherical ossicles with basophilic centers and peripheral eosinophilic margins with JOF diagnosis. In this case, the outstanding histopathologic characteristics of the JOF are presented to differentiate it from the BFOL.