Benefits For People Research Articles

Comparative Cardiovascular Effectiveness of Empagliflozin Versus Dapagliflozin in Adults With Treated Type 2 Diabetes: A Target Trial Emulation.

Empagliflozin and dapagliflozin have proven cardiovascular benefits in people with type 2 diabetes at high cardiovascular risk, but their comparative effectiveness is unknown. This study used nationwide, population-based Danish health registries to emulate a hypothetical target trial comparing empagliflozin versus dapagliflozin initiation, in addition to standard care, among people with treated type 2 diabetes from 2014 through 2020. The outcome was a composite of myocardial infarction, ischemic stroke, heart failure (HF), or cardiovascular death (major adverse cardiovascular event). Participants were followed until an outcome, emigration, or death occurred; 6 years after initiation; or December 31, 2021, whichever occurred first. Logistic regression was used to compute inverse probability of treatment and censoring weights, controlling for 57 potential confounders. In intention-to-treat analyses, 6-year adjusted risks, risk differences, and risk ratios considering noncardiovascular death competing risks were estimated. Analyses were stratified by coexisting atherosclerotic cardiovascular disease and HF. A per-protocol design was performed as a secondary analysis. There were 36 670 eligible empagliflozin and 20 606 eligible dapagliflozin initiators. In the intention-to-treat analysis, the adjusted 6-year absolute risk of major adverse cardiovascular event was not different between empagliflozin and dapagliflozin initiators (10.0% versus 10.0%; risk difference, 0.0% [95% CI, -0.9% to 1.0%]; risk ratio, 1.00 [95% CI, 0.91 to 1.11]). The findings were consistent in people with atherosclerotic cardiovascular disease (risk difference, -2.3% [95% CI, -8.2% to 3.5%]; risk ratio, 0.92 [95% CI, 0.74 to 1.14]) and without atherosclerotic cardiovascular disease (risk difference, 0.3% [95% CI, -0.6% to 1.2%]; risk ratio, 1.04 [95% CI, 0.93 to 1.16]) and in people with HF (risk difference, 1.1% [95% CI, -6.5% to 8.6%]; risk ratio, 1.04 [95% CI, 0.79 to 1.37]) and without HF (risk difference, -0.1% [95% CI, -1.0% to 0.8%]; risk ratio, 0.99 [95% CI, 0.90 to 1.09]). The 6-year risks of major adverse cardiovascular event were also not different in the per-protocol analysis (9.1% versus 8.8%; risk difference, 0.2% [95% CI, -2.1% to 2.5%]; risk ratio, 1.03 [95% CI, 0.80 to 1.32]). Empagliflozin and dapagliflozin initiators had no differences in 6-year cardiovascular outcomes in adults with treated type 2 diabetes with or without coexisting atherosclerotic cardiovascular disease or HF.

Everyday Uses of Music Listening and Music Technologies by Caregivers and People With Dementia: Survey and Focus Group Study.

Music has long been identified as a nonpharmacological tool that can provide benefits for people with dementia, and there is considerable interest in designing technologies to support the use of music in dementia care. However, to ensure that music technologies are appropriately designed for supporting caregivers and people living with dementia, there remains a need to better understand how music is currently used in everyday dementia care at home. This study aims to understand how people living with dementia and their caregivers use music and music technologies in everyday caring, as well as the challenges they experience using music and technology. This study used a mixed methods design. First, a survey was administered to 13 people living with dementia and 64 caregivers to understand their use of music and technology. Subsequently, 18 survey respondents (family caregivers: n=12, 67%; people living with dementia: n=6, 33%) participated in focus groups regarding their experiences of using music and technology in care. Interview transcripts were analyzed using reflexive thematic analysis. Most of the survey respondents (people living with dementia: 9/13, 69%; family caregivers: 47/63, 75%) reported using music often or very often in their daily lives. Participants reported a range of technologies used for listening to music, such as CDs, radio, and streaming services. Focus groups highlighted the benefits and challenges of using music and music technologies in everyday care. Participants identified using music and music technologies to regulate mood, provide joy, facilitate social interaction and connection, encourage reminiscence, provide continuity of music use before and after the dementia diagnosis, and make caregiving easier. The challenges of using music technology in everyday caring included difficulties with staying up to date with evolving technology and low self-efficacy with technology for people living with dementia. This study shows that people with a dementia diagnosis and their caregivers already use music and music technologies to support their everyday care needs. The results suggest opportunities to design technologies that enable easier access to music and to support people living with dementia with recreational and therapeutic music listening as well as music-based activities.

Research on the Effect of Successful Business People on the Society

It is known that successful business people play a crucial role in wealth creation and expenditure. This paper mainly discussed whether successful business people benefit others when making their money, when spending it, both, or neither? This paper seeks to shed light on these questions, exploring the complex relationship between wealth accumulation and societal benefits. This paper examines the extent to which wealthy individuals benefit others during the process of wealth creation and expenditure, considering both top-down and bottom-up economic perspectives. By utilizing the true situation using Top-Down and Bottom-Up perspective, this paper draws the conclusion that: On the one hand, when the successful business people have social responsibility, they use the method of making money to provide people with employment and re-employment, they have great love and universal love, and they shoulder the responsibility of the savior. On the other hand, when successful businessmen have more and more money, it will lead to the wealth of the society in the hands of a few people, affecting the reasonable development of politics and economy.

Mirabegron 50 mg once daily, long-term treatment maximizes benefit in middle-aged and older people with overactive bladder syndrome: a systematic review and meta-analysis of nine phase II/III, randomized, double-blind, parallel-design, placebo-controlled, multicenter, and multinational trials.

The prevalence and severity of overactive bladder increase with age, and mirabegron is an approved treatment for this condition. This meta-analysis systematically evaluated the efficacy and safety of mirabegron compared with placebo for overactive bladder treatment. We searched PubMed and the Cochrane Library (30 October 2023) for relevant articles (source: MEDLINE, EMBASE, ClinicalTrials.gov, ICTRP, CINAHL). We included randomized controlled trials involving adults with overactive bladder syndrome that compared mirabegron with placebo treatment. Data were analyzed according to the Cochrane Handbook for Systematic Reviews of Interventions [Review Manager (computer program) Version 5.4]. Nine parallel-group trials (10 articles) were included. The evaluation included a total of 8,527 adults, including 6,445 women and 2,082 men, of whom 5,726 were White, 2,462 were Asian, and 161 were Black. The mean age of the participants ranged from 53.4 to 60.3 years. This evaluation involved three specifications of mirabegron: 25 mg, 50 mg, and 100 mg. In all trials, patients were enrolled in a 12-week double-blind treatment period, and the dose was once daily. The review of trials found that on average, people taking mirabegron had about 13 ml more volume voided per micturition, five fewer micturitions, and four fewer incontinence episodes every week, with moderate improvements in quality of life. About one in five people taking the drug reported TRAEs. Mirabegron treatment is well tolerated, with the risk of adverse events similar to that of a placebo. For best results, a dose of 50 mg once daily is recommended for long-term use. It is unclear whether any benefits are sustained after treatment discontinuation. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/, PROSPERO (CRD42023430737).

A critical hit: Dungeons and Dragons as a buff for autistic people.

Tabletop role-playing games (TTRPGs) are popular hobbies that may offer specific social benefits for autistic people. This study investigated the ability of TTRPGs to provide a safe space where autistic adults could develop relationships with other autistic adults while engaging in character and world-building. A group of eight autistic adults were split into two groups and taken through a short-form online Dungeons and Dragons campaign over 6 weeks run by one of the researchers. The researcher then led a series of individual semi-structured interviews discussing how participants felt interacting in and out of the TTRPG. Several key themes were identified as important aspects of why autistic people could benefit from such an environment. Analysis showed that while real-life interactions could be challenging, in TTRPG play, they felt they experienced significantly fewer struggles. Results suggested that TTRPGs can provide a safe space environment where autistic adults can engage in productive social interactions with like-minded individuals. It also may allow autistic participants to experience 'bleed' or the ability to take on a new character that changes the way they feel about themselves outside of the game. Future directions for this work are discussed.

Functional neurological disorder in Europe: regional differences in education and health policy.

Functional neurological disorder (FND) is a common cause of neurological disability. Despite recent advances in pathophysiological understanding and treatments, application of this knowledge to clinical practice is variable and limited. Our aim was to provide an expert overview of the state of affairs of FND practice across Europe, focusing on education and training, access to specialized care, reimbursement and disability policies, and academic and patient-led representation of people with FND. We conducted a survey across Europe, featuring one expert per country. We asked experts to compare training and services for people with FND to those provided to people with multiple sclerosis (MS). Responses from 25 countries revealed that only five included FND as a mandatory part of neurological training, while teaching about MS was uniformly included. FND was part of final neurology examinations in 3/17 countries, unlike MS that was included in all 17. Seventeen countries reported neurologists with an interest in FND but the estimated mean ratio of FND-interested neurologists to MS neurologists was 1:20. FND coding varied, with psychiatric coding for FND impacting treatment access and disability benefits in the majority of countries. Twenty countries reported services refusing to see FND patients. Eight countries reported an FND special interest group or network; 11 reported patient-led organizations. FND is largely a marginal topic within European neurology training and there is limited access to specialized care and disability benefits for people with FND across Europe. We discuss how this issue can be addressed at an academic, healthcare and patient organization level.

Social Impact Assessment Project on Cholangiocarcinoma Screening and Care Program

The research aims to assess users utility and cost-effectiveness based on the results of rapid antigen test kits for urine and abdominal ultrasound methods. This study uses qualitative methods to analyze liver fluke screening among individuals aged 40 and above in four provinces. Purposive sampling was used, with 373 participants and 379 participants, respectively. Utility measurement tools included a direct Visual Analog Scale (VAS) and indirect EuroQoL (5Q-5D-5L), and willingness to pay value was measured using bidding. The result shows that the sample group has an average VAS score of 76.90, with slight pain or discomfort reported in the five health dimensions. The utility value reflecting daily quality of life is 0.89. The average willingness to pay per use for rapid test kits and abdominal ultrasounds is 187 baht and 796 baht, respectively. Reasons for not paying higher include income factors, high prices, and personal limitations. However, participants believe public hospitals could support examination costs and provide access to benefits. The project benefits people economically, socially, and culturally, and if the Ministry of Public Health and related agencies can effectively use it, it will maximize benefits.

Optimizing kidney and cardiovascular protection in an era of multiple effective treatments.

After decades of relying on the control of hypertension and treatment with renin angiotensin system inhibitors as the only evidence-based interventions to slow the progression of chronic kidney disease (CKD), we have entered an era when multiple effective treatment options are available. This review considers the mechanisms and benefits of these novel treatments as well as the challenges associated with achieving optimal combination therapy. Over the past 5 years, large clinical trials have provided robust evidence that, when added to renin angiotensin system inhibitors, treatment with sodium glucose cotransporter 2 inhibitors reduces the rate of CKD progression and the risk of cardiovascular events in people with CKD with or without diabetes and with or without albuminuria; nonsteroidal mineralocorticoid antagonists and glucagon-like peptide-1 receptor agonists afford similar benefits in people with type 2 diabetes and CKD. The mechanisms of actions of these novel therapies suggest that combination therapy will produce additive benefits, though specific evidence is sparse. Further trials are warranted to investigate the benefits of combination therapy with novel treatments in people with CKD. Clinical implementation of optimal combination therapy will require reorganization of services to ensure that patients receive adequate education, support and monitoring.

A Novel Aircraft Trajectory Generation Method Embedded with Data Mining

Data mining has achieved great success in air traffic management as a technology for learning knowledge from historical data that benefits people. However, data mining can rarely be embedded into the trajectory optimization process since regular optimization algorithms cannot utilize the functional and implicit knowledge extracted from historical data in a general paradigm. To tackle this issue, this research proposes a novel data mining-based trajectory generation method that is compatible with existing optimization algorithms. Firstly, the proposed method generates trajectories by combining various maneuvers learned from operation data instead of reconstructing trajectories with generative models. In such a manner, data mining-based trajectory optimization can be achieved by solving a combinatorial optimization problem. Secondly, the proposed method introduces a majorization–minimization-based adversarial training paradigm to train the generation model with more general loss functions, including non-differentiable flight performance constraints. A case study on Guangzhou Baiyun International Airport was conducted to validate the proposed method. The results illustrate that the trajectory generation model can generate trajectories with high fidelity, diversity, and flyability.

Landscape structure influences the spatial distribution of urban bird attractiveness

ContextLandscape change affects biological diversity and the distribution of species traits related to spiritual, educational, and recreational benefits people derive from nature. These traits are associated with color, song and behavioral characteristics that influence people's perceptions of how attractive an assemblage is. However, the environmental variables that affect the spatial distribution of traits related to the attractiveness of biological diversity remain unexplored.ObjectivesWe tested how landscape structure influences patterns of perceived bird attractiveness (trait diversity associated with colorfulness, behavioral and song categories) across an urbanization gradient.MethodsWe used data from standardized surveys of birds and landscapes within 42 landscape units of 1km2 across the city of Brisbane in eastern Australia. We used structural equation modeling to test effects of landscape composition (built infrastructure, percentage of tree cover) and landscape configuration (fragmentation of tree cover) on mean bird community attractiveness. Relationships between individual traits and landscape structure were analyzed using multinomial logistic regression models.ResultsOur analysis across 82 bird species shows that the relative amount of built infrastructure in a landscape interacts with fragmentation to reduce the overall attractiveness of the landscape’s bird assemblage. However, built areas can exhibit high overall bird attractiveness where there is (1) reduced fragmentation and (2) increased diversity of vegetation structure that provides key habitats for many colorful species with a high diversity of calls. Relationships between bird attractiveness and landscape structure change when they are analyzed at the guild level (insectivores vs frugivores/nectarivores). In addition, body size moderates the effects of landscape structure on song complexity, personality, and color.ConclusionsSmall bodied, colorful and melodious species are negatively affected by built infrastructure and fragmentation. By learning how habitat loss and fragmentation affect the distribution of species-rich, attractive bird assemblages, our findings can inform how urban landscapes might be structured to increase people’s connection with nature.

Theory of the nation in the scientific concept of Lev Rebet

The article analyzes the life and work of L. Rebet, his general theoretical views on the formation and development of the nation. Considerable attention is paid to the characterization of L. Rebet’s fundamental scientific works on the theory and history of the Ukrainian nation, in particular: “The Formation of the Ukrainian Nation”; “Theory of the Nation”; “The Origin of Ukrainians, Russians, Belarusians in the Light of Modern Soviet Theories”; “The Light and Shadows of the OUN”, etc. It is shown that in his scientific concept of the formation and development of the nation, Lev Rebet examined in detail the causes of the decline, economic and cultural isolation of the Ukrainian community during the Golden Horde, analyzed the causes of the territorial fragmentation of the Ukrainian principalities and determined the importance of the Galicia-Volhynia State for the continuation of the state life of the Ukrainian people. Using historical examples, L. Rebet identified the negative impacts on the Ukrainian population under the Lithuanian and Polish occupation of Ukrainian lands. L. Rebet rightly noted that during the revival of the Ukrainian people, religion and the Orthodox faith played an important role, opposing Catholicism and polonization and becoming the bearers of Ukrainian tradition and the formation of national consciousness. It was the Ukrainian bourgeoisie, part of the petty gentry, and artisans who proved to be the bearers of culture and state traditions. However, it was only the independent Ukrainian military Cossack stratum that became the military and organizational force that quickly acquired the features of a national state, and in the era of Bohdan Khmelnytsky’s hetmanship, thanks to the military and political success of the Cossacks, one of the most powerful Ukrainian states of that time emerged, which played a significant nation-building role and for several years “crystallized the Ukrainian community, approaching a higher type - the nation”, in which the Cossacks were the main political force. The article reveals that L. Rebet in his works considered nationalism as an ideology that should be based on feelings of national dignity, self-respect and national consciousness. L. Rebet convincingly argued in his writings that the Ukrainian people have the right to political self-determination and the creation of their own state. L. Rebet believed that in order to build one’s own state, first of all, it is necessary to raise the national consciousness and culture of the people. According to L. Rebbetzin, this requires the Ukrainian people to return to their national roots, to their own history and culture, in order to preserve and establish their national identity. In his scientific concept, Lev Rebet emphasized the importance of preserving Ukrainian culture and language, and of preserving the national identity of Ukrainians. Nationalism should be democratic and social. He sought to create a national liberation organization that would unite different segments of the population and work for the benefit of the entire Ukrainian people. L. Rebet favored the creation of national statehood, but believed that the source of power in the state should be the people, not the political elite. Rebet’s views on the importance of moral virtues and cultural values, such as freedom, justice, honesty, diligence, creativity, traditions, religion, and language, are particularly relevant. Rebet believed that these values are important for Ukrainian and other nations.

Impact of maintenance regimes on species richness in newly established perennial wildflower meadows

Perennial wildflower meadows contribute to the enhancement of the quality of urban green spaces, of-fering benefits for both people and wildlife. Significant impact is attributed to management in fostering species-diverse plant communities. However, there are not enough studies exploring the influence of early maintenance regimes on plant diversity. A three-year experiment was conducted to investigate the impact of maintenance regimes on newly established perennial wildflower meadows and the influence of sowing mix on species richness. Three types of perennial wildflower seed mixes were sown on arable land and managed differently during the initial year. Results indicate statistical significance for each main effect, including maintenance type and sowing mix, with no significant interaction between these factors. Mowing during the early growth stage is shown to increase species richness, while no significant difference is observed between weeded and unmanaged plots. The dry meadow sowing mix demonstrates the highest diversity index (Shannon-Weaver, 1963). Maintenance regimes exhibit a significant influence on species richness independently of the sowing mix used. Furthermore, mowing during the early growth stage is found to enhance species diversity in the long term. These findings provide beneficial insights for the more efficient management and establishment of species-rich wildflower perennial meadows in both urban and suburban environments, particularly in areas with a significant soil weed seed bank.

Data sharing in cancer research: A qualitative study exploring community members' preferences.

Advancements in cancer treatment and survivorship rely on participation in research and access to health records. This study explored preferences for data access and sharing in 14 workshops with 42 community members, most of whom were a cancer survivor or carer. Various scenarios for data access and sharing were presented and discussed, with participants' preferences summarized using descriptive statistics. Reasons underlying these preferences were identified through a thematic analysis of workshop transcripts. Most participants indicated a willingness for researchers to use their self-report data and current health records for a specific research project (86%). Many were also willing for their self-report data and current (62%) or all future (44%) health records to be shared with other researchers for use in other studies if made aware of this. Willingness to consent to data access and sharing data in cancer research was influenced by: (i) the potential for data sharing to advance medical discoveries and benefit people impacted by cancer in the future, (ii) transparency around researchers' credibility and their intentions for data sharing, (iii) level of ownership and control over data sharing, and (iv) protocols for privacy and confidentiality in data sharing. Based on these themes, we present practical strategies for optimizing data access and sharing in cancer research.

The Effects of Islamic Economy and Islamic Finance on Social Life

Living together comes with both advantages and disadvantages. On the positive side, people benefit from each other by fulfilling mutual needs, such as buying goods and services that they cannot produce themselves. However, living together can also lead to conflicts, with individuals sometimes infringing on each other's rights. Islam brought significant changes to ensure justice in social life, introducing rules and innovations in economy and finance. When these Islamic principles are followed, justice and social welfare improve. This study will explore Islamic economy and finance and their effects on social life.

Finding my tribe: a qualitative interview study of how people living with metastatic breast cancer perceive support groups.

This study explored the value of metastatic breast cancer (MBC) support groups, and factors that affect attendance, from the perspective of people with MBC. Semi-structured interviews were conducted with 28 women with MBC (support group attendees n = 16; non-attendees n = 12) between January 2022 and July 2023. Data were analysed using an inductive approach to thematic analysis. Three themes were generated: the value of sharing experiential knowledge, spaces for open and honest conversations, and opportunities to find connection and community. These factors were the main reasons that some participants valued, and chose to attend, an MBC support group. Stage-specificity and professional facilitation were identified as important aspects of group structure. Key reasons for non-attendance were concerns about misinformation, confronting the death of group members, and satisfaction with existing support networks. MBC support groups are beneficial for some people with MBC, providing opportunities to connect with others with the same diagnosis. For others, different forms of peer support such as online forums or one-on-one support may be preferred. We argue that ensuring those with MBC have equal access to the peer support they need will be essential in supporting people to live as well as possible with MBC. MBC support groups, if appropriately led, can provide emotional and informational benefits for people with MBC. This research may also have relevance to other metastatic cancers where novel therapies are extending survival, resulting in an emerging cancer population with distinct supportive and survivorship needs.

Designing Food Hubs for Territories of Proximity: Assessing the Spatial, Ecological, and Cultural Potentials of Places through Multi-Criteria Decision Support Systems

Logistics, distribution models, and landscapes of food production strongly influence the space of our cities and territories. In addition to the network of large-scale retail distribution that is diffused in urban and non-urban areas, with this contribution, we study the presence of new forms of the local and sustainable distribution of food (such as Alternative Food Networks, and community-supported agriculture). Studying and understanding how these distribution models can support and be integrated within a landscape planning and design approach is explored through the Analytic Hierarchy Process (AHP), a multi-criteria decision analysis method. Through the specific focus of a Food Hub localization, the aim is to demonstrate how distribution models can not only support but also integrate into landscape planning and design. The fundamental objectives for structuring and locating a Food Hub can be organized under three strategic objectives: pursuing the benefit of people, the planet, and profit. The choice of one distribution method over others, or what is the best location and condition for distribution centers, is the question we have tested with the collaboration of “L’Ortazzo” Association. The case study is a solidarity purchasing group located in the upper Valsugana valley area (Trentino Region, Italy), a supra-municipality reality involving about a hundred families that, currently, do not have a physical distribution center.

Mentoring-values and profiles in primary and preschool education

Because few schools consistently provide a sustainable preparation for the school of the future and for life, it takes a person to make us see, learn and apply what we cannot see, learn, apply on our own. More precisely, an experienced person, willing to share real personal creative experience, for the benefit of other people, of the institution in which he integrates through a relationship based on management, on respect and trust, on superior knowledge, on existing legislation, on intuition and self-created opportunities. This person is the leader, the coach and even the mentor. The field is naturally called leadership, and on a managerial and didactic professional level it is called mentoring. A quality mentoring activity has an important role in anticipating and reducing the difficulties that could intervene in the teaching career of future teachers. I will reflect on the training and career development of teachers from the perspective of the importance of mentoring, in order to ensure a quality education for children through adequate training of teachers. In order to achieve performance, it is necessary to combine theory and practice harmoniously and to acquire the ability to use the knowledge gained in new learning contexts. The study will identify solutions for improving the quality of education by introducing the role of mentoring in the development of the teaching career. After carrying out the research, I will know the degree of satisfaction of the actors involved, with special reference to their activity in kindergarten and school and to the real and harmonious progress of preschoolers and students.

Unequal geographies of gender-affirming care: A comparative typology of trans-specific healthcare systems across Europe

RationaleGender-affirming healthcare can carry significant benefits for trans people. However, there are substantial geographical inequalities in the provision of and access to trans-specific healthcare across Europe. Comparative healthcare systems research has typically focused on universal services, neglecting provision which serves specific groups within populations (e.g., trans people). ObjectiveThis study aimed to develop a comparative typology of trans-specific healthcare systems across 28 European countries (the EU 27 plus the UK), and to examine country-level correlates which may influence or be influenced by these systems. MethodsUsing hierarchical and k-means cluster analysis, countries were classified into four types based on measures of trans-specific healthcare provision, regulation and access. Possible country-level correlates (including socio-political climate, medical outcomes, and the general healthcare system) were investigated. Results and discussionThe cluster analysis identified four clusters of trans-specific healthcare systems in Europe, characterized as: 1) Centralized conservative (highly centralized, extensive range of treatments, few trans-specific government policies); 2) Centralized reformist (highly centralized, extensive range of treatments, multiple trans-specific government policies); 3) Decentralized marketized (highly decentralized, moderate range of treatments, few trans-specific government policies); 4) Underdeveloped (highly decentralized, limited range of treatments, few or no trans-specific government policies). We found statistically significant differences between the clusters in rates of: public support for trans people; gender identity concealment; treatment access; overall health expenditure; gender inequality. ConclusionsThe study develops a novel typology of trans-specific healthcare systems in Europe. It also identifies a range of potential drivers and outcomes of geographical divergences and inequalities in trans-specific healthcare provision. Building on this typology, future comparative research should aim to link the structure of healthcare systems to outcomes for trans people. Comparative healthcare systems research must account for the distinctive forms taken by services and systems that provide healthcare to specific groups within populations.

The interactive effects of different exercises and hawthorn consumption on the pain threshold of TMT-induced Alzheimer male rats

Exercise increases the pain threshold in healthy people. However, the pain threshold modulation effect of exercise and hawthorn is unclear because of its potential benefits in people with persistent pain, including those with Alzheimer's disease. Accordingly, after the induction of Alzheimer's disease by trimethyl chloride, male rats with Alzheimer's disease were subjected to a 12-week training regimen consisting of resistance training, swimming endurance exercises, and combined exercises. In addition, hawthorn extract was orally administered to the rats. Then, their pain threshold was evaluated using three Tail-flick, Hot-plate, and Formalin tests. Our results showed that Alzheimer's decreased the pain threshold in all three behavioral tests. Combined exercise with hawthorn consumption had the most statistically significant effect on Alzheimer's male rats' pain threshold in all three experiments. A combination of swimming endurance and resistance exercises with hawthorn consumption may modulate hyperalgesia in Alzheimer's rats. Future studies need to determine the effects of these factors on the treatment and/or management of painful conditions.Graphical

The Role and Benefits of People's Requirements (MPRS) in The Indonesian State System after The 1945 Amendment: Optimization and Challenges

The study seeks to examine the role and jurisdiction of the People's Assembly of Permusyavaratan (MPR) within the Indonesian statehood system after the modification of UUD 1945. It also intends to identify the efforts made to optimize its functioning and the problems encountered. Normative legal research methods are employed to specifically analyze primary, secondary, and tertiary legal material. The primary legal materials consist of the 1945 Basic Act and its subsequent changes, along with the relevant statutes that regulate the MPR. Secondary legal resources encompass pertinent literature, periodicals, and scientific publications. The research findings indicate that the modifications made to the 1945 UUD have limited the jurisdiction of the MPR, which currently possesses only one primary authority while the others are considered secondary. Constitutional Supremacy establishes the Constitution as the primary framework for governing the state, with the MPR being seen as an autonomous institution alongside the DPR and DPD. While the powers of the MP are restricted, responsibilities like the Socialization of the Four Pillars continue to be essential in maintaining the fundamental foundations of the state. The enhancement of the MPR's authority relies significantly on the agreement among parliament members as stated in the MD3 Act. The primary obstacle it faces is to ensure the MPR remains relevant and effective in a constantly changing statehood environment. The paper suggests implementing strategic initiatives to enhance the role of MPR in the Indonesian statehood system by implementing policy reforms and improving institutional capability.