Updated systematic review: ossifying fibromas of the nose and paranasal sinuses

Abstract

<p class="p1">Ossifying fibroma is one of the benign fibro-osseous lesions (BFOL), which is a relatively rare group of diseases of the bone with diverse pathologies and involving different parts of the body and mostly craniofacial bones. BFOLs share a common histopathologic feature of replacing the normal bony tissue structure with a distorted fibrous and mal-arranged bony structure. Although, ossifying fibroma is pathologically benign, but it’s presentation can vary from an incidental radiologic finding to a devastating facial mass with cosmetic and functional disabilities. And the management is according to the site involved and the symptomatology.<strong> </strong>The purpose of this systematic review is to collect the available recent data regarding ossifying fibromas involving nose and paranasal sinuses, to have a better understanding of the disease, and its management. This review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement and PRISMA checklist. The U.S. National Library of Medicine (Pubmed) database was searched. Abstracts were screened by two authors and the ones that met the inclusion and exclusion criteria were included. Additional articles were retrieved from the citations in the previously found articles. A total of 156 distinct cases were found. Demographic data, clinical presentation, radiological and pathological findings and the management approaches were reviewed.<strong> </strong>Review of the recent data highlighted new diagnostic, imaging and management strategies that should be considers in the approach to patients with ossifying fibroma.</p>